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Fig. 6 | BMC Cancer

Fig. 6

From: INHBA+ macrophages and Pro-inflammatory CAFs are associated with distinctive immunosuppressive tumor microenvironment in submucous Fibrosis-Derived oral squamous cell carcinoma

Fig. 6

INHBA is involved in the modulation effect of INHBA+Mac and iCAF on Treg through the SMAD pathway in ODSCC. (A) Mountain plot of the expression of INHBA in different cell subsets in ODSCC and NODSCC.(B) mIFC demonstrating a higher expression of INHBA in ODSCC than NODSCC. (C) Bar chart of the relationship between different concentrations of arecoline stimulation and TGF(Left)/ INHBA (Right) expression in macrophages. (D) Spatial transcriptomics analysis of the overlapping area of INHBA-ACVR1/ACVR2A/ACVR2B and iCAF/Tregs/INHBA+Mac. (E) mIFC confirmed that the distribution of Tregs (CD4 + FOXP3+) is correlated with INHBA (left). (F) Statistical graph showing the spatial distribution of Treg around INHBA. (G) GSEA analysis of SMAD2/3-related signaling pathways in Tregs. (H) Mountain plot of the expression distribution of TGFβ superfamily members in two groups. (I) Heatmap of the expression distribution of the receptor of INHBA in different cell types of CD4 + T cells

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BMC Cancer

ISSN: 1471-2407

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