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Table 1 Instrumental variable screening and instrumental variable strength F test for GMMP and CSAG1

From: Causal effect of gut microbiota metabolic pathways on CSAG1 expression in chondrosarcoma: a mendelian randomization analysis

Exposure

Pathway

Number of SNPs

Median of F

Minimum of F

Maximum of F

ebi-a-GCST90027546

Tetrapyrrole biosynthesis from glutamate

50

17.75675

16.47309

25.0195

ebi-a-GCST90027560

Menaquinol 6 biosynthesis

39

18.06635

16.45589

22.64702

ebi-a-GCST90027564

Glycogen degradation II

52

17.77527

16.52922

22.00014

ebi-a-GCST90027582

8 amino 7 oxononanoate biosynthesis

44

17.7721

16.49744

23.24438

ebi-a-GCST90027624

Taxadiene biosynthesis

56

17.78317

16.50707

24.11524

ebi-a-GCST90027631

glycolysis

47

18.31713

16.44694

25.12113

ebi-a-GCST90027646

tRNA charging

59

17.84809

16.52766

29.64234

  1. The robustness of the selected instrumental variables was proved by F test
  2. SNP, single nucleotide polymorphism
  3. ebi-a-GCST90027546, tetrapyrrole biosynthesis from glutamate
  4. ebi-a-GCST90027560, menaquinol 6 biosynthesis
  5. ebi-a-GCST90027564, glycogen degradation II
  6. ebi-a-GCST90027582, 8 amino 7 oxononanoate biosynthesis
  7. ebi-a-GCST90027624, taxadiene biosynthesis
  8. ebi-a-GCST90027631, glycolysis
  9. ebi-a-GCST90027646, tRNA charging