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Table 1 Clinical, demographic and immunophenotyping data of the studied groups

From: Emerging roles of ADAM6 and PRSS1 as novel diagnostic/prognostic biomarkers for acute lymphoblastic and myeloid leukemia in adults

Groups/Parameters

Control group

Acute leukemia

ALL group

AML group

N

55

76

36

40

Age (y)

37(26–48)

33(25–44.5)

27.5(22–34.5)

37(26–48)

TLC (k/mm3)

-

16.5(3–60)*

34.5(8–165)*

10.3(2–35.5)*

Hb (g/dl)

-

7.45(6.6–8)*

7.3(6–8)*

7.4(7–8.2)*

Plts (k/mm3)

-

45(22–76)*

44(19.5–72)*

49(22.5–76)*

LDH (IU/l)

-

-

455(235–544)*

-

Uric acid (mg/dl)

-

-

7(5–8)*

-

Blasts in BM after induction chemotherapy (%)

-

-

-

3(2–9)*

CD22 + 

-

-

15

–

-

21

–

CD45 + 

-

-

15

–

-

-

21

–

CD34 + 

-

-

-

26

-

-

-

14

CD117 + 

-

-

-

32

-

-

-

8

HLD-DR + 

-

38

4

34

-

-

38

32

6

ADAM6 (pg/ml)

78.6 (55.8–101.8)

207.9 (162.7–417.8)*

208.7 (178–337)*

186.4 (155–479)*

PRSS1 (ng/ml)

247.5 (204.3–375.3)

175.3 (151.2—217.9)*

175.1 (153.7—232.2)*

177.9 (145.3—206.4)*

  1. Results are expressed as median and interquartile range (IQR)(25 th quartile-75 th quartile),* Significantly different from control (group I) at p > 0.0001
  2. N Number of subjects in each group, TLC Total leukocyte count, hb hemoglobin, plts platelet, LDH Lactate dehydydrogenase, CD Cluster of differentiation, HLA-Dr Human leukocyte death receptor antigen