Prognostic and diagnostic value of PVR gene and protein levels, serum amylase, and urinary IGFBP-7 and TIMP-2 biomarkers in multiple myeloma

Table 12 Multiple testing correction outcomes

Analysis Type	Comparison	Raw p-value	Adjusted p/q	Method	Significant (Y/N)	Effect Size
Primary Survival	PVR expression vs OS	0.001	0.008	Bonferroni	Y	HR=3.1
Primary Survival	Serum amylase vs PFS	0.004	0.032	Bonferroni	Y	HR=2.3
Correlation	PVR vs β2M	0.008	0.042	FDR	Y	r=0.52
Correlation	IGFBP7 vs eGFR	0.018	0.088	FDR	N	r=−0.45
ROC Analysis	PVR gene expression	<0.001	0.004	Bonferroni	Y	AUC=0.92

Statistical testing outcomes after multiple comparison correction. Primary analyses used Bonferroni correction (α=0.006), and exploratory analyses used FDR control (q<0.05). HR Hazard Ratio, AUC Area Under Curve

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