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  1. Ovarian cancer (OC), as a malignant tumor, currently lacks effective screening early diagnosis measures. Clinical biomarkers CA-125 and HE4 are limited by false positives and insufficient sensitivity. Therefor...

    Authors: Lingxi Tian, Yan Gao, Lihan Zi, Ruilian Zhe and Jun Yang
    Citation: BMC Cancer 2025 25:695
    Content type: Research Published on:

  2. Laryngeal cancer (LC) is a malignant tumor that occurs in the larynx. N6-methyladenosine (m6A) RNA methylation, a pivotal and prevalent epigenetic modification in eukaryotic mRNA, intricately intertwines with ...

    Authors: Xin Wang, Wen Zhang, Kun Liang, Yujuan Wang, Jin Zhang, Jinping Wang, An Li, Yonggang Yun, Hiu Liu and Yanan Sun
    Citation: BMC Cancer 2025 25:694
    Content type: Research Published on:

  3. Identifying occult central lymph node metastasis (CLNM) is essential for guiding prophylactic lymph node dissection (PLND) in patients with cN0 stage papillary thyroid microcarcinoma (PTMC). This study aimed t...

    Authors: Jinqiu Wang, Weida Fu, Jin Luo, Mingze Wei and Yongping Dai
    Citation: BMC Cancer 2025 25:693
    Content type: Research Published on:

  4. The relationship between cytokines and lung metastasis (LM) in breast cancer (BC) remains unclear and current clinical methods for identifying breast cancer lung metastasis (BCLM) lack precision, thus undersco...

    Authors: Zhaoyi Li, Hao Miao, Wei Bao and Lansheng Zhang
    Citation: BMC Cancer 2025 25:692
    Content type: Research Published on:

  5. The use of immune checkpoint inhibitors (ICIs) combined with chemotherapy constitutes the first-line treatment for recurrent or metastatic nasopharyngeal carcinoma (RM-NPC). However, elderly patients are under...

    Authors: Rui-Ling Xie, Wu-Lin Cai, Yan-Feng Ouyang, Ye-Hao Zou and Rui Sun
    Citation: BMC Cancer 2025 25:691
    Content type: Research Published on:

  7. The study investigated the response of immune cells, particularly natural killer (NK) cells and innate lymphoid cells (ILCs), to acute exercise in adolescents and young adults (AYAs) undergoing cancer treatmen...

    Authors: Isabella Deppe, Ronja Beller, Fabian Kiehl, Nico De Lazzari, Sabrina B. Bennstein, Dirk Reinhardt, Uta Dirksen and Miriam Götte
    Citation: BMC Cancer 2025 25:689
    Content type: Research Published on:

  8. The Cms1 ribosomal small subunit homolog (CMSS1), an RNA-binding protein (RBP), plays a crucial role in tumor development. However, the prognostic and immunological role of CMSS1 in non-small cell lung cancer (NS...

    Authors: Zhe Fan, Wanyu Liu, Zhiwei Gao, Youfa Liu, Hongyang Hai and Zhenyang Lv
    Citation: BMC Cancer 2025 25:688
    Content type: Research Published on:

  9. Authors: Alexandra Roux, Lucile Hervouet, Francesca Di Stefano, David P. French, Livia Giordano, David Ritchie, Marie-Eve Rougé Bugat, Debbie Keatley, Rachel Cholerton, Lorna McWilliams, Paolo Giorgi Rossi, Corinne Balleyguier, Michal Guindy, Fiona J. Gilbert, Jean-Benoit Burrion, Marta Roman…
    Citation: BMC Cancer 2025 25:687
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2025 25:483

  10. The clinical characteristics of immune checkpoint inhibitors (ICIs)-related myocarditis in lung cancer remains uncertain. The purpose of this study was to evaluate the incidence, clinical characteristics, risk...

    Authors: Wenli Cao, Sen Han, Panpan Zhang, Lan Mi, Yang Wang, Jun Nie, Ling Dai, Weiheng Hu, Jie Zhang, Xiaoling Chen, Xiangjuan Ma, Guangming Tian, Jindi Han, Di Wu, Jieran Long, Ziran Zhang…
    Citation: BMC Cancer 2025 25:685
    Content type: Research Published on:

  11. Cervical cancer (CC) is the third most common cancer among women worldwide and the second most prevalent neoplasm in Mato Grosso, Brazil, in 2020. This study aimed to analyze overall survival (OS), identify pr...

    Authors: Sancho Pedro Xavier, Noemi Dreyer Galvão, Marco Aurélio Bertúlio das Neves, Kátia Moreira da Silva, Adila de Queiroz Neves Almeida and Ageo Mario Cândido da Silva
    Citation: BMC Cancer 2025 25:684
    Content type: Research Published on:

  12. This study was undertaken to develop and validate a radiomics model based on multiparametric magnetic resonance imaging (MRI) for predicting recurrence in patients with hepatocellular carcinoma (HCC) following...

    Authors: Xinyu Guo, Jingjing Song, Lingyi Zhu, Shuang Liu, Chaoming Huang, Lingling Zhou, Weiyue Chen, Guihan Lin, Zhongwei Zhao, Jianfei Tu, Minjiang Chen, Feng Chen, Liyun Zheng and Jiansong Ji
    Citation: BMC Cancer 2025 25:683
    Content type: Research Published on:

  13. Understanding and managing radiation-induced adverse events is becoming increasingly important in hypofractionated radiotherapy due to the use of higher doses per fraction compared with conventional radiothera...

    Authors: Naoaki Kondo, Takashi Yoshiura, Yasumasa Kakinohana, Mayumi Yamashita, Takeshi Arimura and Takashi Ogino
    Citation: BMC Cancer 2025 25:682
    Content type: Research Published on:

  16. Global Leadership Initiative in Sarcopenia (GLIS) has recently established a conceptional definition of sarcopenia, which incorporated muscle strength, mass, and muscle-specific strength as three components of...

    Authors: Gao-Feng Wu, Chen-Hao He, Wen-Tao Xi, Wen-Bo Zhai, Zong-Ze Li, Ye-Cheng Zhu, Xiu-Bo Tang, Xia-Lin Yan, Gordon S. Lynch, Xian Shen and Dong-Dong Huang
    Citation: BMC Cancer 2025 25:679
    Content type: Research Published on:

  18. Loss of chromosome Y (LOY) has recently been proposed to be associated with cancer aggressiveness, altered T-cell function, and poor prognosis in bladder carcinomas.

    Authors: Henning Plage, Viktoria Ahlburg, Sebastian Hofbauer, Kira Furlano, Sarah Weinberger, Annika Fendler, Florian Roßner, Simon Schallenberg, Sefer Elezkurtaj, Niclas C. Blessin, Maximilian Lennartz, Andreas H. Marx, Henrik Samtleben, Margit Fisch, Michael Rink, Marcin Slojewski…
    Citation: BMC Cancer 2025 25:677
    Content type: Research Published on:

  19. The quality control testing component and main active ingredient of Polygonum multiflorum Thunb. (P. multiflorum), known as trans-2,3,5,4ʹ-tetrahydroxystilbene 2-O-β-D-glucopyranoside (TSG), exhibits diverse b...

    Authors: Xiaomeng Lin, Hua Yang, Tingting Cai, Zhangshuo Yang, Siyun Niu and Hui Jia
    Citation: BMC Cancer 2025 25:676
    Content type: Research Published on:

  20. We developed and refined an S-1 dosage formula based on renal function, sex, and body surface area (BSA) to achieve the target area under the concentration–time curve of 5-fluorouracil in two prospective pharm...

    Authors: Keisuke Baba, Nobumi Suzuki, Chiyo K. Imamura, Eisuke Booka, Masashi Takeuchi, Daisuke Takahari, Takeshi Kawakami, Hirofumi Kawakubo, Chiyoe Kitagawa, Yoshiyasu Kono, Keiji Ogura, Yosuke Kito, Kei Saito, Shinzo Yamamoto, Hiroya Takeuchi, Toshihiro Kudo…
    Citation: BMC Cancer 2025 25:675
    Content type: Study Protocol Published on:

  21. Immunoneoadjuvant therapy has gained significant attention due to its remarkable advancements in cancer treatment. This study aimed to investigate the molecular mechanisms underlying immunoneoadjuvant therapy ...

    Authors: Chengjuan Zhang, Tingjie Wang, Jing Yuan, Tao Wang, Bin Ma, Benling Xu, Ruihua Bai, Xiance Tang, Xiaojie Zhang, Minqing Wu, Tianqi Lei, Wenhao Xu, Yongjun Guo and Ning Li
    Citation: BMC Cancer 2025 25:674
    Content type: Research Published on:

  22. Adenosine A2B receptor (ADORA2B), a G protein-coupled receptor, is implicated in tumor progression and immune regulation in various cancers. However, its specific role in head and neck squamous cell carcinoma ...

    Authors: Pian Li, Ke-ling Pang, Shuang-jing Chen, Dong Yang, Ai-tao Nai, Gui-cheng He, Zhe Fang, Qiao Yang, Man-bo Cai and Jun-yan He
    Citation: BMC Cancer 2025 25:673
    Content type: Research Published on:

  23. Digestive system cancers remain a leading cause of cancer-related mortality globally, underscoring the need for reliable prognostic tools. The C-reactive protein-Albumin-Lymphocyte (CALLY) index, which reflect...

    Authors: Bo Wu, Jingting Liu, Chaodan Shao, Dongli Yu and Jianhua Liao
    Citation: BMC Cancer 2025 25:672
    Content type: Systematic Review Published on:

  24. The prognostic and predictive value of obesity and sarcopenia remains poorly defined in patients with high-risk soft tissue sarcoma (HR-STS). We sought to correlate clinical outcomes with CT-based body composi...

    Authors: Luc M. Berclaz, Dorit Di Gioia, Michael Völkl, Vindi Jurinovic, Alexander Klein, Hans Roland Dürr, Thomas Knösel, Bianca Teodorescu, Stefan Enßle, Michaela Rippl, Michael von Bergwelt-Baildon, Wolfgang G. Kunz, Lars H. Lindner and Anton Burkhard-Meier
    Citation: BMC Cancer 2025 25:671
    Content type: Research Published on:

  25. Our previous trial integrating cognitive behavioural therapy with activity pacing (CBT-AP) demonstrated the efficacy of CBT-AP in reducing cancer-related fatigue and depression, as well as improving the qualit...

    Authors: Mikiyas Amare Getu, Mirgissa Kaba, Adamu Addissie, Edom Seife, Panpan Wang, Xianbin Zhang, Changying Chen and Eva Johanna Kantelhardt
    Citation: BMC Cancer 2025 25:670
    Content type: Research Published on:

  26. Only a limited number of biomarkers guide personalized management of pancreatic neuroendocrine tumors (PanNETs). Transcriptome profiling of microRNA (miRs) and mRNA has shown value in segregating PanNETs and i...

    Authors: N Matyasovska, N Valkova, M Gala, S Bendikova, A Abdulhamed, V. Palicka, Neil Renwick, Pavol Čekan and Evan Paul
    Citation: BMC Cancer 2025 25:669
    Content type: Research Published on:

  27. Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by poor prognosis and limited treatment options, which underscores the urgency of the discovery of new biomarkers. M...

    Authors: Weibin Ren, Yuyun Yu, Tao Wang, Xueyao Wang, Kunkai Su, Yanbo Wang, Wenjie Tang, Miaomiao Liu, Yanhui Zhang, Long Yang and Hongyan Diao
    Citation: BMC Cancer 2025 25:668
    Content type: Research Published on:

  28. This study aimed to investigate the use of in vivo dose validation during post-breast-conserving radiation for early breast cancer, the impact of image guidance on validation outcomes, and the role of inter- a...

    Authors: Wanli Zhu, Jia Fang, Yi Zhang, Meiqin Chen, Hongzhi Zhang and Shubo Ding
    Citation: BMC Cancer 2025 25:667
    Content type: Research Published on:

  30. Frailty models are extensively utilized in survival analysis to address unobserved heterogeneity among individuals. However, selecting the most robust model for survival prediction, especially in the context o...

    Authors: Senyefia Bosson-Amedenu, Emmanuel Ayitey, Francis Ayiah-Mensah and Luyton Asare
    Citation: BMC Cancer 2025 25:665
    Content type: Research Published on:

  31. The study aimed to assess the value of pretreatment peripheral blood neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and systemic immune-inflammation index/albumin ratio (SII/ALB) for predic...

    Authors: Yan Lei, Chengsong Cao, Rui Tang and Yong Liu
    Citation: BMC Cancer 2025 25:664
    Content type: Research Published on:

  32. Entamoeba histolytica remains a significant cause of global mortality. The involvement of protozoa in microsatellite instability (MSI) and the potential of miRNA-643 as biomarkers for amoebic and colorectal disea...

    Authors: Leila Haghighi, Abdolhossein Dalimi, Majid Pirestani and Fatemeh Ghaffarifar
    Citation: BMC Cancer 2025 25:663
    Content type: Research Published on:

  33. PANoptosis, a complex programmed cell death (PCD) pathway that includes apoptosis, pyroptosis and necroptosis, is significantly involved in the progression of cancers. Long noncoding RNAs (lncRNAs) play crucia...

    Authors: Yuekai Cui, Jie Mei, Shengsheng Zhao, Bingzi Zhu, Jianhua Lu, Hongzheng Li, Binglong Bai, Weijian Sun, Wenyu Jin, Xueqiong Zhu, Shangrui Rao and Yongdong Yi
    Citation: BMC Cancer 2025 25:662
    Content type: Research Published on:

  34. hnRNPA3 is highly expressed in numerous malignancies, including hepatocellular carcinoma (HCC), but its function and mechanism has not been elucidated. In this study, we performed a comprehensive bioinformatic...

    Authors: Xufan Cai, Weihui Guo, Fang Wu, Weilang Xu, Tao Ding, Yizhe Diao, Lei Wang, Zhenyuan Qian and Guangyuan Song
    Citation: BMC Cancer 2025 25:661
    Content type: Research Published on:

  35. Pregnancy-Associated Breast Cancer (PABC) is a special type of breast cancer that either occurs during pregnancy or one year postpartum. The aim of this systematic review and meta-analysis is to investigate th...

    Authors: Mohammad Akhlaqi, Amirali Ghofrani, Nazila Najdi, Mohammadhosein Ranjkesh and Amir Almasi-Hashiani
    Citation: BMC Cancer 2025 25:660
    Content type: Systematic Review Published on:

  36. The infiltration status of pulmonary ground-glass nodules (GGNs) exhibits significant variability, demanding tailored surgical strategies and individualized postoperative adjuvant therapies. This study explore...

    Authors: Kun Mei, Zikang Feng, Hui Liu, Min Wang, Chao Ce, Shi Yin, Xiaoying Zhang and Bin Wang
    Citation: BMC Cancer 2025 25:659
    Content type: Research Published on:

  37. Targeting RAS mutant (MT) colorectal cancer (CRC) remains a difficult challenge, mainly due to the pervasiveness of RAS/MEK-mediated feedback loops. Preclinical studies identified MET/STAT3 as an important mediat...

    Authors: Francesca Aroldi, Elena Elez, Thierry André, Geraldine Perkins, Hans Prenen, Vlad Popovici, Peter Gallagher, Jennifer Houlden, Linda Collins, Corran Roberts, Christian Rolfo, Federica Di Nicolantonio, Margaret Grayson, Ruth Boyd, Karolien Bettens, Jurgen Delfavero…
    Citation: BMC Cancer 2025 25:658
    Content type: Research Published on:

  39. The composition of the gut microbiota both prior to and after haematopoietic stem cell transplantation (HSCT) is increasingly implicated in the outcomes of HSCT, including infections, poor immune reconstitutio...

    Authors: Anna Li, Sam P. Costello, Robert V. Bryant, Sarah Haylock-Jacobs, Craig Haifer, Cindy Lee, David Yeung, Pratyush Giri, Danielle Blunt, Joanne B. Bowen, Feargal J. Ryan, Angelina Yong and Hannah R. Wardill
    Citation: BMC Cancer 2025 25:656
    Content type: Study Protocol Published on:

  40. Pancreatic cancer is highly aggressive and sensitive to acidic microenvironments, which promote cancer cell survival and invasion. Long non-coding RNAs (lncRNAs) play crucial roles in cancer biology, helping c...

    Authors: Deyang Mu, Ying Shi, Runxuan Sun, Bing Han, Kai Zhong, Yilu Ye and Jungang Zhang
    Citation: BMC Cancer 2025 25:655
    Content type: Research Published on:

  41. Glioblastoma (GBM), one of the most aggressive brain tumors, has a 5-year survival rate of less than 5%. Current standard therapies, including surgery, radiotherapy, and temozolomide (TMZ) chemotherapy, are li...

    Authors: Hongwei Zhang, Zixuan Wang, Xiaolong Qiao, Jiaxing Wu and Chuandong Cheng
    Citation: BMC Cancer 2025 25:654
    Content type: Research Published on:

  42. The current standard first-line treatment for patients with advanced biliary tract cancer (BTC) is a combination chemotherapy regimen. However, whether the efficacy of combination therapy is superior to that o...

    Authors: Ritsuko Oishi, Satoshi Kobayashi, Shuhei Nagashima, Taito Fukushima, Shun Tezuka, Manabu Morimoto, Makoto Ueno and Shin Maeda
    Citation: BMC Cancer 2025 25:653
    Content type: Research Published on:

  43. To explore the clinical significance of albumin(Alb) to the derive(d) neutrophil-to-lymphocyte ratio(NLR) in patients with esophageal squamous cell carcinoma (ESCC) aged 60 years and above.

    Authors: Xiaoqin Xu, Ting Sun, Xiaofang Zhang, Weigang Wang, Yanfen Ji and Jiexian Jing
    Citation: BMC Cancer 2025 25:652
    Content type: Research Published on:

  44. Despite significant advancements in therapy of multiple myeloma (MM) over the past 20 years, most patients experience relapse, necessitating new treatment approaches. This study aims to compare the real-world ...

    Authors: Jiri Minarik, Ludek Pour, Vojtech Latal, Tomas Jelinek, Jan Straub, Alexandra Jungova, Jakub Radocha, Petr Pavlicek, Martin Stork, Tomas Pika, Petra Krhovska, Tereza Popkova, Frantisek Sedlak, Ivan Spicka, Pavel Jindra, Vladimira Capounova…
    Citation: BMC Cancer 2025 25:651
    Content type: Research Published on:

  46. Patient-derived xenografts and organoids were the most common patient-derived tumor models in vitro that were utilized in personalized drug screening, and the establishment rate and duration required to be imp...

    Authors: Sheng Xu, Shen-Yi Yin, Zhi-Xin Bie, Yuan-Ming Li, Jing Qi, Yi-Dan Ma, Zheng Wang, Jianzhong Jeff Xi and Xiao-Guang Li
    Citation: BMC Cancer 2025 25:649
    Content type: Research Published on:

  47. The assessment of immunotherapy plays a pivotal role in the clinical management of skin melanoma. Graph neural networks (GNNs), alongside other deep learning algorithms and bioinformatics approaches, have demo...

    Authors: Maodong Ye, Shuai Ren, Huanjuan Luo, Xiumin Wu, Hongwei Lian, Xiangna Cai and Yingchang Ji
    Citation: BMC Cancer 2025 25:648
    Content type: Research Published on:

  48. This study aimed to evaluate the prognostic factors influencing the survival of patients with lung cancer identified from a lung cancer screening cohort in the community.

    Authors: Jun Li, Hui-Lin Xu, Wei-Xi Li, Xiao-Yu Ma, Xiao-Hua Liu and Zuo-Feng Zhang
    Citation: BMC Cancer 2025 25:646
    Content type: Research Published on:

  50. Gastric cancer (GC) is a highly aggressive and heterogeneous cancer with extremely complex biological characteristics. Lysine and its metabolism are closely related to human cancer, but little is known about h...

    Authors: Yongfu Shao, Chujia Chen, Xuan Yu, Jianing Yan, Junming Guo and Guoliang Ye
    Citation: BMC Cancer 2025 25:644
    Content type: Research Published on:

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