Fig. 6

PRDX1 knockdown inhibits DLBCL xenograft tumor growth. A. Tumor formation in mice injected with OCI-Ly3 cells stably transduced with the lv-PRDX1 or lv-NC vectors was observed (n = 6). B. Tumor weight change and tumor growth curve after PRDX1 Knockdown. C-D. The immunohistochemistry assay was conducted to measure the expression of GPX4 (Magnification: 400×, Scale: 100 μm) and ki67 (Magnification: 400×, Scale: 100 μm) in tumor samples in the lv-NC group and lv-PRDX1 group. E. The protein expression levels of GPX4 and SCL7A11 in DLBCL cells were measured using western blot. F. Western blot analysis was conducted to measure the protein levels of p-ERK and ERK. ^**P < 0.01 vs. lv-NC group