Fig. 1

Exposure was modeled considering (A) Fixed exposure (use or non-use) both pre-diagnosis (≤ 6 months prior to diagnosis) and baseline post-diagnosis (> 30 days and ≤ 305 days (10 months) following diagnosis); and (B) updated post-diagnosis exposure over follow-up considering never, current, and past use and updated cumulative defined daily dose (DDD) with a nine-month lagged exposure update introduced to reduce the effect of reverse causation