Fig. 1

Single-cell characterization of glutamine metabolic heterogeneity in MM. (A) Heatmap of cluster-defining marker genes across six clusters transcriptional subgroups. (B) t-SNE projection demonstrating B-cell/plasma cell identity via SingleR annotation. (C) GM-AUCell scoring distribution of glutamine metabolic activity. (D) Bimodal stratification into high/low metabolic subgroups (median cutoff)