Prognostic and diagnostic value of PVR gene and protein levels, serum amylase, and urinary IGFBP-7 and TIMP-2 biomarkers in multiple myeloma

Table 4 Kaplan–Meier survival curves for PFS according to different parameters

Parameter	Low expression			High expression			Log rank		Adjusted p-value (Bonferroni)
Parameter	Mean	Median	% End of Study	Mean	Median	% End of Study	χ2	p Value	Adjusted p-value (Bonferroni)
PVR Gene Expression	40.29	39.0	40.5%	40.96	49.0	9.2%	1.415	0.234	1.000
PVR Serum Level	45.35	52.0	27.7%	38.70	44.0	0.0%	2.970	0.085	0.680
Serum Amylase	41.369	39.0	0.0%	40.525	48.0	9.3%	0.727	0.394	1.000
IGFBP-7	46.691	51.0	22.5%	37.449	42.0	0.0%	7.820*	0.005*	0.040*
TIMP-2	29.0	9.0	50.0%	42.211	48.0	7.8%	0.0	0.986	1.000

^*Significant adjusted p-value. Bonferroni correction applied for 8 survival comparisons (adjusted α = 0.00625)

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