Table 3 Univariate and multivariate Cox analysis for the clinical model

P value

HR

95%CI

P value

HR

95%CI

Gender

Male vs. female

0.125

0.357

0.096 ~ 1.332

Age

<60 vs. ≥60

0.420

0.618

0.192 ~ 1.990

BMI

BMI<25 vs. BMI ≥ 25

0.192

0.258

0.033 ~ 1.981

ECOG PS

ECOG = 0 vs. ECOG = 1

0.387

0.041

0.000 ~ 57.381

Tumor location

Cervical vs. thoracic and abdominal

0.976

1.016

0.343 ~ 3.013

Pathological grading

Well vs. others

0.684

0.909

0.573 ~ 1.441

Number of organs with metastases

Organ = 1 vs. Organs>1

0.074

1.616

0.954 ~ 2.735

History of radiotherapy

No vs. Yes

0.120

2.322

0.803 ~ 6.714

History of primary lesion surgery

No vs. Yes

0.600

1.330

0.458 ~ 3.858

History of targeted drug therapy

NO vs. YES

0.663

0.636

0.083 ~ 4.877

Maximum change in target lesion diameter

<0% vs.≥0%

0.934

1.066

0.238 ~ 4.770

CEA (ng/mL)

CEA <5 vs. CEA ≥ 5

0.348

1.854

0.511 ~ 6.730

AST (IU/L)

AST < 40 vs. AST ≥ 37

0.026

23.475

1.469 ~ 375.680

ALT (IU/L)

ALT < 41 vs. ALT ≥ 41

0.054

22.060

0.001 ~ 501,589

LDH (IU/L)

LDH < 250 vs. LDH ≥ 250

0.006

6.387

1.682 ~ 24.250

0.013

6.780

1.500 ~ 30.800

ALP (IU/L)

ALP < 129 vs. ALP ≥ 129

0.469

1.742

0.388 ~ 7.824

UA (umol/L)

UA < 428 vs. UA ≥ 428

0.583

0.565

0.071 ~ 4.334

ALB (g/L)

ALB < 40 vs. ALB ≥ 40

0.697

0.810

0.280 ~ 2.340

DBIL (umol/L)

DBIL < 6 vs. DBIL ≥ 6

0.688

0.770

0.214 ~ 2.768

IBIL (umol/L)

IBIL < 17 vs. IBIL ≥ 17

0.046

11.490

1.042 ~ 126.760

0.012

39.590

2.220 ~ 704.0