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  1. This trial wants to ascertain whether the RAPID procedure could improve graft availability and patient survival in hepatocellular carcinoma (HCC) setting. RAPID-HCC trial, which aims to decrease waiting times ...

    Authors: Andrea Peloso, Daniel Pietrasz, Etienne Daillier, Laurent Cylly, Olivier Scatton, Claire Goumard, Jean-Yves Mabrut, Kayvan Mohkam, Mickael Lesurtel, Safi Dokmak, Heithem Jeddou, Karim Boudjema, Marc-Antoine Allard, René Adam, Antonio Sa Cunha, Daniel Azoulay…
    Citation: BMC Cancer 2025 25:848
    Content type: Study Protocol Published on:

  2. Increasing pulmonary nodule presentations in lung adenocarcinoma patients reveal diagnostic limitations of CT-based invasiveness assessment. The critical unmet need lies in developing non-invasive biomarkers d...

    Authors: Junbao Zhang, Zhihan Zhang, Yuying Liu, Yanyi Hou, Ruifang Pang, Yuenan Wang and Ping Xu
    Citation: BMC Cancer 2025 25:844
    Content type: Research Published on:

  3. CDK4/6 inhibitors plus aromatase inhibitors (AI) significantly improve the therapeutic effect of initial treatment for HR + /HER2- advanced breast cancer. However, there is a lack of head-to-head randomized co...

    Authors: Yanrong Kang, Bing Han, Yongmei Kong, Shuai Liu and Nan Zhang
    Citation: BMC Cancer 2025 25:843
    Content type: Systematic Review Published on:

  4. Gene fusions are an important driver of cancer and require rapid and accurate detection to guide clinical decisions. However, the performance characteristics of whole transcriptome sequencing (WTS) for the det...

    Authors: Songchen Zhao, Xinhua Du, Yan Zhang, Jing Bai, Lu Meng, Xuefei Li, Jiaxin Ma, HeYu Sheng, Xiaorui Fu, Yanfang Guan, Yuting Yi, Ling Yang, Xuefeng Xia, Xin Yi, Xinxin Tan and Caicun Zhou
    Citation: BMC Cancer 2025 25:842
    Content type: Research Published on:

  6. The objective is to systematically gather relevant research to determine and quantify the risk factors and pooled prevalence for pneumonia after a radical gastrectomy for gastric cancer.

    Authors: Siyue Fan, Hongzhan Jiang, Qiuqin Xu, Jiali Shen, Huihui Lin, Liping Yang, Doudou Yu, Nengtong Zheng and Lijuan Chen
    Citation: BMC Cancer 2025 25:840
    Content type: Research Published on:

  7. Sarcopenia is characterized by the loss of muscle strength and mass and is associated with poorer clinical outcomes in women with breast cancer. However, no specific tool is capable of assessing the risk of sa...

    Authors: Vanusa Felicio de Souza Mamede, Rayne de Almeida Marques Bernabé, Thalita Gonçalves Santos, Larissa Leopoldino da Silva, Mariana de Souza Vieira, José Luiz Marques-Rocha and Valdete Regina Guandalini
    Citation: BMC Cancer 2025 25:839
    Content type: Research Published on:

  8. The development of systemic therapy, including targeted drugs and immune checkpoint inhibitors, has significantly improved the prognosis of patients with advanced unresectable hepatocellular carcinoma (uHCC). ...

    Authors: Kugeluke Yalikun, Zhongchao Li, Jianxin Zhang, Zhibin Chang, Mingming Li, Zhicheng Sun, Zhaogang Liu, Yue Yang, Lei Xu, Lei Li, Chengsheng Zhang, Pengfei Sun, Jingtao Zhong, Kai Cui, Xuetao Shi, Bo Zhang…
    Citation: BMC Cancer 2025 25:838
    Content type: Research Published on:

  9. Several observational studies have reported epidemiologic associations between psoriasis and risk of some cancers, but systematic evidence is lacking. Our aim was to comprehensively estimate the association be...

    Authors: Mengsi Liu, Zhen Sun, Peixin Tan, Dehuan Xie, Yantan Liu, Wenqing Feng, Chen Ren and Shasha Du
    Citation: BMC Cancer 2025 25:837
    Content type: Research Published on:

  10. Daratumumab is a human IgGκ monoclonal antibody targeting CD38 with direct on-tumor and immunomodulatory mechanisms of action. Daratumumab-based treatment is a standard of care for multiple myeloma (MM) based ...

    Authors: Luqun Wang, Wei Yang, Yafei Wang, Ting Niu, Rong Fu, Yuping Zhong, Wenbin Qian, Kaiyang Ding, Kai Sun, Hong Liu, Baijun Fang, Hui Liu, Yanhui Li, Yishen Yang, Jianmin Zhuo, Xi Chen…
    Citation: BMC Cancer 2025 25:836
    Content type: Research Published on:

  11. Black and Hispanic cancer survivors experience significant inequities in supportive cancer care. Incorporating cultural appropriateness strategies and behavioral frameworks into supportive care interventions c...

    Authors: Evelyn Arana-Chicas, Yingting Zhang, Arlette Chávez-Iñiguez, Po-Ju Lin, Lindsey J. Mattick, Charles Kamen, Viktor Clark, Francisco Cartujano-Barrera and Karen M. Mustian
    Citation: BMC Cancer 2025 25:835
    Content type: Systematic Review Published on:

  12. The early prediction of lymph node positivity (LN+) after neoadjuvant chemotherapy (NAC) is crucial for optimizing individualized treatment strategies. This study aimed to integrate radiomic features and clini...

    Authors: Tong Ling, Zhichao Zuo, Mingwei Huang, Jie Ma and Liucheng Wu
    Citation: BMC Cancer 2025 25:834
    Content type: Research Published on:

  13. Triple-negative breast cancer (TNBC) has a poor prognosis, and neoadjuvant chemotherapy (NACT) is the standard treatment for locally advanced TNBC. In this study, we aimed to evaluate the efficacy of adding ca...

    Authors: Sedat Yıldırım, Tugba BaÅŸoÄŸlu, Akif DoÄŸan, Goncagul AkdaÄŸ, Oguzcan KınıkoÄŸlu, Alper Topal, Ozkan Alan, Ali Alper Solmaz, Mustafa Gürbüz, Timucin Çil, Rumeysa Çolak, Mesut Yılmaz, Ali Kalem, Nadiye Sever, Nargiz Majıdova, Kubilay Karakoyun…
    Citation: BMC Cancer 2025 25:833
    Content type: Research Published on:

  14. To investigate the prognostic impact of metastatic lymph nodes (MLNs) on advanced epithelial ovarian cancer (EOC) patients receiving neoadjuvant chemotherapy (NACT).

    Authors: Wen Guo, Jie Yin, Yu Gu, Yin Shan, Wei Wang, Yan Li, Meng Qin, Jiayu Chen, Ying Jin and Lingya Pan
    Citation: BMC Cancer 2025 25:832
    Content type: Research Published on:

  15. Immunotherapy, particularly anti-PD-1 therapy, has assumed a progressively significant position in the management of non-small cell lung cancer (NSCLC), especially in lung adenocarcinoma (LUAD). Nevertheless, ...

    Authors: Fengyu Zhao, Han Bai, Yiwei Liu, Shuoze Gao, Chengcheng Yang, Jie Wu, Hao Cheng, Jiao Ma, Yuanyuan Li, Hong Ren, Junke Fu, Shanzhi Gu, Xinhan Zhao and Sida Qin
    Citation: BMC Cancer 2025 25:831
    Content type: Research Published on:

  16. Non-coding RNAs (ncRNAs) play a crucial role in breast cancer progression, necessitating advanced computational approaches for precise disease classification. This study introduces a Deep Reinforcement Learnin...

    Authors: Saleem Ahmad, Imran Zafar, Shaista Shafiq, Laila Sehar, Hafsa Khalil, Nida Matloob, Mehvish Hina, Sidra Tul Muntaha, Hamid Khan, Najeeb Ullah Khan, Samreen Rana, Ahsanullah Unar, Muhammad Azmat, Muhammad Shafiq, Yousef A. Bin Jardan, Musaab Dauelbait…
    Citation: BMC Cancer 2025 25:830
    Content type: Research Published on:

  17. It has been reported that lncRNA CASC19 is abnormally highly expressed in colorectal cancer (CRC) progression, suggesting that it may regulate the occurrence and metastasis of CRC, but its specific mechanism i...

    Authors: Xiao Zhang, Tingyu Zhao, Cheng Wu, Hengyang Shen, Jianing Yi and Lingxiang Liu
    Citation: BMC Cancer 2025 25:829
    Content type: Research Published on:

  18. To evaluate the clinical utility of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)-derived clinicoradiological characteristics and intratumoral/peritumoral radiomic features in predicting patho...

    Authors: Yuting Yang, Tingting Liao, Xiao-Hui Lin, Rushan Ouyang, Qiu Chen and Jie Ma
    Citation: BMC Cancer 2025 25:828
    Content type: Research Published on:

  19. Cancer-related fatigue (CRF) is one of the most prevalent symptoms, but its prevalence and associated risk factors remain inconsistent across studies.

    Authors: Jie Zhao, Liuyan Zhan, Yuanyuan Pang, Shujie Shen, Jie Huang, Wenjia Zhang and Siqi Wei
    Citation: BMC Cancer 2025 25:827
    Content type: Systematic Review Published on:

  20. It is well-recognized that inflammation is an adaptive pathophysiological response in many types of cancer. Research on nutrition's critical role in inflammation, a risk factor for all forms of cancer, is grow...

    Authors: Hossein bahraami Yarahmadi, Kianoush Shahryari, Mahdi Bozorgi, Ahmadreza Shirdel, Zhina Mohamadi, Negar Rooshenas, Helia Karim Nezhad, Hesam Mobaraki, Majid Aryannejad, Anahita Emdadi, Yekta Khosravian, Seyed Amirabbas Shahidi Marnani, Seyyed Kiarash SadatRafiei, Mahsa Asadi Anar, Amir Marashi, Farbod Khosravi…
    Citation: BMC Cancer 2025 25:826
    Content type: Systematic Review Published on:

  21. Oral mucositis (OM) is a debilitating treatment-related complication that affects most children undergoing chemotherapy. This dual-arm clinical trial aimed to evaluate the efficacy of photobiomodulation (PBM) ...

    Authors: Fatemeh Lavaee, Fahimeh Rezazadeh, Ali Amanati, Asma Sookhakian, Mohammad Amin Amiri, Navid Dehghani and Kiarash Fereidouni
    Citation: BMC Cancer 2025 25:825
    Content type: Research Published on:

  23. Salvage neck dissection (ND) is the treatment of choice for residual neck disease after (chemo)radiotherapy for head-and-neck squamous cell carcinoma (HNSCC). Although ND is a relatively safe surgical procedur...

    Authors: Arash Navran, Zeno A. R. Gouw, Willem M. Klop, Willem H. Schreuder, Maarten L. Donswijk, Emilia Owers, Jan Paul de Boer, Laura Smit, Luc Karssemakers, Michiel van den Brekel and Abrahim Al-Mamgani
    Citation: BMC Cancer 2025 25:823
    Content type: Research Published on:

  24. Given the limitations of conventional therapies in prostate cancer (PCa) management, identifying novel biomarkers capable of predicting tumor prognosis and immunotherapy response is critically important. This ...

    Authors: Jing Zhai, Shiwei Liu, Tiantian Wang, Yi Wang and Yu Peng
    Citation: BMC Cancer 2025 25:822
    Content type: Research Published on:

  25. Head and neck squamous cell carcinoma (HNSCC) is a lethal malignancy with a high recurrence and distant metastasis rate, posing significant challenges to patient prognosis. Recent studies suggest that tumor-as...

    Authors: Haiyang Cui, Zhikai Li, Yukun Liu, Yuchuan Yang, Linkuan Huangfu, Jinglin Kong, Xiaocong Sun, Shibo Gao, Daoke Yang and Yingjuan Zheng
    Citation: BMC Cancer 2025 25:821
    Content type: Research Published on:

  26. Cancer biomarker discovery is essential for early detection and monitoring, yet there is a lack of comprehensive studies examining organ-specific biomarkers across various cancer types. In this study, we analy...

    Authors: Zhenglin Chang, Bingsen Chen, Suilin Wang, Kaipai Chen, Linliang Huang, Yi Yang, Haojie Wu, Wenhua Jian, Zhangkai J. Cheng, Xiujing Han and Baoqing Sun
    Citation: BMC Cancer 2025 25:820
    Content type: Research Published on:

  27. It is challenging to identify Papillary Thyroid Cancer (PTC) which shows atypia of undetermined significance (AUS) by Fine-needle Aspiration (FNA). This study aims to seek the meaningful quantitative biomarker...

    Authors: Qingsong Wang, Zhewei Li, Jie Zhang, Sijie Zhang, Lijun Wang, Hongjian Yao, Hong Zhang, Jing Li, Shuo Wang, Jinglai Sun, Wenhui Zhang and Hui Yu
    Citation: BMC Cancer 2025 25:819
    Content type: Research Published on:

  28. Epidermal growth factor receptor (EGFR) mutations are present in 10–60% of all non-small cell lung cancer (NSCLC) patients and are associated with dismal prognosis. Lung cancer brain metastases (LCBM) are a co...

    Authors: Bardia Hajikarimloo, Ibrahim Mohammadzadeh, Salem M. Tos, Mohammad Amin Habibi, Rana Hashemi, Ehsan Bahrami Hezaveh, Dorsa Najari, Arman Hasanzade, Mehdi Hooshmand and Sara bana
    Citation: BMC Cancer 2025 25:818
    Content type: Systematic Review Published on:

  29. Alanine Serine Cysteine transporter 2 (ASCT2/SLC1A5) is a key glutamine transporter in cancer cells and has been shown in a variety of cancers to promote tumor growth by reprogramming glutamine metabolism and ...

    Authors: Fengling Shan, Lan Wang, Xinyu Lu, Meihong Zhou, Zi Wang, Jingjing Lou and Xingdang Liu
    Citation: BMC Cancer 2025 25:817
    Content type: Research Published on:

  30. Liver cancer is one of the most common malignant tumours in humans, and a large proportion of patients are diagnosed at an advanced stage due to rapid growth and distant metastasis; thus, there is an urgent ne...

    Authors: Changsong Ma, Qingsong Yang, Gaoyuan Yu, Ao Li, Congyin Tu, Jian Wang, Wei Zhang, Lin Chen, Da Teng, Qinweng Wang, Yongjun Shao, Yang Zhang and Wengjun Zhang
    Citation: BMC Cancer 2025 25:816
    Content type: Research Published on:

  31. Accurately resolving the composition of tumor-infiltrating leukocytes is pivotal for advancing cancer immunotherapy strategies. Despite the success of some clinical trials, applying these strategies remains li...

    Authors: Shu-Hwa Chen, Bo-Yi Yu, Wen-Yu Kuo, Ya-Bo Lin, Sheng-Yao Su, Wei-Hsuan Chuang, I.-Hsuan Lu and Chung-Yen Lin
    Citation: BMC Cancer 2025 25(Suppl 1):733
    Content type: Research Published on:

    This article is part of a Supplement: Volume 25 Supplement 1

  32. Although IDH-mutant glioma generally has a better prognosis than their IDH-wildtype counterparts, considerable prognostic heterogeneity persists among patients with the same IDH mutation. Current study has pri...

    Authors: Peng Wang, Jiayi Wang, Zheng Fang, Qiaodong Chen, Ying Zhang, Xiaoguang Qiu and Zhaoshi Bao
    Citation: BMC Cancer 2025 25:815
    Content type: Research Published on:

  33. Abnormal glycosylation modification is closely related to the development and metastasis of cancers. As a carcinogen by the International Agency for Research on Cancer (IARC) of the WHO, areca nut lacked of co...

    Authors: Shicheng Kuang, Sha Xiao, Jing Zhou, Lirong Liu, Na Li, Yipeng Ding, Pengfei Lyu, Chaoyong Zhu and Ping Xue
    Citation: BMC Cancer 2025 25:814
    Content type: Research Published on:

  34. The tumor microenvironment (TME) is increasingly acknowledged as a determinant in the malignant transformation and progression of castration-resistant prostate cancer (CRPC). Cancer-associated fibroblasts (CAF...

    Authors: Yifeng Qiu, Yuhan Wang, Jiahe Liu, Kai Sun, Baohua Liu and Qi Hou
    Citation: BMC Cancer 2025 25:813
    Content type: Research Published on:

  35. Approximately half of urothelial carcinoma (UC) patients exhibit low or null HER2 expression. Limited data are available on the efficacy of anti-HER2 RC48-ADC (Disitamab Vedotin) in HER2 low and null advanced UC.

    Authors: Daining Wang, Manming Cao, Yijun Zhang, Liangkuan Bi, Meiting Chen, Mengqian Ni, Qiufan Zheng, Kai Yao, Zhuowei Liu, Xia Yang, Yanxia Shi, Zhiming Wu and Xin An
    Citation: BMC Cancer 2025 25:812
    Content type: Research Published on:

  36. This study aimed to compare oncological outcomes and complication rates between radical hysterectomy (RH) and concurrent chemoradiotherapy (CCRT) in patients with stage IIICr cervical cancer without parametria...

    Authors: Hee Yeun Yoon, Jong Mi Kim, Yoon Young Jeong, Yoon Hee Lee, Min Ju Kim, Yoon Seok Choi, Jung Min Ryu and Gun Oh Chong
    Citation: BMC Cancer 2025 25:811
    Content type: Research Published on:

  38. Advancements in the management of gastric cancer (GC) and innovative therapeutic approaches highlight the significance of the role of biomarkers in GC prognosis. Machine-learning (ML)-based methods can be appl...

    Authors: Haniyeh Rafiepoor, Mohammad M. Banoei, Alireza Ghorbankhanloo, Ahad Muhammadnejad, Amirhossein Razavirad, Saeed Soleymanjahi and Saeid Amanpour
    Citation: BMC Cancer 2025 25:809
    Content type: Research Published on:

  39. Most cases of upper tract urothelial carcinoma (UTUC) exhibit recurrence within the first year following surgery. The time from surgery to recurrence significantly impacts cancer-specific survival. In this stu...

    Authors: Yi-Ju Chou, Hao-Lun Luo, Hung-Jen Wang, Steven K. Huang, Yu-Che Hsieh, Wen-Jeng Wu, Ching-Chia Li, Han-Yu Weng, Ta-Yao Tai, Chao-Hsiang Chang, Hsi-Chin Wu, Po-Hung Lin, Jacob See-Tong Pang, Chung-Hsin Chen, Jian-Hua Hong, Jen-Shu Tseng…
    Citation: BMC Cancer 2025 25:808
    Content type: Research Published on:

  40. Aspirin and non-aspirin non-steroidal anti-inflammatory drugs (NA-NSAID) have been associated with improved survival in individuals with epithelial ovarian cancer (EOC); however, findings to date are inconsist...

    Authors: Nathalie C. Støer, Edoardo Botteri, Kristina Lindemann, Hilde Langseth and Renée Turzanski Fortner
    Citation: BMC Cancer 2025 25:807
    Content type: Research Published on:

  41. Diffuse large B-cell lymphoma (DLBCL) is an aggressive lymphoma and DLBCL cells are highly sensitive to ferroptosis. The purpose of this research was to evaluate the role and molecular mechanism of peroxiredox...

    Authors: Chuanming Lin, Shuiling Xie, Menger Wang and Jianzhen Shen
    Citation: BMC Cancer 2025 25:806
    Content type: Research Published on:

  42. Life’s Crucial 9 (LC9) is a recently proposed cardiovascular health (CVH) scoring system that integrates psychological well-being with Life’s Essential 8 (LE8). However, its prognostic value remains unclear. T...

    Authors: Hongyang Gong, Ming Gao and Zhiwen Zeng
    Citation: BMC Cancer 2025 25:805
    Content type: Research Published on:

  44. The epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein that is overexpressed in various epithelial tumors and has been associated with tumor aggressiveness and unfavorable prognosis. Thi...

    Authors: Xia Zhang, Jie Li, Ming Gao and Yan Zhang
    Citation: BMC Cancer 2025 25:803
    Content type: Research Published on:

  45. This study aimed to investigate the incidence of post radiation nasopharyngeal necrosis (PRNN) in primary NPC after intensity modulated radiation therapy (IMRT) and identify the predictors of risk.

    Authors: Xing-Li Yang, Li Lin, Sha-Sha He, Dan-Wan Wen, Jia Kou, Yan Wang, Xue-Cen Wang and Yong Chen
    Citation: BMC Cancer 2025 25:802
    Content type: Research Published on:

  46. Chronic hepatitis B virus (HBV) infection poses a significant global public health challenge and is found closely related to extrahepatic cancers, including head and neck cancer. Oral squamous cell carcinoma (...

    Authors: Rukeng Tan, Yiyao Zhu, Zengyu Chen, Xinkai Feng, Yujie Liang, Sien Zhang, Nuerbiya Abuduxiku, Guiqing Liao and Le Yang
    Citation: BMC Cancer 2025 25:801
    Content type: Research Published on:

  47. Studies on sex-related differences in post-lung cancer surgery symptoms are limited. Understanding these differences may provide insights into patient recovery. Therefore, we investigated sex-related differenc...

    Authors: Jia Liao, Xiaoqun Hu, Xing Wei, Wei Dai, Hongfan Yu, Xin Tian, Yaqin Wang, Qin Qin, Na Xu, Yuanyuan Li, Qiang Li, Qiuling Shi and Xiaoqin Liu
    Citation: BMC Cancer 2025 25:800
    Content type: Research Published on:

  48. Mitochondria play a multifaceted role in tumorigenesis, influencing energy metabolism, redox balance, and apoptosis. However, whether mitochondrial traits causally affect cancer risk remains unclear. This stud...

    Authors: Jincheng Tang, Jingting Zhang, Renyi Yang, Hongyao Chen, Xiaopeng Yu, Wei Peng and Puhua Zeng
    Citation: BMC Cancer 2025 25:794
    Content type: Research Published on:

  49. Cholangiocyte phenotype hepatocellular carcinoma (HCC) is highly invasive. This study aims to develop and validate an optimal machine learning model to predict cholangiocyte phenotype HCC based on T1 mapping g...

    Authors: Wei Liu, Zhiping Cai, Yifan Chen, Xingqun Guan, Jieying Feng, Haixiong Chen, Baoliang Guo, Fusheng OuYang, Chun Luo, Rong Zhang, Xinjie Chen, Xiaohong Li, Cuiru Zhou, Shaomin Yang, Ziwei Liu and Qiugen Hu
    Citation: BMC Cancer 2025 25:788
    Content type: Research Published on:

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