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  1. Recent studies have identified a complex relationship between methylation patterns and the development of various cancers. Breast cancer (BC) is the second leading cause of cancer mortality among women. Approx...

    Authors: Song Wang, Jianran Guo, Xinmiao Xian, Min Li, Anqi Zhang, Yujiao Liu, Yifei Zhang, Shen Chen, Guohao Gu, Xuehua Zhang, Dong Yan, Meng An, Li Pan and Bo Fu
    Citation: BMC Cancer 2025 25:557
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2025 25:625

  2. To investigate the causal relationship between type 2 diabetes mellitus (T2DM), pancreatic cancer (PC) risk and identify the mediating effects of various risk factors on that relationship.

    Authors: Yuxin Wang, Lu Xie, Ye Gu, Hangbin Jin, Jianfeng Yang, Qiang Liu and Xiaofeng Zhang
    Citation: BMC Cancer 2025 25:556
    Content type: Research Published on:

  3. Colorectal cancer (CRC) ranks as the second most prevalent malignancy globally, highlighting the urgent need for more effective diagnostic and therapeutic strategies, as well as a deeper understanding of its m...

    Authors: Marie Boudná, Nicolas Blavet, Tetiana Samoilenko, Táňa Macháčková, Robin Jugas, Petra Vychytilová-Faltejsková, Miroslav Boudný, Renata Bartošová, Jan Kotouček, Vojtěch Bystrý, Kateřina Koželková, Ondřej Slabý and Kamila Součková
    Citation: BMC Cancer 2025 25:555
    Content type: Research Published on:

  4. Colorectal cancer rising incidence still pose a public health challenge. In the present systematic review, we aimed to study the colorectal cancer patients with initial presentation of rectal prolapse.

    Authors: Fatemeh Shahabi, Abbas Abdollahi, Mahdieh Zarif-Sadeghian, Dorin Ziyaie, Ehsan Rahimpour, Majid Ansari and Esmat Davoudi-Monfared
    Citation: BMC Cancer 2025 25:553
    Content type: Systematic Review Published on:

  5. Catheter-related thrombosis (CRT) is a serious complication in cancer patients undergoing chemotherapy, yet existing risk prediction models demonstrate limited accuracy. This study aimed to evaluate the clinic...

    Authors: Tao An, Han Han, Junying Xie, Yifan Wang, Yiqi Zhao, Hao Jia and Yanfeng Wang
    Citation: BMC Cancer 2025 25:552
    Content type: Research Published on:

  6. Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, with significant differences in incidence and outcomes between men and women. Estrogen receptor alpha (ERα) expression is associated ...

    Authors: De-Hua Wang, Dong-Wei He, Ting-Ting Lv, Xiao-Kuan Zhang, Zi-Jie Li and Zhi-Yu Wang
    Citation: BMC Cancer 2025 25:550
    Content type: Research Published on:

  8. Breast cancer (BC) is the most prevalent cancer among women in both developed and developing countries. Breast self-examination (BSE) is crucial for the early detection of BC. This study aimed to assess the ef...

    Authors: Halime Cheraghalizadeh, Hajar Adib-Rad, Hajar Pasha, Mohammad Chehrazi, Fatemeh Nasiri‑Amiri and Shabnam Omidvar
    Citation: BMC Cancer 2025 25:548
    Content type: Research Published on:

  9. Although metabolic syndrome (MetS) is associated with an increased risk of various cancers, the combined impact of MetS and healthy lifestyle factors (HLF) on cancer risk is unclear. This study aimed to invest...

    Authors: Feng Lin, Wen Hu, Chenfenglin Yang, Binglin Cheng, Hongfan Chen, Jiaxin Li, Hanrui Zhu, Haixiang Zhang, Xiang Yuan, Xianyue Ren, Xiaohong Hong and Xinran Tang
    Citation: BMC Cancer 2025 25:547
    Content type: Research Published on:

  10. L-arginine limits proliferation in highly proliferative tissues. It is a substrate for nitric oxide synthases, arginases; its methylation by protein-L-arginine methyltransferases (PRMTs) leads to asymmetric (A...

    Authors: Juliane Hannemann, Leticia Oliveira-Ferrer, Anne Kathrin Goele, Yoana Mileva, Fiona Kleinsang, Antonia Röglin, Isabell Witzel, Volkmar Müller and Rainer Böger
    Citation: BMC Cancer 2025 25:546
    Content type: Research Published on:

  11. Despite theoretical advantages, skepticism persists about robotic rectal cancer surgery due to the lack of evidence of benefit. This study aims to compare oncological and functional results of robotic-assisted...

    Authors: Xiaojie Wang, Yangyang Wang, Zhifen Chen, Zhifang Zheng, Shenghui Huang, Yanwu Sun, Ying Huang and Pan Chi
    Citation: BMC Cancer 2025 25:545
    Content type: Research Published on:

  13. Systemic inflammation has prognostic value in cancer and is considered aetiological of cachexia by the Global Leadership Initiative on Malnutrition (GLIM). Lactate dehydrogenase (LDH) also has recognized progn...

    Authors: Joshua J. Thompson, Nicholas MacLeod, Sarah Will, Fraser O’Rourke, Josh McGovern, Campbell Roxburgh, Joanne Edwards, Ross D. Dolan and Donald C. McMillan
    Citation: BMC Cancer 2025 25:543
    Content type: Research Published on:

  14. The role of sodium-glucose co-transporter 2 inhibitor (SGLT2i) drugs in the management of diabetes and cardiovascular disease is well-established, but emerging evidence suggests potential effects on cancer out...

    Authors: Lucas E. Flausino, Alexis Germán Murillo Carrasco, Tatiane Katsue Furuya, Wen-Jan Tuan and Roger Chammas
    Citation: BMC Cancer 2025 25:542
    Content type: Research Published on:

  15. Immune checkpoint inhibitors (ICIs) have revolutionized treatment for advanced lung cancer, yet their cardiotoxicity, particularly immune checkpoint inhibitor-related myocarditis, poses significant clinical ch...

    Authors: Shanshan Li, Feng Du, Yan Zhang, Qiang Wang, Jianjian Dou and Xiangjiao Meng
    Citation: BMC Cancer 2025 25:541
    Content type: Research Published on:

  16. Claudin 18.2 (CLDN18.2), a tight junction protein predominantly expressed in the normal gastric epithelium, has recently emerged as a potential therapeutic target in various solid tumors. Despite growing inter...

    Authors: Nah Ihm Kim, Joo Yeon Koo, Sung Sun Kim, Ji Young Lee, Ji Shin Lee, Hyun Jin Bang, Woo Kyun Bae, Tae Mi Yoon, Kyung-Sub Moon, Jae-Hyuk Lee and Kyung-Hwa Lee
    Citation: BMC Cancer 2025 25:540
    Content type: Research Published on:

  17. Systemic inflammation and nutritional status are key factors affecting the prognosis of patients with cancer cachexia. This study aims to evaluate the prognostic value of a new nutritional and inflammatory ind...

    Authors: Xiangrui Li, Li Deng, Hailun Xie, Shuqun Li, Hong Zhao, Tong Liu, Xiaoyue Liu, Shiqi Lin, ChengAn Liu and Han-Ping Shi
    Citation: BMC Cancer 2025 25:539
    Content type: Research Published on:

  19. In view of inherent attributes of breast BI-RADS 3, benign and malignant lesions are with a subtle difference and the imbalanced ratio (with a very small part of malignancy). The objective of this study is to ...

    Authors: Huanhuan Tian, Li Cai, Yu Gui, Zhigang Cai, Xianfeng Han, Jianwei Liao, Li Chen and Yi Wang
    Citation: BMC Cancer 2025 25:537
    Content type: Research Published on:

  20. In this study, we retrospectively analyzed the incidence of and risk factors for in-hospital venous thromboembolism (VTE) in patients with bladder cancer and explored measures to reduce the incidence of and/or...

    Authors: Huitang Yang, Tonghe Zhang, Zhaoyang Li, Yandong Cai, Zhan Jiang, Guoju Fan, Kaiqiang Wang, Bo Chen, Hongwei Zhang, Hailong Hu and Yankui Li
    Citation: BMC Cancer 2025 25:536
    Content type: Research Published on:

  21. Despite advancements in the detection and treatment of prostate cancer, the molecular mechanisms underlying its progression remain unclear. This study aimed to investigate the role of the receptor OR51E2, whic...

    Authors: Mikkel Thy Thomsen, Morten Busk, Dalin Zhang, Chun-Lung Chiu, Hongjuan Zhao, Fernando Jose Garcia-Marques, Abel Bermudez, Sharon Pitteri, Michael Borre, James D. Brooks and Jens Randel Nyengaard
    Citation: BMC Cancer 2025 25:535
    Content type: Research Published on:

  22. Psoriasis is a chronic inflammatory skin condition mediated by autoimmune processes, which may heighten the susceptibility to infections. However, its impact on infection risk and survival outcomes in patients...

    Authors: Lin Jian, Mu-Kuan Chen, Chew-Teng Kor and Yen-Tze Liu
    Citation: BMC Cancer 2025 25:534
    Content type: Research Published on:

  23. This study aimed to elucidate the expression profile and biological implications of peroxidase 5 (PRDX5) in bladder cancer (BC), specifically investigating its influence on BC progression through modulation of...

    Authors: Shun Wan, Kun-peng Li, Si-yu Chen, Chen-yang Wang, Kun Cheng, Jian-wei Yang, Li-yun Ding, Tuan-jie Che, Shan-hui Liu and Li Yang
    Citation: BMC Cancer 2025 25:533
    Content type: Research Published on:

  24. Haematological cancer affects more than 1.3 million people around the world annually and accounted for almost 800,000 deaths globally in 2020. The number of patients with these cancers undergoing bone marrow t...

    Authors: Linda Denehy, Shaza Abo, Christopher Swain, Camille E. Short, Nicole Kiss, Amit Khot, Eric Wong, Duncan Purtill, Clare O’Donnell, Marlena Klaic, Catherine L. Granger, Michelle Tew, Tim Spelman, Vinicius Cavalheri and Lara Edbrooke
    Citation: BMC Cancer 2025 25:532
    Content type: Study Protocol Published on:

  25. There is a lack of consensus among physicians working in the field of disability assessment about the definition of a limited life expectancy. The aim of this study was to describe the mortality rate of employ...

    Authors: Jetske A. Kraan, Michiel A. Greidanus, Sietske J. Tamminga and Jan L. Hoving
    Citation: BMC Cancer 2025 25:531
    Content type: Research Published on:

  26. Tenosynovial giant cell tumour (TGCT) is one of the most prevalent soft tissue tumours of the foot and ankle. Although typically benign, it can exhibit locally aggressive behaviour. This study aims to evaluate...

    Authors: Christian Scheele, Norbert Harrasser, Simone Beischl, Dietmar Dammerer, Ulrich Lenze, Carolin Knebel, Rüdiger von Eisenhart-Rothe and Florian Lenze
    Citation: BMC Cancer 2025 25:530
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2025 25:627

  27. To evaluate the efficacy and safety of track sealing using subpleural injection of gelatin sponge particles in reducing the incidence of pneumothorax after percutaneous CT-guided lung biopsy.

    Authors: Zi-Yi Zhu, Ya-Qin Yun, Hao Li, Zhong-Qiang Qin, Zhen Qian, Yun Zhu, Shu-Hua Li, Bo Xie and Mu Yuan
    Citation: BMC Cancer 2025 25:529
    Content type: Research Published on:

  29. Approximately 50% of ovarian cancer (OC) survivors report fear of cancer recurrence/progression (FCR/P) as the most challenging aspect of living with cancer. This pilot, randomised waitlist-controlled trial ai...

    Authors: Verena S Wu, Allan ‘Ben’ Smith, Hayley Russell, Adeola Bamgboje-Ayodele, Lisa Beatty, Alison Pearce, Haryana Dhillon, Joanne Shaw, Jan Antony, Joanna Fardell, Anupama Pangeni, Cyril Dixon, Orlando Rincones, Laura Langdon, Daniel Costa and Afaf Girgis
    Citation: BMC Cancer 2025 25:527
    Content type: Research Published on:

  30. Image-guided superficial radiation therapy (IGSRT) using a high resolution dermal ultrasound, is becoming a non-surgical highly effective treatment option for non-melanoma skin cancer (NMSC). In a previous stu...

    Authors: Mairead Moloney, Peyton M. Harris, Peter Kaczmarski, Songzhu Zheng, Daniel Ladd, Donna Serure, Ariana Malik and Lio Yu
    Citation: BMC Cancer 2025 25:526
    Content type: Research Published on:

  31. The Xizang Autonomous Region, located in China’s southwestern frontier with an average elevation of 4000 m, faces socioeconomic development challenges influenced by its natural environment and regional dispari...

    Authors: Pingcuo Zhuoma, Gama Cangjue, Hui Wang and Jinlei Qi
    Citation: BMC Cancer 2025 25:525
    Content type: Research Published on:

  32. Salvage high-dose-rate brachytherapy (HDR-BT) is a potential treatment for localized recurrence of prostate cancer following definitive radiation therapy. This study aimed to evaluate the long-term safety and ...

    Authors: Kenta Watanabe, Nobuhiko Kamitani, Naoki Ikeda, Yujiro Kawata, Ryoji Tokiya, Takafumi Hayashi, Yoshiyuki Miyaji, Tsutomu Tamada and Kuniaki Katsui
    Citation: BMC Cancer 2025 25:524
    Content type: Research Published on:

  33. Accurately assessing the prognosis of bladder cancer patients after radical cystectomy has important clinical and research implications. Current models, based on traditional statistical approaches and complex ...

    Authors: Lei Dai, Kun Ye, Gaosheng Yao, Juan Lin, Zhiping Tan, Jinhuan Wei, Yanchang Hu, Junhang Luo, Yong Fang and Wei Chen
    Citation: BMC Cancer 2025 25:523
    Content type: Research Published on:

  34. NDRG1, a cell differentiation-associated factor, has recently emerged as a regulator ferroptosis. Nevertheless, its role in modulating ferroptosis within hepatocellular carcinoma (HCC) remains uncharacterized.

    Authors: Liuzheng Li, Tong Wu, Guocha Gong, Bo Li, Jiawei Feng, Leisheng Xu, Hairong Zhao and Xuechang Gao
    Citation: BMC Cancer 2025 25:522
    Content type: Research Published on:

  35. Olaparib exhibits antitumor effects in castration-resistant prostate cancer patients with germline mutations in DNA repair genes. We previously reported that simvastatin reduced the expression of DNA repair ge...

    Authors: Yoshitaka Sekine, Daisuke Oka, Akira Ohtsu, Hiroshi Nakayama, Takeshi Miyao, Yoshiyuki Miyazawa, Seiji Arai, Hidekazu Koike, Hiroshi Matsui, Yasuhiro Shibata and Kazuhiro Suzuki
    Citation: BMC Cancer 2025 25:521
    Content type: Research Published on:

  36. Predicting the response to neoadjuvant chemoimmunotherapy in patients with resectable non-small cell lung cancer (NSCLC) facilitates clinical treatment decisions. Our study aimed to establish a machine learnin...

    Authors: Xingbiao Liu, Zhilin Ji, Libo Zhang, Linlin Li, Wengui Xu and Qian Su
    Citation: BMC Cancer 2025 25:520
    Content type: Research Published on:

  37. Prognostic prediction plays a pivotal role in guiding personalized treatment for patients with locoregionally advanced nasopharyngeal carcinoma (LANPC). However, few studies have investigated the incremental v...

    Authors: Lian Jian, Cai Sheng, Huaping Liu, Handong Li, Pingsheng Hu, Zhaodong Ai, Xiaoping Yu and Huai Liu
    Citation: BMC Cancer 2025 25:519
    Content type: Research Published on:

  38. Gastric cancer (GC) is a prevalent malignancy affecting the digestive system. We aimed to develop a risk prediction model based on endoscopic atrophy classification for GC.

    Authors: Yadi Lan, Weijia Sun, Shen Zhong, Qianqian Xu, Yining Xue, Zhaoyu Liu, Lei Shi, Bing Han, Tianyu Zhai, Mingyue Liu, Yujing Sun and Hongwei Xu
    Citation: BMC Cancer 2025 25:518
    Content type: Research Published on:

  39. Dedifferentiated liposarcoma (DDLPS) is a fairly common subtype of soft tissue sarcoma, but relatively little is known about the clinical course and prognostic factors of this mesenchymal malignancy.

    Authors: Jelena Casier, Iris Timmermans, Annouschka Laenen, Daphne Hompes, Thomas Douchy, Raf Sciot, Melissa Christiaens, Hazem Wafa and Patrick Schöffski
    Citation: BMC Cancer 2025 25:517
    Content type: Research Published on:

  40. Multiple primary malignancies (MPM) are two or more independent primary malignancies. Recently, the relationship between microbiome and various tumors has been gradually focused on.

    Authors: Yinhang Wu, Zhanbo Qu, Zheng Wu, Jing Zhuang, Yingchen Wang, Zefeng Wang, Jian Chu, Quan Qi and Shuwen Han
    Citation: BMC Cancer 2025 25:516
    Content type: Research Published on:

  41. Ovarian cancer is the most lethal and third leading cause of gynaecological cancers globally and in South Africa (SA). However, its current mortality trends have not been evaluated in most sub-Saharan African ...

    Authors: Gbenga Olorunfemi, Elena Libhaber, Oliver C. Ezechi and Eustasius Musenge
    Citation: BMC Cancer 2025 25:515
    Content type: Research Published on:

  42. Head and neck cancer (HNC) survivors experience a significant financial burden (FB) after treatment, even in Germany with a statutory health insurance. The financial toxicity of cancer can cause higher morbidi...

    Authors: Jonas Rast, Veit Zebralla, Theresa Wald, Andreas Dietz, Gunnar Wichmann and Susanne Wiegand
    Citation: BMC Cancer 2025 25:514
    Content type: Research Published on:

  43. Lung cancer, a leading cause of mortality worldwide, necessitates effective therapeutic strategies. Caragana jubata, a traditional Chinese medicinal plant, harbors Texasin, a potential anti-tumor agent. This stud...

    Authors: Liuzhao Cao, Tiantian Li, Xingxiang Xu, Mei Sun, Weiyun Teng and Miao Zhu
    Citation: BMC Cancer 2025 25:513
    Content type: Research Published on:

  44. Pancreatic ductal adenocarcinoma (PDAC) is difficult to detect early and highly aggressive, often leading to poor patient prognosis. Existing serum biomarkers like CA19-9 are limited in early diagnosis, failin...

    Authors: Yingqi Xiao, Shixin Sun, Naxin Zheng, Jing Zhao, Xiaohan Li, Jianmin Xu, Haolian Li, Chenran Du, Lijun Zeng, Juling Zhang, Xiuyun Yin, Yuan Huang, Xuemei Yang, Fang Yuan, Xingwang Jia, Boan Li…
    Citation: BMC Cancer 2025 25:512
    Content type: Research Published on:

  45. Family caregivers are essential members of the care team of someone with pancreatic cancer, supporting their physical and psychological needs. Caregivers are often unprepared for this which may cause substanti...

    Authors: Tara Anderson, Gary Mitchell, Gillian Prue, Susan McLaughlin and Lisa Graham-Wisener
    Citation: BMC Cancer 2025 25:511
    Content type: Systematic Review Published on:

  47. There is a significant unmet need in treating patients with limited-stage small-cell lung cancer (LS-SCLC). The ETER701 study showed that Benmelstobart (TQB2450, an anti-PD-L1 antibody) combined with Anlotinib...

    Authors: Xiaoli Liu, Xiaoyan Yin, Lulu Zhuang, Junxu Wen, Zhonghui Wei, Wenxing Cui, Minghao Yu, Kaikai Zhao, Lanping Liu, Lingling Kong, Liyang Jiang, Xuquan Jing, Hui Zhu, Xunqiang Wang, Xinjun Dong, Jinming Yu…
    Citation: BMC Cancer 2025 25:509
    Content type: Research Published on:

  48. The Fc fragment of IgG binding protein (FCGBP) exhibits differential expression across various tumor types. but its role in cancer progression remains underexplored. This research discovered that FCGBP is down...

    Authors: Jiefu Wang, Ziqing Gong, Jia Liu, Wenpeng Wang, Kai Liu, Yanpeng Yang, Xinran Lu and Junfeng Wang
    Citation: BMC Cancer 2025 25:507
    Content type: Research Published on:

  49. In clinical practice, lymph node status has an important impact on colon cancer (CC) management and treatment. The role of the tumor microenvironment collagen score and immunoscore in colon cancer lymph node m...

    Authors: Chenyan Long, Jiaxin Cheng, Mingyuan Feng, Botao Yan, Yiran Li, Wei Jiang, Dexin Chen and Jun Yan
    Citation: BMC Cancer 2025 25:506
    Content type: Research Published on:

  50. Kaposi sarcoma (KS) is the commonest HIV-associated malignancy. It is caused by co-infection with Kaposi sarcoma herpesvirus (KSHV), which upregulates the MAPK pathway. The aim of the SCART trial was to identi...

    Authors: Robin J. Young, Amanda Kirkham, Joshua Savage, Charlotte Gaskell, Sarah Johnson, David H. Dockrell, Mark Bower, Sarah Westwell, Christine Bowman, Michael Leahy, Penella Woll and Lucinda Billingham
    Citation: BMC Cancer 2025 25:505
    Content type: Research Published on:

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