Preoperative plasma cell-free DNA chromosomal instability predicts microvascular invasion in hepatocellular carcinoma: a prospective study

Table 3 Performance of Z-score of all chromosomes, CIN scores, TFx, UCAD and AFP for MVI prediction in HCC patients

	AUC (95%CI)	Cutoff	TN	TP	FN	FP	Sensitivity	Specificity	NPV	PPV	Accuracy
Z-score of all chromosomes	0.637 (0.503–0.77)	\|Z\|>2.26	34	11	5	24	0.688	0.586	0.872	0.314	0.608
CIN score	0.702 (0.612–0.79)	> 693.19	27	15	1	31	0.938	0.466	0.964	0.326	0.568
TFx	0.64 (0.503–0.777)	> 0.07	38	11	5	20	0.625	0.656	0.863	0.355	0.649
UCAD	0.749 (0.635–0.863)	> 0.199	27	15	1	31	0.938	0.466	0.964	0.326	0.568
AFP	0.565 (0.438–0.691)	< 20	22	12	4	36	0.75	0.379	0.846	0.25	0.459

Abbreviations: UCAD = CIN score + TFx + Z-score of all chromosomes; The predictive performance of the UCAD by combination all chromosomal aberrations; sensitivity = TP/(TP + FN), specificity = TN/(TN + FP), NPV = TN/(TN + FN), PPV = TP/(TP + FP), (TN + TP)/(TN + FN + TP + FP). AFP, alpha fetoprotein; AUC, area under curve; CIN, chromosomal instability; HCC, hepatocellular carcinoma; TFx, fraction derived from tumor cells; FN, false negative; FP, false true positive; MVI, microvascular invasion; NPV, negative predictive value; PPV, positive predictive value; TN, true negative; TP, true positive

ISSN: 1471-2407