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Table 7 Univariate and multivariate COX regression analysis for the parameters affecting overall free survival for different parameters

From: Prognostic and diagnostic value of PVR gene and protein levels, serum amylase, and urinary IGFBP-7 and TIMP-2 biomarkers in multiple myeloma

 

Univariate

#Multivariate

p-value

HR (LL – UL 95% CI)

p-value

HR (LL – UL 95%C.I)

Sex

0.449

2.398(0.249 – 23.063)

  

Age (years)

0.193

1.147(0.933 – 1.409)

  

eGFR

0.153

0.816(0.617 – 1.078)

  

Creatinine

0.033*

5.254(1.145 – 24.113)

0.421

68.435 (0.002 – 2035606.03)

Albumin

0.228

0.037(0.0 – 7.972)

  

B2 microglobulin

0.057

5.587(0.952 – 32.777)

  

TLC

0.264

0.387(0.073 – 2.047)

  

Hb

0.467

0.726(0.306 – 1.721)

  

PLT

0.632

0.994(0.972 – 1.017)

  

LDH

0.597

0.993(0.965 – 1.020)

  

Plasma cell%

0.012*

2.164(1.186 – 3.947)

0.172

10.330(0.363 – 293.613)

PVR gene expression (High)

0.041*

66.22 (1.07– 20451.0)

0.042*

12.2 (1.03-361.2)

PVR serum level (High)

0.319

3.161(0.329 – 30.395)

  

Serum amylase (High)

0.029*

66.037(1.264– 204334.0)

0.038*

11.5 (1.36-41.6)

IGFBP-7 (High)

0.032*

69.224(1.106– 216216.3)

0.041*

11.9 (2.13-321.6)

TIMP-2 (High)

0.781

21.448(0–52204660537.97)

  
  1. HR Hazard ratio, C.I Confidence interval, LL Lower limit, UL Upper Limit
  2. #All variables with p<0.05 were included in the multivariate
  3. *Statistically significant at p ≤ 0.05