Table 4 Characteristic of CEUS of molecular subtype groups

Time of appearance

9.00(7.00,10.00)

9.00(8.00,11.00)

8.00(7.00,9.75)

9.00(7.50,10.50)

8.50(7.00,9.00)

Time of peak

15.00(13.00,18.00)

16.00(14.00,18.00)

15.00(13.00,17.00)

16.00(14.00,18.50)

15.00(13.25,16.75)

Time from appearance to peak

7.00(6.00,8.00)

6.00(5.25,8.00)

7.00(6.00,8.00)

7.00(6.00,8.00)

7.00(6.00,8.75)

Time of fading

40.00(34.00,49.00)

37.00(31.25,47.75)

40.50(34.25,51.75)

40.00(37.50,47.50)

36.00(30.25,47.25)

Enhancement border

 Clear

64 (41%)

16 (33%)

28 (44%)

15 (56%)

5 (28%)

 Unclear

93 (59%)

32 (67%)

36 (56%)

12 (44%)

13 (72%)

Enhancement pattern

 Irregular

133 (85%)

41 (85%)

55 (86%)

21 (78%)

16 (89%)

 Regular

24 (15%)

7 (15%)

9 (14%)

6 (22%)

2 (11%)

Enhancement distribution

 Heterogeneous

118 (75%)

32 (67%)

49 (77%)

22 (81%)

15 (83%)

 Homogeneous

38 (24%)

16 (33%)

14 (22%)

5 (19%)

3 (17%)

Enhancement intensity

 High

138 (88%)

40 (83%)

56 (88%)

24 (89%)

18 (100%)

 Low

2 (1.3%)

1 (2.1%)

1 (1.6%)

0 (0%)

0 (0%)

 None

4 (2.5%)

2 (4.2%)

2 (3.1%)

0 (0%)

0 (0%)

 Normal

13 (8.3%)

5 (10%)

5 (7.8%)

3 (11%)

0 (0%)

Enhancement direction

 Centrifugal

15 (9.6%)

6 (13%)

6 (9.4%)

2 (7.4%)

1 (5.6%)

 Centripetal

116 (74%)

35 (73%)

47 (73%)

19 (70%)

15 (83%)

 Diffuse

22 (14%)

5 (10%)

9 (14%)

6 (22%)

2 (11%)

Perfusion defects

77 (49%)

23 (48%)

33 (52%)

10 (37%)

11 (61%)

Crab-claw-like pattern

62 (39%)

18 (38%)

25 (39%)

12 (44%)

7 (39%)

Enhancement area

 Equal

34 (22%)

12 (25%)

14 (22%)

6 (22%)

2 (11%)

 Larger

123 (78%)

36 (75%)

50 (78%)

21 (78%)

16 (89%)

Enhancement time

 Delayed

11 (7.0%)

4 (8.3%)

6 (9.4%)

0 (0%)

1 (5.6%)

 Early

88 (56%)

28 (58%)

33 (52%)

17 (63%)

10 (56%)

 Synchronous

58 (37%)

16 (33%)

25 (39%)

10 (37%)

7 (39%)

Rapid enhancement

122 (78%)

40 (83%)

47 (73%)

21 (78%)

14 (78%)

Rapid fading

80 (51%)

29 (60%)

31 (48%)

14 (52%)

6 (33%)

BI

2.16(0.99,3.49)

2.01(0.95,3.57)

2.01(1.00,3.24)

2.64(1.00,5.58)

2.46(1.21,5.35)

AT

8.28(6.50,9.80)

8.33(7.29,10.26)

7.91(6.20,9.65)

8.50(7.68,9.87)

7.80(6.78,9.52)

TTP

16.50(13.51,20.01)

16.65(13.50,22.42)

16.50(13.62,19.75)

16.56(13.93,19.83)

14.93(12.80,17.78)

PI

26.99(21.83,32.76)

26.54(21.47,30.64)

25.75(19.94,30.53)

32.16(24.46,35.77)

29.25(25.04,33.13)

AS

0.65(0.52,0.84)

0.63(0.49,0.89)

0.66(0.53,0.83)

0.65(0.49,0.79)

0.71(0.58,0.83)

DT/2

91.91(75.60,115.03)

85.65(66.35,104.77)

93.60(78.80,118.00)

107.30(88.40,122.75)

80.36(75.62,105.23)

DS

-0.13(-0.18,-0.10)

-0.14(-0.20,-0.11)

-0.13(-0.18,-0.10)

-0.12(-0.17,-0.10)

-0.15(-0.17,-0.11)

AUTIC

1,680.37(1,102.60,2,131.93)

1,535.61(1,063.06,1,956.72)

1,569.23(1,058.75,2,056.55)

1,912.24(1,548.84,2,268.58)

1,641.23(1,295.87,2,114.50)

MTT

85.80(67.78,105.34)

80.37(60.26,99.40)

86.10(69.30,106.12)

97.15(77.30,114.66)

70.84(68.45,98.35)