Fig. 2

Safety signals (ROR) of combination therapy (pembrolizumab + pemetrexed + platinum) and chemotherapy alone (pemetrexed + platinum) were compared at the SOC level. The confidence interval to the right of the null effect line (ROR = 1) indicates a higher risk of adverse events in the combination therapy group. Abbreviations: SOC, system organ class; PPP, pemetrexed and platinum with pembrolizumab; PP, pemetrexed and platinum; ROR, reporting odds ratio; CI, confidence interval