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  1. The fusion protein RUNX1-CBFA2T1 associated with t(8;21)-positive acute myeloid leukaemia is a potent inhibitor of haematopoetic differentiation. The role of RUNX1-CBFA2T1 in leukaemic cell proliferation is le...

    Authors: Natalia Martinez, Bettina Drescher, Heidemarie Riehle, Claire Cullmann, Hans-Peter Vornlocher, Arnold Ganser, Gerhard Heil, Alfred Nordheim, Jürgen Krauter and Olaf Heidenreich
    Citation: BMC Cancer 2004 4:44
    Content type: Research article Published on:

  2. The Hedgehog (Hh) signaling pathway regulates a variety of developmental processes, including vasculogenesis, and can also induce the expression of pro-angiogenic factors in fibroblasts postnatally. Misregulat...

    Authors: Catherine L Olsen, Pin-Pin Hsu, Jens Glienke, Gabor M Rubanyi and Alan R Brooks
    Citation: BMC Cancer 2004 4:43
    Content type: Research article Published on:

  3. Matrix metalloproteinases [MMPs], which degrade the extracellular matrix, play an important role in the invasion and metastasis of squamous cell carcinomas. One MMP, MMP-13, is thought to play a central role i...

    Authors: Nil Culhaci, Kubilay Metin, Eray Copcu and Emel Dikicioglu
    Citation: BMC Cancer 2004 4:42
    Content type: Research article Published on:

  5. Matrix metalloproteinases (MMPs) are central to degradation of the extracellular matrix and basement membrane during both normal and carcinogenic tissue remodeling. MT1-MMP (MMP-14) and stromelysin-3 (MMP-11) ...

    Authors: Saxon Selvey, Larisa M Haupt, Erik W Thompson, Klaus I Matthaei, Michael G Irving and Lyn R Griffiths
    Citation: BMC Cancer 2004 4:40
    Content type: Research article Published on:

  7. Combination therapy of irinotecan, folinic acid (FA) and 5-fluorouracil (5-FU) has been proven to be highly effective for the treatment of metastatic colorectal cancer. However, in light of safety and efficacy...

    Authors: Andreas Teufel, Silke Steinmann, Jürgen Siebler, Christiane Zanke, Herbert Hohl, Bernd Adami, M Schroeder, O Klein, Thomas Höhler, Peter R Galle, Michael Heike and Markus Moehler
    Citation: BMC Cancer 2004 4:38
    Content type: Research article Published on:

  8. Atypical glandular cells on cervical smears are often associated with clinically significant uterine lesions. The frequency and accuracy of AGC-NOS (i.e. atypical glandular cells, not otherwise specified) diag...

    Authors: René Scheiden, Catherine Wagener, Ulrich Knolle, Walter Dippel and Catherine Capesius
    Citation: BMC Cancer 2004 4:37
    Content type: Research article Published on:

  9. This multicentre phase I/II study was designed to determine the maximum tolerated dose of irinotecan when combined with 5-fluorouracil and folinic acid according to the Mayo Clinic schedule and to evaluate the...

    Authors: Thomas Kuehr, Paul Ruff, Bernardo L Rapoport, Stephen Falk, Francis Daniel, Conrad Jacobs, Neville Davidson, Josef Thaler, Blandine Boussard and James Carmichael
    Citation: BMC Cancer 2004 4:36
    Content type: Research article Published on:

  10. The expression profiles of solid tumor models in rodents have been only minimally studied despite their extensive use to develop anticancer agents. We have applied RNA expression profiling using Affymetrix U95...

    Authors: Michael A Gieseg, Michael Z Man, Nicholas A Gorski, Steven J Madore, Eric P Kaldjian and Wilbur R Leopold
    Citation: BMC Cancer 2004 4:35
    Content type: Research article Published on:

  11. The importance of various inflammatory cytokines in maintaining tumor cell growth and viability is well established. Increased expression of the proinflammatory cytokine macrophage migration inhibitory factor ...

    Authors: Katherine L Meyer-Siegler, Erica C Leifheit and Pedro L Vera
    Citation: BMC Cancer 2004 4:34
    Content type: Research article Published on:

  12. BAK (Bcl-2 homologous antagonist/killer) is a novel pro-apoptotic gene of the Bcl-2 family. It has been reported that gastric tumors have reduced BAK levels when compared with the normal mucosa. Moreover, muta...

    Authors: Qiang-Song Tong, Li-Duan Zheng, Liang Wang, Jun Liu and Wei Qian
    Citation: BMC Cancer 2004 4:33
    Content type: Research article Published on:

  13. Following resection of liver metastases from colorectal cancer, 5-year survivals are reportedly 30 – 39%. It can be assumed that this clinical situation represents systemic disease. Therefore, it is postulated...

    Authors: Oliver F Bathe, Scot Dowden, Francis Sutherland, Elijah Dixon, Charles Butts, David Bigam, Barb Walley, Dean Ruether and Scott Ernst
    Citation: BMC Cancer 2004 4:32
    Content type: Study protocol Published on:

  14. A novel member of the Wnt signalling pathway, Chibby, was recently identified. This protein inhibits Wnt/β-catenin mediated transcriptional activation by competing with Lef-1 (the transcription factor and targ...

    Authors: Sophie Gad, David Teboul, Astrid Lièvre, Nicolas Goasguen, Anne Berger, Philippe Beaune and Pierre Laurent-Puig
    Citation: BMC Cancer 2004 4:31
    Content type: Research article Published on:

  15. North central China has some of the highest rates of esophageal squamous cell carcinoma in the world with cumulative mortality surpassing 20%. Mitochondrial DNA (mtDNA) accumulates more mutations than nuclear ...

    Authors: Christian C Abnet, Konrad Huppi, Ana Carrera, David Armistead, Keith McKenney, Nan Hu, Ze-Zong Tang, Philip R Taylor and Sanford M Dawsey
    Citation: BMC Cancer 2004 4:30
    Content type: Research article Published on:

  16. Serum leptin level is associated with appetite and energy expenditure in healthy individuals. We aimed to evaluate the serum leptin concentration and the other factors which may be associated with weight loss ...

    Authors: F Fusun Bolukbas, Hasan Kilic, Cengiz Bolukbas, Mahmut Gumus, Mehmet Horoz, Nazım S Turhal and Birsel Kavakli
    Citation: BMC Cancer 2004 4:29
    Content type: Research article Published on:

  17. The Duffy antigen receptor for chemokines (DARC) is known to be a promiscuous chemokine receptor that binds a variety of CXC and CC chemokines in the absence of any detectable signal transduction events. Withi...

    Authors: Christina L Addison, John A Belperio, Marie D Burdick and Robert M Strieter
    Citation: BMC Cancer 2004 4:28
    Content type: Research article Published on:

  18. Recent evidence suggests that progesterone metabolites play important roles in regulating breast cancer. Previous studies have shown that tumorous tissues have higher 5α-reductase (5αR) and lower 3α-hydroxyste...

    Authors: Michael J Lewis, John P Wiebe and J Godfrey Heathcote
    Citation: BMC Cancer 2004 4:27
    Content type: Research article Published on:

  20. Based on the site of breakpoint in t(9;22) (q34;q11), bcr-abl fusion in leukemia patients is associated with different types of transcript proteins. In this study we have seen the association of HLA genes with di...

    Authors: Shailendra Mundhada, Rajyalakshmi Luthra and Pedro Cano
    Citation: BMC Cancer 2004 4:25
    Content type: Research article Published on:

  21. Signaling networks promoting cell growth and proliferation are frequently deregulated in cancer. Tumors often are highly dependent on such signaling pathways and may become hypersensitive to downregulation of ...

    Authors: Boris W Kramer, Rudolf Götz and Ulf R Rapp
    Citation: BMC Cancer 2004 4:24
    Content type: Research article Published on:

  22. Therapeutic options to effectively inhibit growth and spread of neuroendocrine gastrointestinal tumors are still limited. As both meta-iodobenzylguanidine (MIBG) and interferon-γ (IFNγ) cause antineoplastic ef...

    Authors: Michael Höpfner, Andreas P Sutter, Alexander Huether, Gudrun Ahnert-Hilger and Hans Scherübl
    Citation: BMC Cancer 2004 4:23
    Content type: Research article Published on:

  23. Patients with cancer must make frequent visits to the clinic not only for chemotherapy but also for the management of treatment-related adverse effects. Neutropenia, the most common dose-limiting toxicity of m...

    Authors: Barry V Fortner, Kurt Tauer, Ling Zhu, Theodore A Okon, Kelley Moore, Davis Templeton and Lee Schwartzberg
    Citation: BMC Cancer 2004 4:22
    Content type: Research article Published on:

  25. DNA microarray profiling performed on clinical tissue specimens can potentially provide significant information regarding human cancer biology. Biopsy cores, the typical source of human tumor tissue, however, ...

    Authors: Elizabeth M Goley, Soni J Anderson, Cynthia Ménard, Eric Chuang, Xing Lü, Philip J Tofilon and Kevin Camphausen
    Citation: BMC Cancer 2004 4:20
    Content type: Research article Published on:

  27. Integrin-extracellular matrix interactions activate signaling cascades such as mitogen activated protein kinases (MAPK). Integrin binding to extracellular matrix increases tyrosine phosphorylation of focal adh...

    Authors: David L Crowe and Arthur Ohannessian
    Citation: BMC Cancer 2004 4:18
    Content type: Research article Published on:

  31. Surveillance colonoscopy is commonly recommended following potentially curative surgery for colorectal cancer. We determined factors associated with patients undergoing a least one colonoscopy within five year...

    Authors: Robert J Hilsden, Heather E Bryant, Lloyd R Sutherland, Penny MA Brasher and Anthony LA Fields
    Citation: BMC Cancer 2004 4:14
    Content type: Research article Published on:

  33. Most of the steps involved in the initiation and progression of Hürthle (oncocytic, oxyphilic) cell carcinomas of the thyroid remain unknown.

    Authors: Valdemar Máximo, Ana Preto, Ana Crespo, Ana Sofia Rocha, José Carlos Machado, Paula Soares and Manuel Sobrinho-Simões
    Citation: BMC Cancer 2004 4:12
    Content type: Research article Published on:

  34. Fluoropyrimidines such as 5-fluorouracil (5-FU) and 5-fluoro-2'deoxyuridine (FUDR) are among the most effective chemotherapeutic agents for treatment of metastatic colorectal cancer (CRC). Increased expression...

    Authors: Massimo Libra, Patrick M Navolanic, Renato Talamini, Erica Cecchin, Franca Sartor, Salvatore Tumolo, Sara Masier, Salvatore Travali, Mauro Boiocchi and Giuseppe Toffoli
    Citation: BMC Cancer 2004 4:11
    Content type: Research article Published on:

  36. Subtle functional deficiencies in highly conserved DNA repair or growth regulatory processes resulting from polymorphic variation may increase genetic susceptibility to breast cancer. Polymorphisms in DNA repa...

    Authors: Alice J Sigurdson, Michael Hauptmann, Nilanjan Chatterjee, Bruce H Alexander, Michele Morin Doody, Joni L Rutter and Jeffery P Struewing
    Citation: BMC Cancer 2004 4:9
    Content type: Research article Published on:

  40. Carcinoma of uterine cervix is the second most common cancers among women worldwide. Combined radiation and chemotherapy is the choice of treatment for advanced stages of the disease. The prognosis is poor, wi...

    Authors: Pulivarthi H Rao, Hugo Arias-Pulido, Xin-Yan Lu, Charles P Harris, Hernan Vargas, Fang F Zhang, Gopeshwar Narayan, Achim Schneider, Mary Beth Terry and Vundavalli VVS Murty
    Citation: BMC Cancer 2004 4:5
    Content type: Research article Published on:

  41. Carcinogenesis occurs, at least in part, due to the accumulation of mutations in critical genes that control the mechanisms of cell proliferation, differentiation and death. Publicly accessible databases conta...

    Authors: Ping Qiu, Luquan Wang, Mitch Kostich, Wei Ding, Jason S Simon and Jonathan R Greene
    Citation: BMC Cancer 2004 4:4
    Content type: Research article Published on:

  42. A case of Primitive Neuroectodermal Tumor (PNET) of the kidney in a 27-year-old woman is presented. Few cases are reported in the literature with a variable, nonspecific presentation and an aggressive behaviou...

    Authors: Giorgio Pomara, Francesco Cappello, Maria G Cuttano, Francesca Rappa, Girolamo Morelli, Pierantonio Mancini and Cesare Selli
    Citation: BMC Cancer 2004 4:3
    Content type: Case report Published on:

  43. Although sentinel node biopsy (SNB) is becoming the standard approach for axillary staging in patients with small breast cancer, criteria for patient selection and some technical aspects of the procedure have ...

    Authors: Giorgio Zavagno, Gian Luca De Salvo, Dario Casara, Paola Del Bianco, Domenico Rubello, Fabrizio Meggiolaro, Carlo Riccardo Rossi, Mariaelena Pierobon and Mario Lise
    Citation: BMC Cancer 2004 4:2
    Content type: Research article Published on:

  44. Kaposi's sarcoma (KS) is a mesenchymal tumour associated with human herpesvirus-8 infection. However, the incidence of human herpesvirus-8 infection is far higher than the prevalence of KS, suggesting that vir...

    Authors: Thierry Simonart
    Citation: BMC Cancer 2004 4:1
    Content type: Debate Published on:

  45. Dysregulation of apoptosis, specifically overexpression of soluble Fas (sFas), has been proposed to play a role in the development of ovarian cancer. The main objective of the present study was to evaluate ser...

    Authors: Arslan Akhmedkhanov, Eva Lundin, Seth Guller, Annekatrin Lukanova, Andrea Micheli, Yuehong Ma, Yelena Afanasyeva, Anne Zeleniuch-Jacquotte, Vittorio Krogh, Per Lenner, Paola Muti, Sabina Rinaldi, Rudolf Kaaks, Franco Berrino, Göran Hallmans and Paolo Toniolo
    Citation: BMC Cancer 2003 3:33
    Content type: Research article Published on:

  46. Patients with advanced (incurable) tumours usually experience a diverse burden of symptoms. Although many symptom assessment instruments are available, we examined whether these addressed tumour-related symptoms.

    Authors: Margherita J Barresi, Bruce Shadbolt, Don Byrne and Robin Stuart-Harris
    Citation: BMC Cancer 2003 3:32
    Content type: Research article Published on:

  47. Renal cell carcinoma is a common malignancy that often presents as a metastatic-disease for which there are no effective treatments. To gain insights into the mechanism of renal cell carcinogenesis, a number o...

    Authors: Marc E Lenburg, Louis S Liou, Norman P Gerry, Garrett M Frampton, Herbert T Cohen and Michael F Christman
    Citation: BMC Cancer 2003 3:31
    Content type: Research article Published on:

  49. The p53 tumor suppressor gene is commonly mutated in colorectal cancer. While the effect of p53 mutations on colorectal cancer prognosis has been heavily studied, less is known about how epidemiologic risk factor...

    Authors: Mary Beth Terry, Alfred I Neugut, Mahesh Mansukhani, Jerome Waye, Noam Harpaz and Hanina Hibshoosh
    Citation: BMC Cancer 2003 3:29
    Content type: Research article Published on:

  50. Observational studies have consistently shown that aspirin and non-steroidal anti-inflammatory drug (NSAID) use is associated with a close to 50% reduced risk of colorectal cancer. Studies assessing the effect...

    Authors: Antonio González-Pérez, Luis A García Rodríguez and Ruy López-Ridaura
    Citation: BMC Cancer 2003 3:28
    Content type: Research article Published on:

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