The causal relationships between mitochondria and six types of cancer: a Mendelian randomization study

Tang, Jincheng; Zhang, Jingting; Yang, Renyi; Chen, Hongyao; Yu, Xiaopeng; Peng, Wei; Zeng, Puhua

doi:10.1186/s12885-025-14201-0

BMC Cancer

Table 2 The results of the Cochran Q test, Egger intercept test, and Steiger test were used to assess the causal relationship between mitochondria and six types of cancer

From: The causal relationships between mitochondria and six types of cancer: a Mendelian randomization study

Outcome	Exposure	Cochran Q test P value	MR-Egger intercept test P value	Steiger test P value
Hepatic cancer	39 S ribosomal protein L34, mitochondrial	0.497	0.629	0.187
	Mitochondrial fission regulator 1	0.957	0.665	0.224
	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	0.338	0.751	0.349
	Steroidogenic acute regulatory protein, mitochondrial	0.515	0.056	0.064
	Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial	0.934	0.713	< 0.001
	Mitochondrial import inner membrane translocase subunit TIM14	0.302	0.929	0.154
Colorectal cancer	Phenylalanine-tRNA ligase, mitochondrial	0.440	0.824	0.029
	Methylmalonyl-CoA epimerase, mitochondrial	0.209	0.073	0.163
	Malonyl-CoA decarboxylase, mitochondrial	0.041	0.414	0.186
	Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial	0.747	0.796	< 0.001
	Mitochondrial import inner membrane translocase subunit TIM14	0.235	0.648	0.154
Lung cancer	Superoxide dismutase [Mn], mitochondrial levels	0.683	0.967	0.014
Lung cancer	Succinate dehydrogenase assembly factor 2, mitochondrial	0.800	0.329	0.247
Esophageal cancer	Lon protease homolog, mitochondrial	0.886	0.681	0.007
Thyroid cancer	Iron-sulfur cluster assembly enzyme ISCU, mitochondrial	0.787	0.737	0.168
	Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial	0.671	0.871	< 0.001
	Diablo homolog, mitochondrial	0.657	0.723	0.076
	Persulfide dioxygenase ETHE1, mitochondrial	0.299	0.114	0.072
Breast cancer	39 S ribosomal protein L34, mitochondrial	0.869	0.984	0.188
	ADP-ribose pyrophosphatase, mitochondrial	0.609	0.810	< 0.001
	Pyruvate carboxylase, mitochondrial	0.888	0.505	0.144
	rRNA methyltransferase 3, mitochondrial	0.640	0.641	< 0.001
	Cytochrome c oxidase assembly factor 3 homolog, mitochondrial	0.638	0.505	0.097
	Cytochrome c oxidase subunit 8 A, mitochondrial	0.940	0.428	< 0.001

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ISSN: 1471-2407

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