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Table 1 Clinical characteristics of multiple myeloma cases and controls (n=100)

From: Prognostic and diagnostic value of PVR gene and protein levels, serum amylase, and urinary IGFBP-7 and TIMP-2 biomarkers in multiple myeloma

 

Cases (n = 50)

Control (n = 50)

Test of significance

p-value

Sex

 Male

23 (46.0%)

27 (54.0%)

χ2= 0.640

0.424

 Female

27 (54.0%)

23 (46.0%)

  

 Age (years)

  

t= 2.193

0.31

 Mean ± SD

68.7 ± 5.26

66.3 ± 5.41

  

 Median (Min. – Max.)

68.5 (60.0–79.0)

64.0 (58.0–76.0)

  

eGFR

 <60

32 (64.0%)

0 (0.0%)

χ2= 47.059*

<0.001*

 >60

18 (36.0%)

50 (100.0%)

  

 Mean ± SD.

39.8 ± 26.6

80.7 ± 3.6

U= 167.0

<0.001*

 Median (Min. – Max.)

34.8 (7.9–90.6)

80.5 (74.0–86.0)

  

Creatinine

 Mean ± SD.

2.3 ± 1.4

0.9–0.2

U= 294.500*

<0.001*

 Median (Min. – Max.)

2.0 (0.70–5.0)

0.9 (0.50–1.20)

  

Albumin

 Mean ± SD.

3.5 ± 0.7

4.3 ± 0.5

U= 386.500*

<0.001*

 Median (Min. – Max.)

3.1 (2.7–5.1)

4.3 (3.5–5.0)

  

LDH

 Mean ± SD.

356.3 ± 35.2

347.0 ± 49.1

t= 9.091

0.027*

 Median (Min. – Max.)

463.5 (289.0–510.0)

350.0 (256.0–450.0)

  

 β2 microglobulin

  

U= 119.000*

<0.001*

 Mean ± SD.

5.1 ± 1.5

2.7 ± 4.0

  

 Median (Min. – Max.)

5.4 (2.7–7.4)

2.0 (1.0–22.0)

  

TLC

 Mean ± SD.

4.9 ± 0.8

7.7 ± 2.2

U= 349.000*

<0.001*

 Median (Min. – Max.)

4.8 (3.8–7.0)

8.1 (4.6–11.0)

  

Hb

 Mean ± SD.

11.0 ± 12.5

12.8 ± 0.9

t= 0.994

0.325

 Median (Min. – Max.)

8.0 (6.5–71.0)

13.0 (11.5–14.0)

  

PLT

 Mean ± SD.

175.7 ± 37.2

285.5 ± 83.3

t= 8.504*

<0.001*

 Median (Min. – Max.)

166.0 (15.0–256.0)

270.0 (165.0–450.0)

  

Plasma cell %

 Mean ± SD.

32.0 ± 13.6

4.8 ± 2.1

U= 0.000

<0.001*

 Median (Min. – Max.)

27.5 (13.0–55.0)

5.0 (1.0–8.0)

  

PVR gene expression

 Mean ± SD.

2.9 ± 2.1

1.0 ± 0.0

U= 850.000*

0.003*

 Median (Min. – Max.)

3.0 (0.2–5.6)

1.0 (1.0–1.0)

  

PVR serum level ng/mL

 Mean ± SD.

124.2 ± 4.8

1.8 ± 0.4

t= 179.755*

<0.001*

 Median (Min. – Max.)

124.0 (116.0–133.0)

1.7 (1.1–2.6)

  

Serum amylase U/L

 Mean ± SD.

168.6 ± 35.0

36.5 ± 7.9

t= 26.016*

<0.001*

 Median (Min. – Max.)

164.5 (112.0–265.0)

35.0 (25.0–55.0)

  

IGFBp7/creatinine

 Mean ± SD.

0.703 ± 0.520

0.093 ± 0.240

U=227.0*

<0.001*

 Median (Min. – Max.)

0.633 (0.002–2.066)

0.062(0.002–1.750)

  

TIMP2/creatinine

 Mean ± SD.

0.147 ± 0.123

0.029 ± 0.065

U=277.0*

<0.001*

 Median (Min. – Max.)

0.115 (0.005–0.444)

0.017(0.006–0.433)

  
  1. SD Standard deviation, t Student t-test, U Mann Whitney test, χ2 Chi-square test
  2. *Statistically significant at p ≤ 0.05
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BMC Cancer

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