Fig. 3

Diagnostic value of studied plasma biomarkers using ROC curve analysis shows an excellent AUC, and higher specificity and sensitivity for the plasma miR−139-5p methylated biomarker which is able to detect 75%(sensitivity) of CRC patients and distinguishes 92.5% (specificity) of individuals without CRC a; PMR miR−139-5p (AUC = 0.958, the sensitivity and specificity were 75% and 92.5%, respectively), b; miR-139-5p expression (AUC = 0.767, the sensitivity and specificity were 70% and 65%, in the same order), c; RAP-1b (AUC = 0.718, sensitivity = 73.3%,and specificity = 73.3%), d; CEA (AUC = 0.708, sensitivity = 46.8%,and specificity = 98%)