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Fig. 5 | BMC Cancer

Fig. 5

From: ATP6V0B promotes the tumorigenesis of bladder cancer by activating PAQR4/PI3K/AKT signaling

Fig. 5

ATP6V0B upregulated the expression of PAQR4 in BCa. (A) The Venn diagram shows that there are 54 genes that are positively correlated with ATP6V0B and upregulated in BCa, and among these 54 genes, 15 genes have significantly different survival curves. (B - D) The GEPIA database was used to analyze the correlation between ATP6V0B and PAQR4 (B), the level of PAQR4 mRNA (C), and overall survival, as determined by the level of PAQR4 mRNA (D). (E) The K-M plotter was used to validate the overall survival of PAQR4. (F) RT-qPCR analysis was performed to evaluate the level of PAQR4 mRNA in BCa tumor tissues and adjacent normal tissues (n = 30). (G) The correlation between ATP6V0B and PAQR4 was analyzed based on the level of mRNA of ATP6V0B and PAQR4. (H) BCa cells were transfected with the indicated plasmids, and RT-qPCR analysis was performed to evaluate the level of PAQR4 mRNA 36 h after transfection. (I) Western blotting analysis was performed to measure the expression of PAQR4 48 h after transfection; *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001

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BMC Cancer

ISSN: 1471-2407

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