Table 2 Adverse events
Adverse events, n (%) | Any grade | Grade I | Grade II | Grade III | Grade IV |
|---|---|---|---|---|---|
Leukopenia | 31 (52.5) | 11 (18.6) | 14 (23.7) | 3 (5.1) | 3 (5.1) |
Fatigue | 15 (25.4) | 12 (20.3) | 2 (3.4) | 1 (1.7) | 0 (0.0) |
Anemia | 14 (23.7) | 10 (16.9) | 4 (6.8) | 0 (0.0) | 0 (0.0) |
Thrombocytopenia | 14 (23.7) | 8 (13.6) | 4 (6.8) | 2 (3.4) | 0 (0.0) |
Neutropenia | 13 (22.0) | 6 (10.2) | 5 (8.5) | 1 (1.7) | 1 (1.7) |
Hypoalbuminemia | 13 (22.0) | 13 (22.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Myelosuppression | 12 (20.3) | 1 (1.7) | 9 (15.3) | 0 (0.0) | 2 (3.4) |
Loss of appetite | 10 (16.9) | 6 (10.2) | 3 (5.1) | 1 (1.7) | 0 (0.0) |
Erythropenia | 10 (16.9) | 5 (8.5) | 3 (5.1) | 0 (0.0) | 2 (3.4) |
Digestive tract reaction | 8 (13.6) | 6 (10.2) | 2 (3.4) | 0 (0.0) | 0 (0.0) |
Increased TBIL | 8 (13.6) | 6 (10.2) | 2 (3.4) | 0 (0.0) | 0 (0.0) |
Diarrhea | 8 (13.6) | 3 (5.1) | 2 (3.4) | 3 (5.1) | 0 (0.0) |
Liver dysfunction | 7 (11.9) | 4 (6.8) | 3 (5.1) | 0 (0.0) | 0 (0.0) |
Increased AST | 6 (10.2) | 4 (6.8) | 2 (3.4) | 0 (0.0) | 0 (0.0) |
RCCEP | 5 (8.5) | 5 (8.5) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Increased ALT | 5 (8.5) | 4 (6.8) | 1 (1.7) | 0 (0.0) | 0 (0.0) |
Lymphopenia | 5 (8.5) | 4 (6.8) | 1 (1.7) | 0 (0.0) | 0 (0.0) |
Weight loss | 5 (8.5) | 4 (6.8) | 1 (1.7) | 0 (0.0) | 0 (0.0) |
Increased blood pressure | 4 (6.8) | 2 (3.4) | 2 (3.4) | 0 (0.0) | 0 (0.0) |
Hand-foot skin reaction | 4 (6.8) | 2 (3.4) | 1 (1.7) | 1 (1.7) | 0 (0.0) |
Nausea and vomiting | 3 (5.1) | 1 (1.7) | 2 (3.4) | 0 (0.0) | 0 (0.0) |
Increased Cr | 3 (5.1) | 3 (5.1) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Hypocalcemia | 2 (3.4) | 2 (3.4) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Hypothyroidism | 2 (3.4) | 1 (1.7) | 1 (1.7) | 0 (0.0) | 0 (0.0) |
Fever | 2 (3.4) | 2 (3.4) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Sore throat | 1 (1.7) | 1 (1.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Gastrointestinal bleeding | 2 (3.4) | 0 (0.0) | 2 (3.4) | 0 (0.0) | 0 (0.0) |
Hemoptysis | 1 (1.7) | 1 (1.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Oral mucosal inflammation | 1 (1.7) | 0 (0.0) | 1 (1.7) | 0 (0.0) | 0 (0.0) |
Immune enteritis | 1 (1.7) | 0 (0.0) | 1 (1.7) | 0 (0.0) | 0 (0.0) |
Pain | 1 (1.7) | 0 (0.0) | 1 (1.7) | 0 (0.0) | 0 (0.0) |
Atrial fibrillation | 1 (1.7) | 0 (0.0) | 0 (0.0) | 1 (1.7) | 0 (0.0) |