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  1. The objective of this study was to investigate the clinical and genetic characteristics and clinical relevance of HER2 exon 20 oncogenic variants in non-small cell lung cancer (NSCLC) patients.

    Authors: Yating Hou, Xingyang Xue, Zhuoyun Zhang, Dahai Mai, Wei Luo, Mingyu Zhou, Zichuan Liu and Yisheng Huang
    Citation: BMC Cancer 2025 25:752
    Content type: Research Published on:

  2. As part of the innate immune system, NK cells contribute to optimizing cancer immunotherapy strategies and are becoming a focal point in cancer research. However, limited research has been conducted to further...

    Authors: Chunlan Liu, Tianjian Ding, Rong Zou, Aili Zhang, Zhengzhuo Zhi and Sili Wang
    Citation: BMC Cancer 2025 25:745
    Content type: Research Published on:

  3. The pre-diagnosis plasma proteomic contexture of colon cancer patients may reflect host immune and biological conditions and potentially associate with survival outcomes. We aimed to characterize pre-diagnosis...

    Authors: Shun Li, Hao Wang, Xiao-Qian Xu, Wei-Ming Li, Hong You, Ji-Dong Jia, You-Wen He and Yuan-Yuan Kong
    Citation: BMC Cancer 2025 25:744
    Content type: Research Published on:

  4. In patients with metastatic colorectal cancer, analysis of the number of basal circulating tumour cells (bCTCs) has been shown to be a strong prognostic indicator. In this study, we aim to explore the potentia...

    Authors: Manuel Valladares-Ayerbes, Marta Toledano-Fonseca, Begoña Graña, Paula Jimenez-Fonseca, Gema Pulido-Cortijo, Silvia Gil, Javier Sastre, Antonieta Salud, Fernando Rivera, Mercedes Salgado, Pilar García-Alfonso, Rafael López López, Carmen Guillén-Ponce, Antonio Rodríguez-Ariza, Jose Mª Vieitez, Eduardo Díaz-Rubio…
    Citation: BMC Cancer 2025 25:743
    Content type: Research Published on:

  5. Mecapegfilgrastim has been previously validated for efficacy and safety in neutropenia prevention during clinical trials. This nationwide, real-world study (RWS) evaluates its role in protecting against modera...

    Authors: Shukui Qin, Yanxia Shi, Peifen Fu, Nong Xu, Chenyu Mao, Yong Chen, Yongsheng Wang, Huiqiang Huang, Xin Huang, Yongqing Li, Haijiao Yan, Yumin Yao, Gang Cheng, Zhe Yang, Ningling Zhang, Guifang Zhang…
    Citation: BMC Cancer 2025 25:742
    Content type: Research Published on:

  6. Sarcopenia (defined as low skeletal muscle index - SMI) and myosteatosis (defined as low skeletal muscle radiodensity - SMD) associate with poor outcomes in gastric cancer, but their impact after robotic surge...

    Authors: Honghai Guo, Sheng Chen, Tao Zheng, Ping’an Ding, Jiaxuan Yang, Haotian Wu, Jiaxiang Wu, Li Yang, Yuan Tian, Peigang Yang, Xianyu Tang and Qun Zhao
    Citation: BMC Cancer 2025 25:741
    Content type: Research Published on:

  7. Financial Toxicity (FT) is prevalent among lung cancer patients. Identifying high-risk groups and implementing comprehensive, targeted interventions can alleviate FT and improve patients’ quality of life. Henc...

    Authors: Xu Zhang, Liwei Zhang, Ziyi Geng, Meimei Shang, Aijun Wang, Xing Zheng, Chao Li, Tingting Zhang, Hailing Yang and Yuanyuan Chen
    Citation: BMC Cancer 2025 25:740
    Content type: Research Published on:

  8. Cervical cancer (CC) is a major public health problem; it is the fourth leading cause of cancer in women worldwide. The present study aimed to analyze trends and projections in incidence of CC in northern Tuni...

    Authors: Hyem Khiari, Yasmine Ben Abdelfatteh, Najet Mahjoub, Karima Mekni, Ashraf Chadli, Wafa Aissi and Mohamed Hsairi
    Citation: BMC Cancer 2025 25:739
    Content type: Research Published on:

  9. DET has a significant inhibitory activity against a range of cancer cells; however, its specific effects and underlying mechanisms in Non-Small Cell Lung Cancer (NSCLC) remain to be fully elucidated. This stud...

    Authors: Shenjia Wu, Ying Guo and Rong Wang
    Citation: BMC Cancer 2025 25:738
    Content type: Research Published on:

  10. The high mortality rate of breast cancer and the difficulties associated with therapeutic resistance, especially in cases where targeted treatments are unavailable, make it a serious threat to women's health. ...

    Authors: Harshi Gupta, Anushka Raghubansi, Bharat, Kritika Sharma, Krittika Zutshi, Partibha Panchal, Sushant Bhattacharya, Piyush Ranjan, Gopal Puri and Neeru Saini
    Citation: BMC Cancer 2025 25:737
    Content type: Research Published on:

  11. External beam radiation therapy (RT) has shown promising effects for hepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT) in recent studies. However, there is still a lack of consen...

    Authors: Sang Min Lee, Jin Hwa Choi, Jung-Hwan Yoon, Yoon Jun Kim, Su Jong Yu, Jeong-Hoon Lee, Hyun-Cheol Kang, Eui Kyu Chie and Kyung Su Kim
    Citation: BMC Cancer 2025 25:736
    Content type: Research Published on:

  12. Ewing’s sarcoma (ES) is a highly aggressive primary bone malignancy that primarily affects children and adolescents. Several tyrosine kinase receptors (RTKs) have been found to be overexpressed in ES samples, ...

    Authors: Ahmad Assi, Mohamad Farhat, Rami Mohanna, Maria Catherine Rita Hachem, Ziad Zalaquett, Marven Aoun, Sami Abi Farraj, Mohammad Daher, Amer Sebaaly and Hampig-Raphaël Kourie
    Citation: BMC Cancer 2025 25:735
    Content type: Systematic Review Published on:

  13. To investigate the value of virtual magnetic resonance elastography (vMRE), fractional order calculus (FROC) model, and diffusion-weighted imaging (DWI) in differentiating rectal cancer grades.

    Authors: Shuaina Wang, Xingxing Jin, Yiwen Ba, Wenling Liu, Jipeng Ren, Lunpu Ai, Hao Li, Fengmei Zhou, Dongming Han, Kaiyu Wang and Ruifang Yan
    Citation: BMC Cancer 2025 25:734
    Content type: Research Published on:

  14. Acquired MET alterations is one of the resistance mechanisms to advanced NSCLC patients treated with EGFR tyrosine kinase inhibitors (TKIs). Several clinical trials combined MET-TKI (such as capmatinib, tepoti...

    Authors: Defeng Hu, Yixuan Hu, Shipeng Lei, Dongdong Wu and Yubo Wang
    Citation: BMC Cancer 2025 25:732
    Content type: Systematic Review Published on:

  15. The work aimed to compare the efficacy and safety of chemotherapy regimen (oxaliplatin + capecitabine, XELOX) combined with neoadjuvant radiotherapy (NART) and neoadjuvant chemotherapy (NACT) in locally advanc...

    Authors: Shanshan Bu, Siyi Wang, Ting Wang, Hang Xing, Yue Cao, Zhandong Zhang, Chuang Shang, Xiance Tang, Yifei Liu, Xiaoqun Dong and Xiushen Wang
    Citation: BMC Cancer 2025 25:731
    Content type: Research Published on:

  16. Mammographic screening is effective in reducing breast cancer mortality, but the impact of screening on triple-negative breast cancers (TNBCs) outcomes remains debated. This study aims to determine if screen d...

    Authors: Isabella Castellano, Stefano Rousset, Denise Casella, Giulia Capella, Fulvio Borella, Martina Di Rosa, Paola Cassoni, Alberto Catalano, Gianluigi Ferrante and Livia Giordano
    Citation: BMC Cancer 2025 25:730
    Content type: Research Published on:

  17. Gastroesophageal reflux disease (GERD) is increasingly recognized for its associations with extragastric diseases, yet its potential role in pancreatic cancer (PC) etiology remains underexplored. This study in...

    Authors: Chen Yang, Fan Ge, Mengye Peng, Liang Cheng, Kezheng Wang and Wei Liu
    Citation: BMC Cancer 2025 25:729
    Content type: Research Published on:

  18. Extracting image features can predict the prognosis and treatment effect of non-small cell lung cancer, which has been increasingly confirmed. However, the specific operation using 3D-Slicer still lacks standa...

    Authors: Chunmei Liu, Yuzheng He and Jianmin Luo
    Citation: BMC Cancer 2025 25:728
    Content type: Research Published on:

  19. Well-implemented cancer screening strategies can significantly enhance early detection rates, leading to improved treatment outcomes and reduced mortality. However, there remains a paucity of high-quality evid...

    Authors: Yibo Gao, Ping Hu, Ning Wu, Fengwei Tan, Wei Cao, Wei Tang, Fei Wang, Jiang Li, Xin Li, Yan Wen, Yongjie Xu, Yiwen Yu, Chao Qin, Xuesi Dong, Jiansong Ren, Zhuoyu Yang…
    Citation: BMC Cancer 2025 25:727
    Content type: Study Protocol Published on:

  21. Soft tissue sarcomas (STS) are a rare group of malignant tumors originating from soft tissues. The study systematically evaluates the global burden of soft tissue and extraosseous sarcomas from 1990 to 2021 ac...

    Authors: Mingxia Zhu, Lan Zhang, Yong Wei, Xiaping Wang, Songbing Qin, Tongshan Wang, Xiaoting Xu and Xin Zhou
    Citation: BMC Cancer 2025 25:725
    Content type: Research Published on:

  22. The relationship between circulating tumor cells (CTCs) and patients with advanced gallbladder adenocarcinoma (aGA) has been rarely studied. This article was to demonstrate the enumeration, classification, and...

    Authors: Chun Liu, Cheng Yan, Weichang Zhang, Yuxin Sun, Youjun Lin and Wenwu Cai
    Citation: BMC Cancer 2025 25:724
    Content type: Research Published on:

  23. Based on SOFT and TEXT trials data, a composite recurrence risk score (CR-score) model was developed for early premenopausal women with hormone receptor -positive (HR+), human epidermal growth factor receptor ...

    Authors: Weibin Lian, Liangqiang Li, Debo Chen and Chengye Hong
    Citation: BMC Cancer 2025 25:723
    Content type: Research Published on:

  24. Pancreatic cancer (PC) is a highly lethal malignancy, ranking seventh among cancer-related deaths worldwide. This study utilizes data from the 2021 Global Burden of Disease (GBD) study to examine the global bu...

    Authors: Wei Liu, Li Rao, Zhengguo Qiao, Gang Wang, Bin Li and Genhai Shen
    Citation: BMC Cancer 2025 25:722
    Content type: Research Published on:

  25. A significant proportion, ranging from 20 to 40%, of individuals with hepatocellular carcinoma (HCC) do not exhibit elevated Alpha-fetoprotein (AFP) levels. This study aimed to evaluate the utility of serum gl...

    Authors: Yingying Lin, Yuefei Ma, Yan Chen, Yepei Huang, Jinchuan Lin, Zhenzhou Xiao and Zhaolei Cui
    Citation: BMC Cancer 2025 25:721
    Content type: Research Published on:

  26. Medical writing services, initially developed to streamline manuscript preparation, have raised ethical concerns due to their association with industry influence and spin. While prevalent in oncology and malig...

    Authors: Héctor A. Vaquera-Alfaro, Elham Nasrollahi, Yashvin Onkarappa Mangala, David Russler-Germain, Aaron Goodman and Ghulam Rehman Mohyuddin
    Citation: BMC Cancer 2025 25:720
    Content type: Research Published on:

  28. To improve prognosis of patients with synchronous colorectal liver metastasis (CRLM), we constructed a nomogram model to improve outcome through risk stratification and decision support.

    Authors: Jun-shuai Xue, Nuersimanguli Maimaitiming, Bo-lun Zhang, Bo-wen Xu, Xin Yin, Zhen Huang, Xu Che, Hong Zhao and Jian-qiang Cai
    Citation: BMC Cancer 2025 25:718
    Content type: Research Published on:

  29. Bladder cancer (BLCA) is a highly heterogeneous disease that presents challenges in predicting prognosis and treatment response. Cancer stem cells are key drivers of tumor development, progression, metastasis,...

    Authors: Heping Qiu, Xiaolin Deng, Jing Zha, Lihua Wu, Haonan Liu, Yichen Lu and Xinji Zhang
    Citation: BMC Cancer 2025 25:717
    Content type: Research Published on:

  30. Glucose transporter 1 (GLUT1) is known to play a crucial role in glucose uptake in malignant tumors. GLUT1 inhibitors reportedly exhibit anti-tumor effects by suppressing cancer cell proliferation. BAY-876, a ...

    Authors: Masato Hayashi, Keishi Nakamura, Shinichi Harada, Mariko Tanaka, Akiko Kobayashi, Hiroto Saito, Toshikatsu Tsuji, Daisuke Yamamoto, Hideki Moriyama, Jun Kinoshita and Noriyuki Inaki
    Citation: BMC Cancer 2025 25:716
    Content type: Research Published on:

  31. The advent of novel therapeutic agents has advanced biomarker characterization in non-small-cell lung cancer (NSCLC), driving increased adoption of next-generation sequencing (NGS) technologies for molecular t...

    Authors: Fang-Yu Wang, Yi-Chen Yeh, Shin-Ying Lin, Shu-Ying Wang, Paul Chih-Hsueh Chen, Teh-Ying Chou and Hsiang-Ling Ho
    Citation: BMC Cancer 2025 25:715
    Content type: Research Published on:

  32. Cyclin-dependent kinase 8 (CDK8) has been implicated in various tumors, with its role differing across tumor types. However, the association between CDK8 polymorphisms and bladder cancer (BC) remains unclear. Thi...

    Authors: Zhilong Li, Min Su, Qin Li, Xuelian Zheng, Yaping Song, Yanyun Wang, Bin Zhou and Lin Zhang
    Citation: BMC Cancer 2025 25:714
    Content type: Research Published on:

  33. This study aims to screen, validate novel biomarkers and develop a user-friendly online tool for the detection of colorectal cancer (CRC).

    Authors: Zan Qiu, Yifan Cheng, Haiyan Liu, Tiandong Li, Yinan Jiang, Yin Lu, Donglin Jiang, Xiaoyue Zhang, Xinwei Wang, Zirui Kang, Lei Peng, Keyan Wang, Liping Dai, Hua Ye, Peng Wang and Jianxiang Shi
    Citation: BMC Cancer 2025 25:713
    Content type: Research Published on:

  34. Within the French-Australian CLL6 RESIDUUM trial, an ancillary study aimed at assessing the health-related quality of life (HRQoL) of patients with chronic lymphocytic leukemia (CLL) receiving a two-year conso...

    Authors: Stephane Kroudia Wasse, Sandrine Tienhan Dabakuyo-Yonli, David Gottlieb, Florence Cymbalista, Stephen Mulligan, Marc Maynadie and Thérèse Aurran-Schleinitz
    Citation: BMC Cancer 2025 25:712
    Content type: Research Published on:

  36. Although quality-assured oncological exercise therapy (qOET) has proven effective for cancer patients at any stage of treatment and during aftercare, it is not yet incorporated into standard care in Germany an...

    Authors: Mirko Brandes, Anika Berling-Ernst, Hansjoerg Baurecht, Wiebke Jensen, Miriam Götte, Anne Herrmann, Daniela Fuhr, Heike Schmidt, Antonia Lucas, Bernardine Madl, Simon Elmers, Thorsten Schmidt, Christine Welker, Andre Golla, Annalena Wehner, Dominik Morlok…
    Citation: BMC Cancer 2025 25:710
    Content type: Study Protocol Published on:

  37. Glioblastoma (GBM) is a challenging malignancy with a poor prognosis. While the neutrophil-to-lymphocyte ratio (NLR) is reported to correlate with the prognosis, the significance of changes in the NLR and its ...

    Authors: Meng-Wu Chung, Ching-Chieh Tzeng, Yin-Cheng Huang, Kuo-Chen Wei, Peng-Wei Hsu, Chi-Cheng Chuang, Ya-Jui Lin, Ko-Ting Chen and Cheng-Chi Lee
    Citation: BMC Cancer 2025 25:709
    Content type: Research Published on:

  38. This study evaluated the effectiveness and safety of tislelizumab plus lenvatinib (TL group) and tislelizumab monotherapy (T group) in patients with stage C hepatocellular carcinoma (HCC) according to the Barc...

    Authors: Jiajin Yang, Qiuping Xu, Sihao Luo and Jianbing Wu
    Citation: BMC Cancer 2025 25:708
    Content type: Research Published on:

  39. Breast cancer represents the most prevalent form of tumors among females and is characterized by a significant genetic component. The brain is a frequent site of metastasis for breast cancer. Although numerous...

    Authors: Jinsong Liu, Xiao Guan, Songlin Gao, Liuliu Quan, Min Dou, Jian Yue, Mengwu Shi and Peng Yuan
    Citation: BMC Cancer 2025 25:707
    Content type: Research Published on:

  40. This retrospective study aimed to compare patients eligible for the Z0011 study with and without axillary lymph node dissection (ALND) by overall survival (OS), disease-free survival (DFS), and loco-regional r...

    Authors: Mehmet Furkan Sağdıç, Burak Dinçer and Cihangir Özaslan
    Citation: BMC Cancer 2025 25:706
    Content type: Research Published on:

  41. Breast cancer treatment has improved significantly, contributing to a 5-year relative survival rate of 99% for localized cases. However, post-treatment survivors are reported to have significantly poor cardiov...

    Authors: Fatima Abdul Rashid, Wajiha Anwar, Praveen Kumar Kandakurti, Khaled H. A. Al Qawasmeh, Muhammad Farooq Latif, Syed Hammad Tirmazy, Mohamed Omara and Animesh Hazari
    Citation: BMC Cancer 2025 25:705
    Content type: Research Published on:

  42. Cancer is a growing public health concern in Africa and Asia, where access to effective healthcare and resources is often limited. There is an urgent need for evidence-based cancer control policies in Africa a...

    Authors: Julie Robin, Clémence Schantz, Madani Ly, Bakary Abou Traore, Kadiatou Faye, Aurélien Dancoisne and Valéry Ridde
    Citation: BMC Cancer 2025 25:704
    Content type: Systematic Review Published on:

  43. Cancer remains a significant health challenge in the ASEAN region, highlighting the need for effective screening programs. However, approaches, target demographics, and intervals vary across ASEAN member state...

    Authors: Hein Minn Tun, Hanif Abdul Rahman, Lin Naing and Owais Ahmed Malik
    Citation: BMC Cancer 2025 25:703
    Content type: Systematic Review Published on:

  44. The aim of this study was to explore the role of microRNA-767-5p (miR-767-5p) in regulating the osteosarcoma (OS) prognosis, metastasis and sensitivity to chemotherapeutic and radiotherapeutic sensitivity. We ...

    Authors: Xuelian Luo, Xiaoyan Dai, Qingsong Wei, Xiaorong Tan, Shuai Wang, Hanxi Xiao, Xuan Yao, Youcai Deng and Zhaoyang Zhong
    Citation: BMC Cancer 2025 25:702
    Content type: Research Published on:

  46. Colorectal cancer (CRC) is the most prevalent malignant tumor of the digestive system globally, ranking third in incidence and second in mortality. In previous studies, the rate of lymph node metastasis (LNM) ...

    Authors: Rui Li, Xu Sun, Zhiyuan Yu, Peiyu Li and Xudong Zhao
    Citation: BMC Cancer 2025 25:700
    Content type: Research Published on:

  47. Chemotherapy side effects can easily contribute to malnutrition and disrupt the normal diet of breast cancer patients. Offering early multidisciplinary team interventions during chemotherapy can establish a so...

    Authors: Han Tang, Wei Zhang, Xiao Li, Qiong Zou, Xiaochun Li, Yue Liu and Haiyan Shen
    Citation: BMC Cancer 2025 25:699
    Content type: Research Published on:

  48. Management of neurofibromatosis type 2 (NF2)- associated vestibular schwannomas (VSs) is challenging due to their multiplicity, early onset, proximity to the brainstem, unpredictable growth, and aggressive beh...

    Authors: Bardia Hajikarimloo, Salem M. Tos, Mohammadamin Sabbagh Alvani, Alireza Kooshki, Ibrahim Mohammadzadeh and Mohammad Amin Habibi
    Citation: BMC Cancer 2025 25:698
    Content type: Research Published on:

  49. Immune checkpoint inhibitor (ICI) plus chemotherapy has become the standard of care for advanced non-small cell lung cancer (NSCLC). Nonetheless, reliable efficacy biomarkers of ICI plus chemotherapy are lacki...

    Authors: Shan Liao, Huiying Sun, Hao Lu, Jiani Wu, Jianhua Wu, Zhe Wu, Jingle Xi, Wangjun Liao and Yuanyuan Wang
    Citation: BMC Cancer 2025 25:697
    Content type: Research Published on:

  50. Emerging evidence suggests the importance of basement membrane components in cancer metastasis; however, their specific roles in esophageal carcinoma remain underexplored. To investigate this, we analyzed 152 ...

    Authors: Lang Xu, Bingna Wang, Chen Wang, Nan Mao, Yating Huang, Xihua Fu, Tao Feng, Qiming He, Yang Zhang, Guoxing You, Xiaojun Ma, Xinsheng Peng and Jianfen Su
    Citation: BMC Cancer 2025 25:696
    Content type: Research Published on:

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