Fig. 7

Genomic alterations and TMB analysis in high- and low-risk HNSCC patients. Mutation landscape of the low-risk (a) and high-risk (b) groups, showing the frequency and distribution of somatic mutations in HNSCC patients. Comparison of significantly mutated genes between the low-risk and high-risk groups (c). Violin plot comparing TMB levels between the low-risk and high-risk groups (d). Kaplan–Meier survival analysis of HNSCC patients stratified by TMB (e). Kaplan–Meier survival analysis of HNSCC patients stratified by both TMB status and risk score (f). Abbreviations: TMB, tumor mutation burden; HNSCC, head and neck squamous cell carcinoma; OR, odds ratio; CI, confidence interval. Statistical significance: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns: not significant