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Fig. 5 | BMC Cancer

Fig. 5

From: INHBA+ macrophages and Pro-inflammatory CAFs are associated with distinctive immunosuppressive tumor microenvironment in submucous Fibrosis-Derived oral squamous cell carcinoma

Fig. 5

iCAF significantly increased and possessed stronger immune-suppressive functions in ODSCC. (A) t-SNE dimensionality reduction-categorized 4 subtypes of CAFs. (B) Heatmap showing TOP 5 markers in indicated CAF subclusters (C) Tissue distribution of CAF subclusters in each group. (D) Bubble plot of representative GO pathways enrichment in CAF subclusters predicted by GSVA. (E) Volcano plot of differentially expressed genes between NODSCC and ODSCC groups in CAFs. (F) The regulation of T cells and macrophages by iCAF through immune-suppressive signals. (G) Pseudotime analysis of CAFs (cell types, pseudotime)

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BMC Cancer

ISSN: 1471-2407

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