Evaluation of epigenetic silencing of the miR-139-5p gene in the pathogenesis of colorectal cancer and its diagnostic biomarker capability in plasma samples

Table 2 Relationship between miR−139-5p methylation and clinicopathological specifications in clinical samples of case group

		Tissue PMR	P-value	Plasma PMR	P-value
Clinicopathological characteristic	No. of patients	Mean ± SD^*	P-value	Mean ± SD	P-value
Tumor type
Adenocarcinoma	29	4.19 ± 7.98	0.353^a	17.22 ± 17.13	0.338^a
Mucinous	11	12.89 ± 19.41	0.353^a	21.14 ± 18.22	0.338^a
Histological grading
I	15	5.96 ± 10.07	0.490^c	21.74 ± 19.45	0.583^c
II	21	7.98 ± 15.12		15.15 ± 13.99
III	4	1.61 ± 2.19		21.91 ± 25.87
Tumor location
Distal	13	8.41 ± 17.99	0.732^a	13.03 ± 14.55	0.168^a
Proximal	27	5.71 ± 9.21	0.732^a	20.83 ± 18.17	0.168^a
Tumor size
< 50 mm	21	7.89 ± 14.85	0.390^a	19.70 ± 19.33	0.452^a
\(\geq50\;mm\)	19	5.14 ± 9.62	0.390^a	16.75 ± 15.09	0.452^a
TNM Stage
I	13	4.83 ± 3.69	0.422^b	22.55 ± 16.46	0.348^c
II	19	5.13 ± 9.01		14.47 ± 16.50
III	8	12.91 ± 21.99		20.49 ± 20.52
Lymph node involvement
Yes	8	12.91 ± 21.99	0.209^a	20.49 ± 20.52	0.209^a
No	32	5.01 ± 8.74	0.209^a	17.75 ± 16.71	0.209^a

ISSN: 1471-2407