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  1. Healthcare-associated infections (HAI) lead to poor patient outcomes, including morbidity, mortality, length of hospital stay (LOS) and costs. However, limited data exists on the impact of HAI on LOS, cost at ...

    Authors: Changpeng Liu, Chunhua Song, Yijie Chen, Xi Li, Yamei Qiao, Xiaowen Zhang, Dongjian Yang and Hongshan Huang
    Citation: BMC Cancer 2025 25:595
    Content type: Research Published on:

  2. Metastatic spinal tumors pose a significant challenge regarding intraoperative blood loss. Identifying risk factors for intraoperative blood loss is crucial for appropriate surgical planning and early interven...

    Authors: Xuedong Shi, Yunpeng Cui, Bailin Wang, Yuanxing Pan, Bing Wang, Yong Qin and Mingxing Lei
    Citation: BMC Cancer 2025 25:594
    Content type: Research Published on:

  3. Human oral tongue squamous cell carcinoma (OTSCC) is a prevalent form of head and neck squamous cell carcinoma (HNSCC), often presenting at an advanced stage with a grim prognosis. Traditional therapeutic appr...

    Authors: Shiyuan Liu, Tian Guan, Futian Yang, Honglei Zhang, Yao Yao, Jiman Huang, Pengfei Zhao, Wei Huang, Tailiang Wu, Hui Lin, Ting Fu, Shaoyu Chen, Pengzhan Dai, Zhechun Ding, Dongmei Chen, Wei Li…
    Citation: BMC Cancer 2025 25:593
    Content type: Research Published on:

  5. Metabolism and stemness-related genes (msRGs) are critical in the development and progression of lung adenocarcinoma (LUAD). Nevertheless, reliable prognostic risk signatures derived from msRGs have yet to be ...

    Authors: Wanrong Zheng, Chuchu Zhou, Zixin Xue, Ling Qiao, Jianjun Wang and Feng Lu
    Citation: BMC Cancer 2025 25:591
    Content type: Research Published on:

  6. Although the recommended minimal lymph node yield (LNY) in colon cancer is 12, this standard remains controversial in elderly patients with right-sided colon cancer (RSCC) due to insufficient evidence. This st...

    Authors: Tianyi Liu, Shuai Jiao, Shan Gao and Yan Shi
    Citation: BMC Cancer 2025 25:590
    Content type: Research Published on:

  7. This study aimed to assess the predictive value of radiomic analysis derived from primary lesions and ipsilateral axillary suspicious lymph nodes (SLN) on dynamic contrast-enhanced MRI (DCE-MRI) for evaluating...

    Authors: Yiyao Sun, Qingxuan Liao, Ying Fan, Chunxiao Cui, Yan Wang, Chunna Yang, Yang Hou and Dan Zhao
    Citation: BMC Cancer 2025 25:589
    Content type: Research Published on:

  8. Radiotherapy (RT) can trigger immunogenic cell death which may be exploited to improve the effectiveness of immunotherapy. However, recent results from clinical trials testing RT/immunotherapy combinations in ...

    Authors: M. M. Hasibuzzaman, Rui He, Ishrat Nourin Khan, Aliasger K. Salem and Andrean L. Simons
    Citation: BMC Cancer 2025 25:588
    Content type: Research Published on:

  9. Liquid biopsy, which facilitates minimally invasive analysis of body fluid samples, has considerable potential as a diagnostic and prognostic tool in various cancers. Analysis of circulating tumour cells, circ...

    Authors: Naoki Furukawa, Nobuhiko Hasegawa, Daisuke Kubota, Yasuhiro Nakamura, Hirokazu Tanaka, Shintaro Iwata, Akira Kawai, Tsuyoshi Saito, Tatsuya Takagi, Shinji Kohsaka and Muneaki Ishijima
    Citation: BMC Cancer 2025 25:587
    Content type: Research Published on:

  10. Increasing trends of anal cancer among men who have sex with men (MSM) highlight the importance of anal cancer screening. However, the screening rate of anal cancer among MSM remains relatively low. This syste...

    Authors: IatTou Sam, Wen Dang, NgaTeng Iu, ZiYue Luo, Yu-Tao Xiang and Robert David Smith
    Citation: BMC Cancer 2025 25:586
    Content type: Systematic Review Published on:

  12. We performed this meta-analysis to investigate the potential relationship between the polymorphism of the rs5743836 gene of toll-like receptors 9 (TLR9) and the risk of lymphoma.

    Authors: Minchao Yan, Qin Jin, Yan Zhou, Shuping Mo, Lun Tang, Gang Zhang, Qinyan Fu and Hui Zeng
    Citation: BMC Cancer 2025 25:584
    Content type: Systematic Review Published on:

  14. MicroRNAs (miRNAs) play a key role in regulating gene expression within the tumor microenvironment, influencing cancer progression and therapy response. Cancer-associated fibroblasts (CAFs) contribute to tumor...

    Authors: Parsa Golestannejad, Mohamadparsa Monkaresi, Farahnaz Zhian Zargaran, Mohammad Khosravani, Pouya Asgari, Hesam Mobaraki, Mansour Gorjizad, Saina Hasany, Aliakbar Senobari Ghezeljehmeidan, Sara Hemmati, Samaneh Zand, Parsa Ghasemi and Mahsa Asadi Anar
    Citation: BMC Cancer 2025 25:582
    Content type: Systematic Review Published on:

  15. To quantitatively investigate the pathological subtypes of lacrimal gland adenoid cystic carcinoma (LGACCs), the tumor immune microenvironment in each pathological subtype, and the relation to survival.

    Authors: Yi Zhang, Zhipeng Guo, Jie Sun, Yingwen Bi, Rongrong Cai, Rui Zhang, Hui Ren, Jiang Qian and Fengxi Meng
    Citation: BMC Cancer 2025 25:581
    Content type: Research Published on:

  16. N6-methyladenosine (m6A) and ferroptosis are involved in the development and prognosis of various cancers via long noncoding RNAs (lncRNAs). This study aimed to investigate the cervical cancer subtypes based o...

    Authors: Kaiting Wen, Lili Wang, Huancheng Su, Lijun Yu, Sanyuan Zhang, Meiyan Wei, Yaling Wang, Le Zhao and Yan Guo
    Citation: BMC Cancer 2025 25:580
    Content type: Research Published on:

  17. The prognostic significance of vagal nerve (VN) activity, as measured by heart rate variability (HRV) in cancer patients remains a subject of debate. The aim of this meta-analysis was to evaluate the associati...

    Authors: Wen-Bo Huang, Heng-zhou Lai, Jing Long, Qiong Ma, Xi Fu, Feng-Ming You and Chong Xiao
    Citation: BMC Cancer 2025 25:579
    Content type: Systematic Review Published on:

  19. A novel molecular diagnostic test, Percepta Nasal Swab (PNS), was developed as a noninvasive lung cancer biomarker to aid in risk assessment for indeterminate pulmonary nodules in individuals who smoke or have...

    Authors: Shuyang Wu, Ruochen Jiang, Grazyna Fedorowicz, Mei Wong, Janna S. Chamberlin, Lori Lofaro, P. Sean Walsh, Giulia C. Kennedy, Yangyang Hao, Jing Huang and Bill Bulman
    Citation: BMC Cancer 2025 25:577
    Content type: Research Published on:

  20. Despite significant advancements in the field of immunotherapy for esophageal cancer in recent years, only a minority of patients respond to these treatments, and effective predictive biomarkers remain elusive...

    Authors: Suyao Li, Yongling Yu, Yirong Xu, Yue Zhou, Junxing Huang and Jinghao Jia
    Citation: BMC Cancer 2025 25:576
    Content type: Research Published on:

  21. Clear cell Carcinoma (ccRCC) is the most common and lethal subtype among renal cancers. In the present study we investigated the potential role of fatty acid-binding protein 4 (FABP4), also known as adipocyte ...

    Authors: Evelina La Civita, Rosa Sirica, Felice Crocetto, Matteo Ferro, Francesco Lasorsa, Giuseppe Lucarelli, Ciro Imbimbo, Pietro Formisano, Francesco Beguinot and Daniela Terracciano
    Citation: BMC Cancer 2025 25:575
    Content type: Research Published on:

  22. In the context of surgical treatment for rectal cancer, the dentate line is acknowledged as a critical anatomical landmark. However, the prognostic implications of dentate line invasion (DLI) remain elusive an...

    Authors: Zixing Zhu, Dedi Jiang, Yujuan Jiang, Jichuan Quan, Mingguang Zhang, Wei Pei, Jianjun Bi, Qiang Feng, Haitao Zhou, Zheng Wang, Zhaoxu Zheng, Qian Liu, Zhixun Zhao and Jianwei Liang
    Citation: BMC Cancer 2025 25:574
    Content type: Research Published on:

  23. The high heterogeneity of hepatocellular carcinoma (HCC) poses challenges for precision treatment strategies. This study aims to use multi-omics methodologies to better understand its pathogenesis and discover...

    Authors: Ying-Ying Wang, Wan-Xia Yang, Jiang-Ying Cai, Fang-Fang Wang and Chong-Ge You
    Citation: BMC Cancer 2025 25:573
    Content type: Research Published on:

  24. Normal Tissue Complication Probability (NTCP) models predict temporal lobe injury risk post-intensity-modulated radiotherapy in nasopharyngeal carcinoma patients. Optimal parameter estimation methods for NTCP ...

    Authors: Huidan OuYang, Yuze Liu, Xianming He, Jianze Zhang, Lei Tao, Mengmeng Liu, Jianwu Ding, Ronghuan Hu, Jiali Hu, Zequn Huang, Su Deng, Jiayin Wu, Zhengyu Xu, Qiwei Luo and Lei Zeng
    Citation: BMC Cancer 2025 25:572
    Content type: Research Published on:

  25. Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. The prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in HCC patients has been extensively s...

    Authors: Jinxiang Peng, Haozhu Chen, Zhuang Chen, Jinmei Tan, Feng Wu and Xiaojuan Li
    Citation: BMC Cancer 2025 25:571
    Content type: Systematic Review Published on:

  27. This retrospective study report the clinical experience of eye-preserving treatment follow by particle beam radiotherapy (IMPT or CIRT) for orbital malignancies. And to evaluate prognostic factors for orbital ...

    Authors: Weixu Hu, Qiong Cai, Jing Gao, Jiyi Hu, Qingting Huang, Haojiong Zhang and Lin Kong
    Citation: BMC Cancer 2025 25:569
    Content type: Research Published on:

  29. The impact of Helicobacter pylori (H. pylori) status on gastric cancer survival remains unclear. In this study, we conducted a prognostic analysis of 488 gastric cancer patients and performed single-cell RNA sequ...

    Authors: Zhisheng Wu, Xinya Wang, Shujing Shi, Deyuan Kong, Chuanli Ren, Lijun Bian, Yuanliang Gu, Fangmei An, Qiang Zhan, Caiwang Yan, Chupeng Hu, Yun Chen, Runqiu Jiang and Jinfei Chen
    Citation: BMC Cancer 2025 25:567
    Content type: Research Published on:

  30. Depression and diet are both common modifiable factors related to mortality rates among individuals with cancer, but their combined effects remained underexplored. We aimed to comprehensively evaluate the inde...

    Authors: Zongyuan Li, Cheng Yu, Jianqi Hao, Yueli Shu, Jili Li, Jian Zhang, Qiang Pu and Lunxu Liu
    Citation: BMC Cancer 2025 25:566
    Content type: Research Published on:

  31. Immune checkpoint inhibitors (ICI) are highly effective but may induce severe or even fatal and unpredictable immune-related adverse events (irAEs). It is unclear whether human leukocyte antigen (HLA) genes co...

    Authors: Isabel Manger, Christina Schmitt, Carola Berking, Lars E. French, Julio Vera-Gonzalez and Lucie Heinzerling
    Citation: BMC Cancer 2025 25:565
    Content type: Research Published on:

  32. The efficacy of adding programmed death-1 (PD-1) inhibitors to transcatheter arterial chemoembolization (TACE) combined with apatinib for advanced hepatocellular carcinoma (HCC) remains controversial. This stu...

    Authors: Jiahui Yu, Jinxin Yu, Yimiao Chen, Yuting Yang and Pengsheng Yi
    Citation: BMC Cancer 2025 25:564
    Content type: Systematic Review Published on:

  33. Distinguishing between benign and malignant testicular lesions on clinical magnetic resonance imaging (MRI) is crucial for guiding treatment planning. However, conventional MRI-based radiomics to identify test...

    Authors: Liang Wang, PeiPei Zhang, Yanhui Feng, Wenzhi Lv, Xiangde Min, Zhiyong Liu, Jin Li and Zhaoyan Feng
    Citation: BMC Cancer 2025 25:563
    Content type: Research Published on:

  34. Von Hippel-Lindau (vHL) disease encompasses various genetic subtypes with poorly defined progression patterns. This retrospective study of a longitudinal cohort aimed to characterize follow-up duration, treatm...

    Authors: Jae Ho Lee, Hyun Young Lee, Ji Eun Park, Min-Ju Kim, Dae Wook Hwang, Sangjoon Chong, Moinay Kim, Joo Yong Lee, Cheryn Song and Beom Hee Lee
    Citation: BMC Cancer 2025 25:562
    Content type: Research Published on:

  35. Differentiating chondroid tumors is crucial for proper patient management. This study aimed to develop a deep learning model (DLM) for classifying enchondromas, atypical cartilaginous tumors (ACT), and high-gr...

    Authors: Felix G. Gassert, Daniel Lang, Nina Hesse, Hans Roland Dürr, Alexander Klein, Luca Kohll, Florian Hinterwimmer, Johanna Luitjens, Stefan Weissinger, Jan C. Peeken, Carolin Mogler, Carolin Knebel, Stefan Bartzsch, Florian T. Gassert and Alexandra S. Gersing
    Citation: BMC Cancer 2025 25:561
    Content type: Research Published on:

  37. B cells play a variety of complex roles in cancer, both promoting cancer progression and enhancing anti-tumor immune responses, but their mechanism of action in kidney cancer has not been elucidated.

    Authors: Jiaao Sun, Shiyan Song, Qiancheng Ma, Feng Chen, Xiaochi Chen and Guangzhen Wu
    Citation: BMC Cancer 2025 25:559
    Content type: Research Published on:

  38. Cancers affecting < 6/100,000/year are classified as rare, but they account for up to 25% of all cancers and are associated with worse 5-year survival than common cancers. Early-phase clinical trials (EPCTs) m...

    Authors: Angelos Angelakas, Natalie Cook, Donna M. Graham, Matthew Krebs, Fiona Thistlethwaite and Louise Carter
    Citation: BMC Cancer 2025 25:558
    Content type: Research Published on:

  39. Recent studies have identified a complex relationship between methylation patterns and the development of various cancers. Breast cancer (BC) is the second leading cause of cancer mortality among women. Approx...

    Authors: Song Wang, Jianran Guo, Xinmiao Xian, Min Li, Anqi Zhang, Yujiao Liu, Yifei Zhang, Shen Chen, Guohao Gu, Xuehua Zhang, Dong Yan, Meng An, Li Pan and Bo Fu
    Citation: BMC Cancer 2025 25:557
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2025 25:625

  40. To investigate the causal relationship between type 2 diabetes mellitus (T2DM), pancreatic cancer (PC) risk and identify the mediating effects of various risk factors on that relationship.

    Authors: Yuxin Wang, Lu Xie, Ye Gu, Hangbin Jin, Jianfeng Yang, Qiang Liu and Xiaofeng Zhang
    Citation: BMC Cancer 2025 25:556
    Content type: Research Published on:

  41. Colorectal cancer (CRC) ranks as the second most prevalent malignancy globally, highlighting the urgent need for more effective diagnostic and therapeutic strategies, as well as a deeper understanding of its m...

    Authors: Marie Boudná, Nicolas Blavet, Tetiana Samoilenko, Táňa Macháčková, Robin Jugas, Petra Vychytilová-Faltejsková, Miroslav Boudný, Renata Bartošová, Jan Kotouček, Vojtěch Bystrý, Kateřina Koželková, Ondřej Slabý and Kamila Součková
    Citation: BMC Cancer 2025 25:555
    Content type: Research Published on:

  43. Colorectal cancer rising incidence still pose a public health challenge. In the present systematic review, we aimed to study the colorectal cancer patients with initial presentation of rectal prolapse.

    Authors: Fatemeh Shahabi, Abbas Abdollahi, Mahdieh Zarif-Sadeghian, Dorin Ziyaie, Ehsan Rahimpour, Majid Ansari and Esmat Davoudi-Monfared
    Citation: BMC Cancer 2025 25:553
    Content type: Systematic Review Published on:

  44. Catheter-related thrombosis (CRT) is a serious complication in cancer patients undergoing chemotherapy, yet existing risk prediction models demonstrate limited accuracy. This study aimed to evaluate the clinic...

    Authors: Tao An, Han Han, Junying Xie, Yifan Wang, Yiqi Zhao, Hao Jia and Yanfeng Wang
    Citation: BMC Cancer 2025 25:552
    Content type: Research Published on:

  45. In cases of prevalent lymphadenopathy in the head and neck cancer region, identifying the primary tumor site allows for more precise radiotherapy targeting. This improves treatment by reducing the volumes of m...

    Authors: Vianney Bastit, Justine Lequesne, Alexandra Leconte, Sophie Deneuve, Francois Mouawad, Elske Quak, Corinne Jeanne, Bénédicte Clarisse and Juliette Thariat
    Citation: BMC Cancer 2025 25:551
    Content type: Study Protocol Published on:

  46. Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, with significant differences in incidence and outcomes between men and women. Estrogen receptor alpha (ERα) expression is associated ...

    Authors: De-Hua Wang, Dong-Wei He, Ting-Ting Lv, Xiao-Kuan Zhang, Zi-Jie Li and Zhi-Yu Wang
    Citation: BMC Cancer 2025 25:550
    Content type: Research Published on:

  48. Breast cancer (BC) is the most prevalent cancer among women in both developed and developing countries. Breast self-examination (BSE) is crucial for the early detection of BC. This study aimed to assess the ef...

    Authors: Halime Cheraghalizadeh, Hajar Adib-Rad, Hajar Pasha, Mohammad Chehrazi, Fatemeh Nasiri‑Amiri and Shabnam Omidvar
    Citation: BMC Cancer 2025 25:548
    Content type: Research Published on:

  49. L-arginine limits proliferation in highly proliferative tissues. It is a substrate for nitric oxide synthases, arginases; its methylation by protein-L-arginine methyltransferases (PRMTs) leads to asymmetric (A...

    Authors: Juliane Hannemann, Leticia Oliveira-Ferrer, Anne Kathrin Goele, Yoana Mileva, Fiona Kleinsang, Antonia Röglin, Isabell Witzel, Volkmar Müller and Rainer Böger
    Citation: BMC Cancer 2025 25:546
    Content type: Research Published on:

  50. Despite theoretical advantages, skepticism persists about robotic rectal cancer surgery due to the lack of evidence of benefit. This study aims to compare oncological and functional results of robotic-assisted...

    Authors: Xiaojie Wang, Yangyang Wang, Zhifen Chen, Zhifang Zheng, Shenghui Huang, Yanwu Sun, Ying Huang and Pan Chi
    Citation: BMC Cancer 2025 25:545
    Content type: Research Published on:

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