Causal effect of gut microbiota metabolic pathways on CSAG1 expression in chondrosarcoma: a mendelian randomization analysis

Table 2 Heterogeneity of the Cochran Q test for MR analysis of GMMP on CSAG1

Exposure	Outcome	Method	Cochrane’s Q	Cochrane’s Q df	Cochrane’s Q p-value	I² (%)
ebi-a-GCST90027546	prot-a-677	IVW	36.846	49	0.899	0
ebi-a-GCST90027560	prot-a-677	IVW	41.326	38	0.327	8.048
ebi-a-GCST90027564	prot-a-677	IVW	42.460	51	0.797	0
ebi-a-GCST90027582	prot-a-677	IVW	40.121	43	0.597	0
ebi-a-GCST90027624	prot-a-677	IVW	55.812	55	0.444	1.455
ebi-a-GCST90027631	prot-a-677	IVW	31.131	46	0.954	0
ebi-a-GCST90027646	prot-a-677	IVW	49.633	58	0.775	0

df, the degrees of freedom; MR, mendelian randomization; IVW, Inverse variance weighted
ebi-a-GCST90027546, tetrapyrrole biosynthesis from glutamate
ebi-a-GCST90027560, menaquinol 6 biosynthesis
ebi-a-GCST90027564, glycogen degradation II
ebi-a-GCST90027582, 8 amino 7 oxononanoate biosynthesis
ebi-a-GCST90027624, taxadiene biosynthesis
ebi-a-GCST90027631, glycolysis
ebi-a-GCST90027646, tRNA charging
prot-a-677, CSAG1
The I² statistic was used to reflect the proportion of heterogeneity in the IVs in the total variation. An I² ≤ 0 was set to 0, indicating that no heterogeneity was present; an I² = 0–25% indicated mild heterogeneity

ISSN: 1471-2407