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  1. Patient-derived xenografts and organoids were the most common patient-derived tumor models in vitro that were utilized in personalized drug screening, and the establishment rate and duration required to be imp...

    Authors: Sheng Xu, Shen-Yi Yin, Zhi-Xin Bie, Yuan-Ming Li, Jing Qi, Yi-Dan Ma, Zheng Wang, Jianzhong Jeff Xi and Xiao-Guang Li
    Citation: BMC Cancer 2025 25:649
    Content type: Research Published on:

  2. Subsolid nodules emerged as frequent radiological variants of lung adenocarcinoma. Radiological features including solid-component prevalence and larger tumour dimensions prompt tumoral invasiveness guiding pr...

    Authors: Riccardo Tajè, Filippo Tommaso Gallina, Mauro Caterino, Daniele Forcella, Alexandro Patirelis, Gabriele Alessandrini, Simonetta Buglioni, Fabiana Letizia Cecere, Francesca Fusco, Federico Cappelli, Enrico Melis, Paolo Visca, Federico Cappuzzo, Vincenzo Ambrogi and Antonello Vidiri
    Citation: BMC Cancer 2025 25:647
    Content type: Research Published on:

  4. Prostate cancer is the most common cancer in men aged above 75 years old. Given their heterogeneity, the International Society of Geriatric Oncology recommends using a comprehensive geriatric assessment (CGA) ...

    Authors: Maëva Bonneau, Zara Steinmeyer, Mathilde Morisseau, Stéphanie Lozano, Patricia Barbe, Catherine Chauvet, Delphine Brechemier, Loïc Mourey and Laurent Balardy
    Citation: BMC Cancer 2025 25:642
    Content type: Research Published on:

  5. Non-small-cell lung cancer (NSCLC) is one of the most common malignant tumors, with poor prognosis and increasing osimertinib therapy resistance. Revealing mechanisms of NSCLC progression and therapy resistanc...

    Authors: Hongyang Sang, Jinlong Liu, Xifang Chen and Yingou Zeng
    Citation: BMC Cancer 2025 25:641
    Content type: Research Published on:

  6. The reliability of the M.D. Anderson Symptom Inventory-Multiple Myeloma Module (MDASI-MM) was evaluated through its Chinese translation among Chinese patients with multiple myeloma.

    Authors: Ting Wang, Weiwei Chen, Yingying Lin, LeiWen Tang, Junxiang Sun, Yao Ge, Yanke Mao and Huan Liu
    Citation: BMC Cancer 2025 25:640
    Content type: Research Published on:

  7. The purpose of the study was to evaluate the dosimetric characteristics of volumetric modulated arc therapy (VMAT), helical tomotherapy (HT), and intensity-modulated proton therapy (IMPT) and to compare the do...

    Authors: Xiaoyan Yin, Xiutong Lin, Guifang Zhang, Yong Yin and Tao Sun
    Citation: BMC Cancer 2025 25:639
    Content type: Research Published on:

  8. This study aimed to evaluate the effectiveness of different tracers´ application techniques for sentinel lymph node (SLN) detection in women with endometrial cancer undergoing laparotomy. Additionally, potenti...

    Authors: Borek Sehnal, Petr Waldauf, Radoslav Matej, Martin Hruda, Helena Robova, Jana Drozenova, Tomas Pichlik, Jan Zapletal, Lukas Rob and Michael J. Halaska
    Citation: BMC Cancer 2025 25:638
    Content type: Research Published on:

  9. Sepsis remains a leading cause of mortality in critically ill patients, particularly those with malignancies who face heightened risks due to immunosuppression and metabolic dysregulation. This study aimed to ...

    Authors: Yongshi Shen, Kangni Lin, Liuxin Yang, Peng Zheng, Wei Zhang, Jinsen Weng and Yong Ye
    Citation: BMC Cancer 2025 25:637
    Content type: Research Published on:

  10. Neoadjuvant chemotherapy with docetaxel, cisplatin plus 5-FU (DCF) has become the new standard of care for locally advanced esophageal squamous cell carcinoma (ESCC). In a real-world setting, the efficacy, rec...

    Authors: Mikako Tamba, Hiroki Osumi, Mariko Ogura, Shota Fukuoka, Akihiko Okamura, Jun Kanamori, Yu Imamura, Koichiro Yoshino, Shohei Udagawa, Takeru Wakatsuki, Eiji Shinozaki, Masayuki Watanabe, Kensei Yamaguchi, Keisho Chin and Akira Ooki
    Citation: BMC Cancer 2025 25:636
    Content type: Research Published on:

  11. Chronic hepatitis B (CHB) patients who have sustained virological suppression (SVS) still develop hepatocellular carcinoma(HCC), and the risk factors for developing HCC in these patients are not fully understo...

    Authors: Jianna Zhang, Zhiqiang Lan, Kailu Zhu, Sijie Yu, Shibo Li and Yu Huang
    Citation: BMC Cancer 2025 25:635
    Content type: Research Published on:

  12. This study aimed to evaluate the prognostic significance of lactate dehydrogenase (LDH) and fasting triglyceride-glucose (TyG) index in advanced hormone-sensitive prostate cancer (HSPC) patients, with the ulti...

    Authors: Xiaolong Xu, Weiyu Fei, Mingshuang Wu, Yi He, Bo Yang and Cuicui Lv
    Citation: BMC Cancer 2025 25:634
    Content type: Research Published on:

  13. The standard treatment for localized/locally advanced gastroesophageal adenocarcinoma (GEA) is radical surgery and peri-operative FLOT treatment (5-fluorouracil plus leucovorin, oxaliplatin, and docetaxel), bu...

    Authors: Vincenzo Nasca, Francesca Bergamo, Luisa Foltran, Lorenzo Antonuzzo, Katia Bencardino, Emanuela Dell’Aquila, Salvatore Corallo, Andrea Spallanzani, Oronzo Brunetti, Daniele Spada, Stefano Tamberi, Chiara Alessandra Cella, Antonio Avallone, Lorenzo Fornaro, Samantha Di Donato, Antonia Strippoli…
    Citation: BMC Cancer 2025 25:633
    Content type: Study Protocol Published on:

  14. This study aimed to explore the association between Life’s Essential 8 (LE8) and the risk of cancer occurrence and cancer-associated mortality across 24 cancer types. The cardiovascular health (CVH) score is c...

    Authors: Chuang Yang, Wenke Cheng, Patrick S. Plum, Florian Lordick, Jeanette Köppe, Ines Gockel and René Thieme
    Citation: BMC Cancer 2025 25:632
    Content type: Research Published on:

  15. The association between microRNA 17–92 cluster host gene (MIR17HG) polymorphisms and the risk of cancer has been evaluated in studies, here, we attempted to elucidate the relationship between 6 single nucleotide ...

    Authors: Binghua Tong, Zhaonan Zhang, Zhaowei Xu and Yangyang Yang
    Citation: BMC Cancer 2025 25:631
    Content type: Research Published on:

  16. Melanoma (SKCM) is an extremely aggressive form of cancer, characterized by high mortality rates, frequent metastasis, and limited treatment options. Our study aims to identify key target genes and enhance the...

    Authors: Songyun Zhao, Zihao Li, Kaibo Liu, Gaoyi Wang, Quanqiang Wang, Hua Yu, Wanying Chen, Hao Dai, Yijun Li, Jiaheng Xie, Yucang He and Liqun Li
    Citation: BMC Cancer 2025 25:630
    Content type: Research Published on:

  17. Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the oral and maxillofacial regions. Paeonol, derived from Moutan Cortex, has diverse pharmacological effects including anti-inflammatory a...

    Authors: Kang Yang, Baosen Yue, Huan Tian, Lu Wang, Xiao Yang and Weiying Zhang
    Citation: BMC Cancer 2025 25:629
    Content type: Research Published on:

  18. This study aimed to explore and compare the genomic characteristics and pathogenicity of Helicobacter pylori (H. pylori) strains derived from the gastric cancer (GC) and gastritis in the Chinese population.

    Authors: Peng-fei Kong, Yong-hao Yan, Yan-tao Duan, Yan-tian Fang, Yi Dou, Yong-hu Xu and Da-zhi Xu
    Citation: BMC Cancer 2025 25:628
    Content type: Research Published on:

  20. Areca nut (AN) was classified as a carcinogen by the International Agency for Research on Cancer (IARC) of the WHO in 2003. AN has the same carcinogenic components as cigarettes, such as benzo[a]pyrene (B[a]P)...

    Authors: Yixuan Li, Jing Zhou, Lirong Liu, Chaoyong Zhu, Ziyue Luo, Na Li, Pengfei Lyu, Jing Zhang, Tian Xie, Yipeng Ding and Sha Xiao
    Citation: BMC Cancer 2025 25:626
    Content type: Research Published on:

  22. This study aimed to learn the sketch of HPV infection and cervical lesions including squamous intraepithelial lesions (SIL) and cervical cancer in the population of patients with pelvic organ prolapse and to a...

    Authors: Yanjun Ge, Fan Wu, Yuchen Zhang, Xintao Wang and Guizhu Wu
    Citation: BMC Cancer 2025 25:624
    Content type: Research Published on:

  23. Gamma-delta (γδ) T cells are a critical component of the tumor microenvironment and have been recognized as a promising biomarker and target for cancer therapy. Increasing evidence suggests that γδT cells play...

    Authors: Guixin Wang, Shuo Wang, Wenbin Song, Chenglu Lu, Zhaohui Chen, Long He, Xiaoning Wang, Yizeng Wang, Cangchang Shi, Zhaoyi Liu, Yue Yu, Xin Wang, Yao Tian and Yingxi Li
    Citation: BMC Cancer 2025 25:623
    Content type: Research Published on:

  24. The effect of diffusion-weighted magnetic resonance imaging (DWI)-guided dose-painting intensity-modulated radiation therapy (DP-IMRT) on locally advanced recurrent nasopharyngeal carcinoma (NPC) remains uncle...

    Authors: Chao Tan, Yuyi Li, Xiaoyu Chen, Weichang Zhu, Cuihong Jiang, Lili He, Shuai Xiao, Changgen Fan, Xu Ye, Qi Zhao, Wenqiong Wu, Yanxian Li, Yanfang Qiu, Kailin Chen, Shulu Hu, Feng Liu…
    Citation: BMC Cancer 2025 25:622
    Content type: Research Published on:

  25. Cancer causes stress that impairs overall health of clients, their family members and health providers regardless of its stage. Despite the presence of various types of coping strategies to improve quality of ...

    Authors: Berhan Tsegaye Negash and Yitateku Alelign
    Citation: BMC Cancer 2025 25:621
    Content type: Research Published on:

  26. Malignant melanoma (MM) is a highly aggressive skin tumor with a rising incidence and poor prognosis. Although current clinical treatments, including surgery, targeted therapy, immunotherapy, and radiotherapy,...

    Authors: Wumei Zhao, Ziwen Chen, Wenxing Fu, Chenyan Ye, Haijing Fu, Tianyi Xu, Binghui Wu, Lina Chen and Shi-Jun Shan
    Citation: BMC Cancer 2025 25:620
    Content type: Research Published on:

  27. Immune checkpoint inhibitor (ICI) have been utilized in bone and soft tissues sarcoma patients under multiple circumstances in combination with surgeries and chemotherapy. Regretfully, immune-related adverse e...

    Authors: Qing Zhang, Zhe Wang, Xueqin Zeng, Yi Ding and Chen Wang
    Citation: BMC Cancer 2025 25:619
    Content type: Research Published on:

  29. Ubiquitin-specific protease 35 (USP35) has gained attention as a regulator in cancer progression. However, its specific role in kidney clear cell carcinoma (KIRC) remains unclear.

    Authors: Yadong Guo, Ziyou Lin, Zijing Zhou, Wentao Zhang, Shiyu Mao, Zezhi Shan, Pengfei Wu and Xudong Yao
    Citation: BMC Cancer 2025 25:617
    Content type: Research Published on:

  30. To investigate the prognostic value of the apparent diffusion coefficient (ADC) calculated from diffusion-weighted imaging (DWI) to cytoreductive surgery (CRS), with or without hyperthermic intraperitoneal che...

    Authors: Xin Xin, Yongfang Tang, Man Lu, Jie Huang, Jian Shang, Lidan Yang, Lihuan Dai, Jinxue Yin, Jiansheng Li, Qibin Leng, Hongsheng Tang and Xi Zhong
    Citation: BMC Cancer 2025 25:616
    Content type: Research Published on:

  31. We aimed to investigate the diagnostic performance of biparametric MRI (bpMRI)-based radiomics in differentiating clinically significant prostate cancer (csPCa) among lesions categorized as Prostate Imaging Re...

    Authors: Feng Lu, Yanjun Zhao, Zhongjuan Wang and Ninghan Feng
    Citation: BMC Cancer 2025 25:615
    Content type: Research Published on:

  32. Managing advanced cancer can be psychologically distressing and burdensome for family caregivers and their care recipients. Innovations in the collection and modelling of passive data from personally-owned sma...

    Authors: J. Nicholas Odom, Kyungmi Lee, Erin R. Harrell, Kristen Allen Watts, Avery C. Bechthold, Sally Engler, Frank Puga, Natashia Bibriescas, Arif H. Kamal, Christine S. Ritchie, George Demiris, Alexi A. Wright, Marie A. Bakitas and Andres Azuero
    Citation: BMC Cancer 2025 25:614
    Content type: Research Published on:

  33. Everolimus is the only approved therapy for patients with advanced neuroendocrine tumors (NET) of lung and thymus and new treatment options are urgently needed. Expression of somatostatin receptor 2 (SSTR2) is...

    Authors: Jaume Capdevila, Virginia Pubul, Urbano Anido, Thomas Walter, Javier Molina-Cerrillo, Teresa Alonso-Gordoa, Rocio Garcia-Carbonero, Maria San-Roman-Gil, Belen Llana, Paula Jimenez-Fonseca, Marta Benavent Viñuales, Catherine Ansquer, Eric Baudin, Come Lepage, Maribel del Olmo-García, José Carlos Ruffinelli…
    Citation: BMC Cancer 2025 25:613
    Content type: Study Protocol Published on:

  34. Morocco’s national breast cancer screening program (NBCSP) was launched in 2010 in response to rising breast cancer incidence. The program comprises clinical breast examination (CBE) and diagnostic mammography...

    Authors: Melissa M. Carvalho, Aissatou Bah, Sofia Azrib, Robert A. Hiatt, Saber Boutayeb, Lahcen Belyamani, Amr S. Soliman and Mohamed Khalis
    Citation: BMC Cancer 2025 25:612
    Content type: Research Published on:

  35. Oral squamous cell carcinoma is a malignant tumor with high morbidity and mortality, and changes in microflora have a close relationship with tumor development. In this study, we tried to identify the changes ...

    Authors: Kaitong Wei, Yaqing Ma, Jing Xu, Hongyu Zheng, Lianping Xue, Yaojuan Chu, Yingying Shi, Zhi Sun and Qiang Sun
    Citation: BMC Cancer 2025 25:611
    Content type: Research Published on:

  36. The high occurrence of treatment resistance in patients with hormone receptor-positive (HR +) breast cancer is a global health concern. Thus, effective immunotherapy must be developed. The public neoantigens, ...

    Authors: Yukari Ando, Hiroko Miyadera, Hiroko Bando, Sachie Hashimoto, Emiko Noguchi and Hisato Hara
    Citation: BMC Cancer 2025 25:610
    Content type: Research Published on:

  37. The tumor microenvironment of breast cancer encompasses a broad spectrum of immune cell populations. These cell populations are biologically/clinically relevant to varying degrees. The causal relationship betw...

    Authors: Zhixuan Wu, Rongrong Zhang, Xue Wu, Xinyu Meng, Haodong Wu, Xiaowu Wang, Danni Zheng and Yanyan Shen
    Citation: BMC Cancer 2025 25:609
    Content type: Research Published on:

  38. Skull base chordoma is a rare and aggressive bone tumor with a poor prognosis. The basement membrane (BM) plays an pivotal role in tumor progression. However, the involvement of BM-related genes in assessing t...

    Authors: Tianhao Zhang, Mingxuan Li, Xing Liu, Sida Zhao, Tianshun Ma, Yide Liu, Xijia Zhang, Qian Liu, Jiwei Bai and Yazhuo Zhang
    Citation: BMC Cancer 2025 25:608
    Content type: Research Published on:

  39. Cervical cancer is a significant global health issue affecting women worldwide, necessitating prompt detection and effective management. According to the World Health Organization (WHO), approximately 660,000 ...

    Authors: Zahra Taghados, Zohreh Azimifar, Malihezaman Monsefi and Mojgan Akbarzadeh Jahromi
    Citation: BMC Cancer 2025 25:607
    Content type: Research Published on:

  40. There is a low incidence of gastric neuroendocrine carcinoma (G-NEC), but it is associated with particularly aggressive biological behaviours and poor prognosis compared with other gastric neoplasms. Our study...

    Authors: Kai Zhou, Xiao Hu, Xuesong Yang, Yan Wu, Ke Ji, Xin Ji, Ji Zhang, Xiaojiang Wu, ZhongWu Li, Anqiang Wang, Yusheng Wang and Zhaode Bu
    Citation: BMC Cancer 2025 25:606
    Content type: Research Published on:

  41. Minimally invasive thermal therapies show great prospect in non-small cell lung cancer (NSCLC) treatment. However, changes in immune cell populations following microwave ablation (MWA) in NSCLC microenvironmen...

    Authors: Run-Qi Guo, Yuan-Ming Li, Zhi-Xin Bie, Jin-Zhao Peng and Xiao-Guang Li
    Citation: BMC Cancer 2025 25:605
    Content type: Research Published on:

  43. This study aimed to evaluate the predictive efficacy of the prognostic nutritional index (PNI) in patients with intermediate and advanced hepatocellular carcinoma (HCC) treated with a regimen consisting of hep...

    Authors: Hao-Huan Tang, Ming-Qing Zhang, Zi-Chen Zhang, Chen Fan, Shu-Shu Li, Wei Chen and Wei-Dong Wang
    Citation: BMC Cancer 2025 25:603
    Content type: Research Published on:

  44. Identifying effective predictive strategies to assess the response of immune checkpoint inhibitors (ICIs)-based combination therapy in advanced hepatocellular carcinoma (HCC) is crucial. This study presents a ...

    Authors: Jun Xu, Junjun Li, Tengfei Wang, Xin Luo, Zhangxiang Zhu, Yimou Wang, Yong Wang, Zhenglin Zhang, Ruipeng Song, Li-Zhuang Yang, Hongzhi Wang, Stephen T. C. Wong and Hai Li
    Citation: BMC Cancer 2025 25:602
    Content type: Research Published on:

  45. As key mediators of antitumor immunity, CD8 + tumor-infiltrating lymphocytes present antigens and initiate robust immune responses against cancer cells. When stratified by location, CD8 + T lymphocytes were co...

    Authors: Ruijie Niu, Cheng Wang, Yiqun Xie, Shuangshuang Li, Qian Zhao, Yuqing Chang and Zubing Mei
    Citation: BMC Cancer 2025 25:601
    Content type: Research Published on:

  47. Culturally and linguistically diverse (CaLD) consumers and carers have been identified as experiencing high levels of unmet needs relating to information and support across the cancer journey. This review iden...

    Authors: Lisa Whitehead, Deborah Kirk, Pelden Chejor, Weiting Liu, Minh Nguyen, Caroline Balczer, Charlene Lan and Melissa Evans
    Citation: BMC Cancer 2025 25:599
    Content type: Systematic Review Published on:

  48. The Node Reporting and Data System (Node-RADS) offers a reliable framework for lymph node assessment, but its prognostic significance remains unexplored. This study aims to investigate the added prognostic val...

    Authors: Yan Sun, Lu Wen, Wang Xiang, Xiangtong Luo, Lian Chen, Xiaohuang Yang, Yanhui Yang, Yi Zhang, Sanqiang Yu, Hua Xiao and Xiaoping Yu
    Citation: BMC Cancer 2025 25:598
    Content type: Research Published on:

  49. Follow-up is essential especially for patients who are at a high risk of recurrence after radical resection of hepatocellular carcinoma (HCC). The aim of this study was to develop a predictive model aimed at i...

    Authors: Zichen Yu, Wenli Cao, Chengfei Du, Jie Liu, Liping Peng and Fangqiang Wei
    Citation: BMC Cancer 2025 25:597
    Content type: Research Published on:

  50. To establish prediction models to predict 2-year overall survival (OS) and stratify patients with different risks based on radiomics features extracted from magnetic resonance imaging (MRI) and computed tomogr...

    Authors: Nuo Yu, Yidong Wan, Lijing Zuo, Ying Cao, Dong Qu, Wenyang Liu, Lei Deng, Tao Zhang, Wenqing Wang, Jianyang Wang, Jima Lv, Zefen Xiao, Qinfu Feng, Zongmei Zhou, Nan Bi, Tianye Niu…
    Citation: BMC Cancer 2025 25:596
    Content type: Research Published on:

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