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  1. Interstitial pneumonitis is a potentially fatal complication of cancer-related therapy. However, data regarding the risk factors, prognosis and safety and benefit of rechallenge treatment are scarce.

    Authors: Hung-Yuan Yu, Chun-Yang Lee, Yen-Chi Hu, Le-Gin Lin, Yee Chao and Chung-Pin Li
    Citation: BMC Cancer 2025 25:508
    Content type: Research Published on:

  2. This study assessed the global cancer burden due to occupational carcinogens (OCs) using data from Global Burden of Disease (GBD) 2021. Mortality and disability-adjusted life years (DALYs) were employed to ass...

    Authors: Binbin Zou, Ping Wu, Jianjun Chen, Juan Luo, Yanjun Lei, Qingqing Luo, Biqiong Zhu and Ming Zhou
    Citation: BMC Cancer 2025 25:503
    Content type: Research Published on:

  3. This study was conducted to evaluate the prognosis of cervical cancer in pregnancy (CCIP) and analyze the clinicopathological factors affecting the prognosis of this cancer.

    Authors: Siyuan Zeng, Xin Li, Simin Xiao, Peina Yang, Changsheng Lin, Huiling Chen, Hu Zhao and Xue Xiao
    Citation: BMC Cancer 2025 25:502
    Content type: Systematic Review Published on:

  5. Bromodomain and extra-terminal domain (BET) inhibitors (BETi) have demonstrated epigenetic modulation capabilities, specifically in transcriptional repression of oncogenic pathways. Preclinical assays suggest ...

    Authors: Daniel Marbach, Jurriaan Brouer-Visser, Laura Brennan, Sabine Wilson, Iakov I. Davydov, Nicolas Staedler, José Duarte, Iris Martinez Quetglas, Eveline Nüesch, Marta Cañamero, Evelyne Chesné, George Au-Yeung, Erika Hamilton, Stephanie Lheureux, Debra L. Richardson, Iben Spanggaard…
    Citation: BMC Cancer 2025 25:500
    Content type: Research Published on:

  6. Hyperleukocytic acute myeloid leukemia (HLL) is marked by high early mortality and presents significant therapeutic challenges. Research on HLL is still in its infancy, and comprehensive development of patient...

    Authors: Yanxia Jin, Yuxing Liang, Balu Wu, Sanyun Wu, Xiaoyan Liu and Fuling Zhou
    Citation: BMC Cancer 2025 25:499
    Content type: Research Published on:

  7. In recent years, immunotherapy has made significant progress. However, the understanding of the heterogeneity and function of T cells, particularly CD8 + T cells, in cervical cancer (CESC) microenvironment rem...

    Authors: Rongbin Zhou, Yuli Xie, Zuheng Wang, Zige Liu, Wenhao Lu, Xiao Li, Chunmeng Wei, Xing Li and Fubo Wang
    Citation: BMC Cancer 2025 25:498
    Content type: Research Published on:

  8. The potential of medical imaging to non-invasively assess intratumoral heterogeneity (ITH) is increasingly being recognized. This study aimed to investigate the value of the ITH-based deep learning model for p...

    Authors: Shaoming Song, Gong Zhang, Zhiyuan Yao, Ruiqiu Chen, Kai Liu, Tianchen Zhang, Guineng Zeng, Zizheng Wang and Rong Liu
    Citation: BMC Cancer 2025 25:497
    Content type: Research Published on:

  9. The current understanding of the prognostic value of routine pre-treatment laboratory parameters in patients with high-risk soft tissue sarcoma (HR-STS) is limited. We sought to analyze several inflammatory bi...

    Authors: Luc M. Berclaz, Dorit Di Gioia, Vindi Jurinovic, Michael Völkl, Sinan E. Güler, Markus Albertsmeier, Alexander Klein, Hans Roland Dürr, Sina Mansoorian, Thomas Knösel, Wolfgang G. Kunz, Michael von Bergwelt-Baildon, Lars H. Lindner and Anton Burkhard-Meier
    Citation: BMC Cancer 2025 25:496
    Content type: Research Published on:

  10. The cytological diagnostic process of EUS-FNA smears is time-consuming and manpower-intensive, and the conclusion could be subjective and controversial. Moreover, the relative lack of cytopathologists has limi...

    Authors: Dong Fang, Yigeng Huang, Suwen Li, Chen Shi, Junjun Bao, Dandan Du, Lanlan Xuan, Leping Ye, Yanping Zhang, ChengLin Zhu, Hailun Zheng, Zhenwang Shi, Qiao Mei and Huanqin Wang
    Citation: BMC Cancer 2025 25:495
    Content type: Research Published on:

  11. Wilms tumor, a prevalent pediatric kidney cancer, has been extensively studied to elucidate its genetic mechanisms. NAT10 (N-acetyltransferase 10) is a gene encoding acetyltransferase, which is involved in variou...

    Authors: Changmi Deng, Jinhong Zhu, Fei Duan, Wenli Zhang, Haixia Zhou, Suhong Li, Jiao Zhang, Jiwen Cheng, Wen Fu, Jing He, Huizhong Niu and Rui-Xi Hua
    Citation: BMC Cancer 2025 25:494
    Content type: Research Published on:

  13. Breast cancer is a significant health issue for women worldwide and poses unique challenges for all ages. Older women face many concerns about breast cancer treatment and outcomes. This study aims to compare b...

    Authors: Serena Bertozzi, Ambrogio P. Londero, Jose Andres Diaz Nanez, Roberta Di Vora, Barbara Baita, Lucia La Verghetta, Serena Prada, Luca Seriau, Laura Mariuzzi and Carla Cedolini
    Citation: BMC Cancer 2025 25:492
    Content type: Research Published on:

  14. Perineural Invasion (PNI) is a marker of a highly invasive tumor with poor prognosis, but the real influence on the prognosis of cervical cancer is still debated. We aimed to systematically investigate the pro...

    Authors: Guangyao Cai, Siru Zhang, Shangbin Gao, Ting Deng, He Huang, Yanling Feng and Ting Wan
    Citation: BMC Cancer 2025 25:491
    Content type: Systematic Review Published on:

  15. Chemotherapy-induced neutropenia (CIN) is usually managed by recombinant human granulocyte colony stimulating factor (rhG-CSF) and pegylated rhG-CSF (PEG-rhG-CSF). This study evaluated the efficacy and safety ...

    Authors: Yuankai Shi, Xinshuai Wang, Zhidong Pei, Huaqiu Shi, Yanjun Zhang, Tienan Yi, Jiazhuan Mei, Yanzhen Guo, Youhong Dong, Tianjiang Ma, Qingyuan Zhang, Xiaojing Jia, Zhengqiu Zhu, Shen Xu, Yanyan Liu, Hongrui Niu…
    Citation: BMC Cancer 2025 25:490
    Content type: Research Published on:

  16. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Tumor treating fields (TTFields) combined with anti-PD immunotherapy offers a promising strategy to address this issue. Nevertheless, ...

    Authors: Wei Lin, Yingying Wang, Minghao Li, Jingjing Feng, Ying Yue, Jing Yu, Yanjiang Hu and Yuanzhen Suo
    Citation: BMC Cancer 2025 25:489
    Content type: Research Published on:

  17. Although the association between excess weight and cancer risk is well established, it is not known how this association evolves across the lifespan. We aimed to investigate the strength of the association of ...

    Authors: Marko Mandic, Fatemeh Safizadeh, Ben Schöttker, Bernd Holleczek, Michael Hoffmeister and Hermann Brenner
    Citation: BMC Cancer 2025 25:488
    Content type: Research Published on:

  20. In nasopharyngeal carcinoma (NPC) patients, two radiation target delineation patterns are used for the cervical lymph node area.

    Authors: Lin Wang, Hui-Min Wang, Fan Tang, Yan-Ting Zhang, Rong-Rong Shi, Sheng-Hui Wang, Si-Chao Liang, Liao-Ming Gao, Zhi-Ting Chen, Bao-Feng Li and Bei Chen
    Citation: BMC Cancer 2025 25:485
    Content type: Research Published on:

  21. Anastomotic leak (AL) is a common complication in patients with operable esophageal squamous cell carcinoma (ESCC) treated with neoadjuvant chemoradiotherapy (NCRT) and radical esophagectomy. Therefore, this s...

    Authors: Junfeng Zhao, Guanli Yang, Ying Li, Shanshan Li, Haining Luo, Dan Han, Baosheng Li and Qiang Cao
    Citation: BMC Cancer 2025 25:484
    Content type: Research Published on:

  22. To evaluate the acceptability of a risk-based breast cancer screening (BCS) strategy among professionals involved in MyPeBS study in 6 countries.

    Authors: Alexandra Roux, Lucile Hervouet, Francesca Di Stefano, David P. French, Livia Giordano, David Ritchie, Marie-Eve Rougé Bugat, Debbie Keatley, Rachel Cholerton, Lorna McWilliams, Paolo Giorgi Rossi, Corinne Balleyguier, Michal Guindy, Fiona J. Gilbert, Jean-Benoit Burrion, Marta Roman…
    Citation: BMC Cancer 2025 25:483
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2025 25:687

  23. Transposable elements (TEs), which constitute nearly half of the human genome, have long been regarded as genomic "dark matter". However, their reactivation in tumor cells, resulting in the production of TE-ch...

    Authors: Yang Li, Yahui Liu, Yingxin Xie, Yaxuan Wang, Jing Wang, Huan Wang, Lin Xia and Dan Xie
    Citation: BMC Cancer 2025 25:482
    Content type: Research Published on:

  24. Identifying the past and future burden of kidney cancer (KC) and its temporal trends among older adults (≥ 65 years) at global, regional, and national levels is critical for effective prevention strategies.

    Authors: Nan Zhou, Hongjing Bai, Ziyan Zhang, Baofeng Yu, Hong Zhao, Jinbo Li and Guoping Zheng
    Citation: BMC Cancer 2025 25:481
    Content type: Research Published on:

  26. Cytoreductive Surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are techniques developed for curative treatment of peritoneal carcinomatosis (PC). Studies have shown that CRS + HIPEC provides...

    Authors: Burak Dinçer, Ali Fuat Kaan Gök, Mehmet İlhan, Leman Damla Ercan, Cemil Burak Kulle, Celal Caner Ercan, Neslihan Berker and Cemalettin Ertekin
    Citation: BMC Cancer 2025 25:479
    Content type: Research Published on:

  27. Lung cancer remains a leading cause of cancer-related mortality, primarily because of the lack of effective diagnostic and therapeutic biomarkers. To address the issue of fragmented biomarker data across numer...

    Authors: Yinghong Li, Zhuohao Tong, Yinqi Yang, Yu Wang, Lu Wen, Yuke Li, Mingze Bai, Yongfang Xie, Bo Li and Kunxian Shu
    Citation: BMC Cancer 2025 25:478
    Content type: Research Published on:

  28. The COVID-19 pandemic exerted unprecedented pressure on healthcare systems worldwide, leading governments and hospitals to postpone elective procedures to prioritize care for COVID-19 patients. Cancer patients...

    Authors: Loïc Brunner, Anna Nicolet, Isabelle Peytremann-Bridevaux, Joachim Marti, Jean-Luc Bulliard, Lorenzo Righi, Christian Britschgi, Andreas Wicki, Christine Bienvenu, Ursula Ganz-Blaettler, Manuela Eicher, Olivier Michielin, Karine Moschetti and Marie-Annick Le Pogam
    Citation: BMC Cancer 2025 25:477
    Content type: Research Published on:

  29. Conventional epidemiological studies have reported inconsistent results regarding the potential adverse effects of long-term use of antihypertensive drugs on cancer risk. Nevertheless, evidence of their impact...

    Authors: Zehui Yao, Dailei Qin, Jianzhong Cao, Chun Gao, Pu Xi, Shengping Li and Ran Wei
    Citation: BMC Cancer 2025 25:476
    Content type: Research Published on:

  31. The combination of radiation with immune checkpoint inhibitors (ICIs) has been demonstrated to display synergistic effects in solid cancers. Nevertheless, the anti-tumor effect of combining radiation with prog...

    Authors: Zihao Yin, Hongfang Zhang, Ke Zhang, Jing Yue, Rongjun Tang, Yaping Wang, Qinghua Deng and Qingqing Yu
    Citation: BMC Cancer 2025 25:474
    Content type: Research Published on:

  32. D-2-hydroxyglutarate (D-2-HG) is an oncometabolite that accumulates due to mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2). D-2-HG may be used as a surrogate marker for IDH1/2 mutant cancers, yet simple an...

    Authors: Kristian A. Choate, Wren W. L. Konickson, Zoe L. Moreno, Olivia S. Brill, Brett C. Cromell, Bella M. Detienne, Matthew J. Jennings, Paul B. Mann, Robert J. Winn, David O. Kamson and Evan P.S. Pratt
    Citation: BMC Cancer 2025 25:473
    Content type: Research Published on:

  33. Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) represents an uncommon variant of primary liver cancer. In recent years, its incidence rate has increased. Thus, it is essential to perform comprehensive i...

    Authors: Huan Tang, Changpeng Chai, Xin Miao, Yuanhui Su, Cheng Yu, Jianfeng Yi, Zhengfeng Wang, Hui Zhang, Zhenjie Zhao, Linpei Wang, Wence Zhou and Hao Xu
    Citation: BMC Cancer 2025 25:472
    Content type: Research Published on:

  34. Unmet supportive care needs reducing the quality of life of colorectal cancer (CRC) patients. As existing studies have indicated the supportive care needs of CRC patients of different genders differ, the main ...

    Authors: Jiyin Zhang, Bei Dong, Haiyan Dong, Daoxia Guo, Yang Yuan and Li Tian
    Citation: BMC Cancer 2025 25:471
    Content type: Research Published on:

  35. Neuroblastoma (NB), a common infantile neuroendocrine tumor, presents a substantial therapeutic challenge when MYCN is amplified. Given that the protein structure of N-Myc is disordered, we utilized Alphafold ...

    Authors: Hongli Yin, Tianyi Liu, Di Wu, Xiaolu Li, Gen Li, Weiwei Song, Xiaodong Wang, Shan Xin, Yisu Liu and Jian Pan
    Citation: BMC Cancer 2025 25:470
    Content type: Research Published on:

  36. To evaluate the safety and efficacy of ultrasound (US)-guided microwave ablation (MWA) for inactivating excess remnant thyroid (RT) after surgery in patients with differentiated thyroid cancer (DTC).

    Authors: Yihao Chen, Rongwei Hu, Chunchun Jin, Leidan Huang, Yiqin Lin, Bingzi Zou, Xiaorui Liu, Zhilin Li, Zhengyi Li and Weizong Liu
    Citation: BMC Cancer 2025 25:469
    Content type: Research Published on:

  37. Bladder cancer (BCa) is a common urinary malignancy with high recurrence rates in non-muscle invasive bladder cancer (NMIBC), posing significant clinical challenges. Emerging evidence links urinary microbiota ...

    Authors: Zhaoyang Sheng, Jinshan Xu, Maoyu Wang, Xi Xu, Jinpeng Zhu, Shuxiong Zeng, Chuanliang Xu and Zhensheng Zhang
    Citation: BMC Cancer 2025 25:468
    Content type: Research Published on:

  38. Immunotherapy combined with chemotherapy has shown good results in the treatment of extensive-stage small cell lung cancer (ES-SCLC), but there are fewer clinical studies on elderly ES-SCLC patients. This stud...

    Authors: Ke Zhao, Shuangqing Lu, Jiling Niu, Hui Zhu, Yaru Tian and Jinming Yu
    Citation: BMC Cancer 2025 25:467
    Content type: Research Published on:

  39. Mitochondrial-encoded circular RNAs (mecciRNAs) are a newly discovered class of mitochondrial-encoded non-coding RNAs (mt-ncRNAs) that play important biological roles in the cell. This study aimed to examine t...

    Authors: Seyed Taha Nourbakhsh, Seyed Abbas Mirzaei, Fatemeh Mohamadhashem, Mohammad Mehdi Naghizadeh, Amir Nader Razavi, Yaser Mansoori, Abdolreza Daraei and Faezeh Mohamadhashem
    Citation: BMC Cancer 2025 25:466
    Content type: Research Published on:

  40. To investigate associations between breast cancer molecular subtype and intravoxel incoherent motion imaging (IVIM) and amide proton transfer-weighted (APTw).

    Authors: Nan Zhang, Xiali Shao, Lianyan Xu, Wei Zhu, Haiyu Wang, Rongkui Luo, Chun Yang, Xiaodan Ye, Mengsu Zeng, Caizhong Chen, Xiuzheng Yue, Zhenghong Bi and Xin Lu
    Citation: BMC Cancer 2025 25:465
    Content type: Research Published on:

  41. To clarify the long-term prognoses of elderly upper tract urothelial carcinoma (UTUC) patients after surgery.

    Authors: Shuhei Suzuki, Yoshiyuki Nagumo, Kosuke Kojo, Shuya Kandori, Hiromichi Sakurai, Reo Takahashi, Bunpei Isoda, Akane Yamaguchi, Kazuki Hamada, Kozaburo Tanuma, Satoshi Nitta, Masanobu Shiga, Atsushi Ikeda, Takashi Kawahara, Akio Hoshi, Hiromitsu Negoro…
    Citation: BMC Cancer 2025 25:464
    Content type: Research Published on:

  42. Ovarian cancer (OC) stands as a formidable adversary among women, remaining a leading cause of cancer-related mortality owing to its aggressive and invasive nature. Investigating prognostic markers intricately...

    Authors: Haoyu Wang, Tian Tu, Lijun Yin, Zhenfeng Liu and Hui Lu
    Citation: BMC Cancer 2025 25:462
    Content type: Research Published on:

  43. Neoadjuvant chemotherapy (NAC) has been confirmed to improve the prognosis of patients with advanced gastric cancer (AGC). However, no study has investigated whether Helicobacter pylori (HP) infection affects the...

    Authors: Qi-Chen He, Ze-Ning Huang, Chen-Bin Lv, Yong-He Wu, Wen-Wu Qiu, Yu-Bin Ma, Ju Wu, Chang-Yue Zheng, Guo-Sheng Lin, Ping Li, Jia-Bin Wang, Jian-Xian Lin, Mi Lin, Ru-Hong Tu, Chao-Hui Zheng, Chang-Ming Huang…
    Citation: BMC Cancer 2025 25:460
    Content type: Research Published on:

  44. Pakistan has a high prevalence of oral cavity cancer (OCC) with a significant recurrence rate. This study aims to explore the factors associated with OCC recurrence in Karachi, Pakistan.

    Authors: Uzma Shamsi, Muhammad Shahzaib Arshad, Yasmin Abdul Rashid, Hamzah Jehanzeb and Hamdan Ahmed Pasha
    Citation: BMC Cancer 2025 25:459
    Content type: Research Published on:

  46. One major topic in colorectal cancer (CRC) research is the role of immune cells against cancer cells. The association of single-nucleotide polymorphisms (SNPs) and polygenic risk scores (PRS) with CRC was exam...

    Authors: Dabin Yun, Jung-Ho Yang, Soyoun Yang, Jin-ah Sim, Minjung Kim, Ji Won Park, Seung Yong Jeong, Aesun Shin, Sun-Seog Kweon and Nan Song
    Citation: BMC Cancer 2025 25:456
    Content type: Research Published on:

  47. This study aimed to investigate the potential of circulating small RNAs (sRNAs) as predictive biomarkers for future colorectal cancer (CRC). The study analyzed serum samples from pre-diagnostic CRC patients in...

    Authors: Eva Hofsli, Pål Sætrom, Eivind Ness-Jensen, Helja-Marja Surcel and Robin Mjelle
    Citation: BMC Cancer 2025 25:455
    Content type: Research Published on:

  48. breast cancer is common and highly malignant, currently, STMN1 was found to be associated with several human malignancies. The purpose of this study is to investigate STMN1 expression in breast cancer and expl...

    Authors: Li Qian, Zhu Cairong, Liao Yongdong, Li Quan, Zhong Haihu, Zhu Xiaofeng, Ye Xuan, Chen Yongcheng, Chen Kai, Lu Guanming and Li Jie
    Citation: BMC Cancer 2025 25:453
    Content type: Research Published on:

  49. Major salivary gland tumors (MSGTs) are rare and pose significant treatment challenges. This study investigates the efficacy and safety of particle beam radiotherapy (PBRT) for patients with newly-diagnosed MS...

    Authors: Qingting Huang, Jiyi Hu, Weixu Hu, Jing Gao, Haojiong Zhang, Jiade Jay Lu and Lin Kong
    Citation: BMC Cancer 2025 25:452
    Content type: Research Published on:

  50. To our knowledge, the current status of and barriers to cancer rehabilitation in palliative care units (PCUs) in Japan remain to be elucidated. If clarified, this information could help develop rehabilitation ...

    Authors: Takuya Fukushima, Tetsuya Tsuji, Kazunori Takashima and Jiro Nakano
    Citation: BMC Cancer 2025 25:451
    Content type: Research Published on:

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