C-reactive protein to albumin ratio combined with the Systemic Inflammatory Response Index predicts the prognosis of patients undergoing radical hepatectomy

Table 2 Univariate and multivariate analysis of variables affecting overall survival

Characteristics	Univariate			Multivariate
Characteristics	HR	95%CI	P	HR	95%CI	P
Age (≥ 65 years)	1.27	0.51–1.23	0.294	-	-	-
Sex (male/female)	1.05	0.66–1.38	0.788
BMI (≥ 18.5 kg/\({m}^{2}\))	1.02	0.6–1.6	0.928	-	-	-
HBV-DNA (> 100 IU/ml)	0.61	1.23–2.2	0.001	1.43	1.06–1.94	0.021
Prothrombin time (> 13 s)	0.66	1.16–1.99	0.002	1.34	1.01–1.77	0.041
AFP (> 400 ng/mL)	0.67	1.14–1.96	0.004	-	-	-
Total bilirubin (> 20 μmol/L)	1.18	0.55–1.3	0.445	-	-	-
ALT (> 40 U/L)	1.17	0.65–1.14	0.283	-	-	-
AST (> 40 U/L)	0.69	1.11–1.91	0.007	-	-	-
Child–Pugh class (A/B)	0.8	0.75–2.07	0.403	-	-	-
Ascites (Yes/No)	0.62	1.16–2.23	0.005	-	-	-
Size of tumor (cm, ≤ 3/3–5/> 5)	0.44	1.8–2.86	< 0.001	1.5	1.17–1.93	0.002
Liver cirrhosis (Yes/No)	1.2	0.62–1.12	0.224	-	-	-
Tumor number (Single/Multiple)	0.67	1.08–2.04	0.014	-	-	-
MVI (Yes/No)	0.37	2.02–3.64	< 0.001	2.18	1.61–2.94	< 0.001
Edmondson-Steiner grade(I- 11/III-IV)	0.59	1.28–2.24	< 0.001	2.09	1.54–2.83	< 0.001
Macrovascular-invasion (Yes/No)	0.28	2.65–4.67	< 0.001	1.46	1.1–1.93	0.009
CAR (> 0.105)	0.4	1.9–3.28	< 0.001	1.44	1.07–1.94	0.016
mGPS (0/1/2)	0.55	1.53–2.18	< 0.001	-	-	-
MLR (> 0.245)	0.48	1.52–2.8	< 0.001	-	-	-
NLR (> 2.45)	0.41	1.84–3.16	< 0.001	1.32	0.93–1.88	0.118
PLR (> 146.2)	0.48	1.58–2.75	< 0.001	-	-	-
PNI (< 47.5)	0.61	1.24–2.14	< 0.001	1.25	0.94–1.66	0.133
SII (> 504.5)	0.44	1.73–2.97	< 0.001	-	-	-
SIRI (> 1.075)	0.41	1.88–3.23	< 0.001	1.48	1.04–2.1	0.031

ISSN: 1471-2407