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Fig. 2 | BMC Cancer

Fig. 2

From: INHBA+ macrophages and Pro-inflammatory CAFs are associated with distinctive immunosuppressive tumor microenvironment in submucous Fibrosis-Derived oral squamous cell carcinoma

Fig. 2

T cells in ODSCC exhibit a more severe immunosuppressive landscape. (A) Distribution of T cells in ODSCC and NODSCC revealed by spatial transcriptomics data. (B) t-SNE of major subclusters of T cells. (C) Tissue distribution of major T cell subtypes in each group. (D) Further dimensionality reduction and clustering-categorized CD8 + Tex cells into Tterm and Tprog subtypes. (E) Heatmap comparing the expression of marker genes associated with T cell exhaustion in Tterm between ODSCC and NODSCC. (F) Violin plot comparing the expression of marker genes associated with T cell exhaustion in Tterm between ODSCC and NODSCC. (G) Tissue distribution of CD8 + T subsets. (H, I) Heatmap illustrating the differences in MHC-I signaling regulation between ODSCC (H) and NODSCC (I). mIFC demonstrating a higher prevalence of exhausted T cells in ODSCC than NODSCC. (J) mIFC demonstrating a higher prevalence of exhausted T cells in ODSCC than NODSCC. (K) Spatial feature plots of the signatures of CD8 + Tex in ODSCC and NODSCC tissue sections

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BMC Cancer

ISSN: 1471-2407

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