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Table 3 Predictive ability of biomarkers for any grade of RE (Grade ≥ 1) and grade 3 on univariate and multivariate analyses

From: Detecting radiation esophagitis using 18F-FAPI-04 PET/CT in patients with LA-ESCC treated with concurrent chemoradiotherapy

Patients

RE of any grade (Grade ≥ 1)

 

Grade 3 RE

n = 30

Univariate

Multivariate

 

Univariate

Multivariate

Variable

OR (95%CI)

P

value

OR (95%CI)

P

value

 

OR (95%CI)

P

value

OR (95%CI)

P

value

ECOG score

2.63

(0.44–15.78)

0.292

-

-

 

2.00

(0.33–12.24)

0.453

-

-

V50*

1.08

(0.98–1.19)

0.108

1.01

(0.91–1.12)

0.904

 

1.07 (0.98–1.17)

0.146

1.02

(0.89–1.16)

0.838

V60

1.03

(0.96–1.11)

0.386

-

-

 

1.01

(0.94–1.09)

0.806

-

-

RT dose (Gy)

1.06

(0.89–1.27)

0.527

-

-

 

1.00

(0.81–1.22)

0.967

-

-

TBRblood

         

 During-RT*

2.86

(1.18–6.89)

0.020

-

-

 

2.09

(1.11–3.92)

0.022

-

-

 △TBRblood*

3.08

(1.20–7.90)

0.019

3.06

(1.18–7.89)

0.021

 

2.10

(1.12–3.95)

0.022

2.03

(1.04–3.97)

0.038

  1. *P < 0.2
  2. △TBRblood = TBRblood (during-RT)– TBRblood (Pre-RT)
  3. Abbreviations: RE: radiation esophagitis; OR: odds ratio; 95% CI: 95% confidence interval; ECOG: Eastern Cooperative Oncology Group; V50: volume of esophagus receiving ≥ 50 Gy; V60: volume of esophagus receiving ≥ 60 Gy; RT: radiotherapy
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BMC Cancer

ISSN: 1471-2407

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