Fig. 6

Biological enrichment analysis. Notes: A: DEGs analysis was performed in patients with high and low HOXB8 expression, 77 downregulated and 431 upregulated; B: ClueGO analysis of these DEGs; C: ssGSEA analysis was used to identify the correlation between specific pathways and HOXB8; D: GSEA analysis based on Hallmark gene set; E-G: GSEA analysis based on KEGG gene set; E: Western blot was used to detect the key protein involved in PI3K/AKT/mTOR and EMT signaling in the sh#ctl and sh#HOXB8 cells (SCC-4 cells)