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Fig. 7 | BMC Cancer

Fig. 7

From: INHBA+ macrophages and Pro-inflammatory CAFs are associated with distinctive immunosuppressive tumor microenvironment in submucous Fibrosis-Derived oral squamous cell carcinoma

Fig. 7

Graphical illustration of the working model. In ODSCC, upregulated INHBA mediates crosstalk between INHBA+Mac and iCAF via the INHBA-ACVR1/ACVR2A/ACVR2B ligand-receptor axis, activating the SMAD signaling pathway to induce Treg differentiation and functionally exert immunosuppressive activity

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BMC Cancer

ISSN: 1471-2407

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