Skip to main content

Table 2 Univariate and multivariate analyses of PFS in the NACT cohort

From: Patients with macroscopic lymph node metastasis expect poor prognosis after neoadjuvant chemotherapy in advanced ovarian cancer: a retrospective cohort study based on a single gynecological team

Characteristics

Univariate

Multivariate

HR (95% CI)

P value

HR (95% CI)

P value

Age

1.00 (0.978–1.02)

0.960

1.00 (0.973–1.04)

0.763

BMI

1.01 (0.944–1.07)

0.849

  

CCI

 0

Ref

   

 1

0.51 (0.185–1.38)

0.184

  

  ≥ 2

1.09 (0.501–2.37)

0.829

  

Hydrothorax

 No

Ref

   

 Yes

1.13 (0.566–2.27)

0.723

  

Ascites

 No

Ref

 

Ref

 

 Yes

0.857 (0.557–1.32)

0.483

0.806 (0.456–1.42)

0.458

CA125

1.00 (1.00–1.00)

0.959

  

BRCA mutationa

 No

Ref

 

Ref

 

 Yes

0.459 (0.246–0.856)

0.0143

0.516 (0.273–0.975)

0.042

FIGO stage

 IIIC

Ref

 

Ref

 

 IV

1.08 (0.684–1.70)

0.750

0.665 (0.349–1.27)

0.214

SCS

 LOW

Ref

   

 Non-LOWb

1.10 (0.651–1.85)

0.726

  

NACT cycles

  ≤ 2

Ref

   

 3

1.25 (0.788–1.97)

0.346

  

  ≥ 4

1.28 (0.641–2.56)

0.483

  

LN status

 NLN

Ref

 

Ref

 

 MLN

1.84 (1.20–2.82)

0.00519

1.90 (1.06–3.41)

0.032

  1. aPatients with unknown BRCA mutation status were not included
  2. bThe intermediate and high IDS levels were combined because only 4 patients underwent IDS at high levels