Clinical and biochemical amenorrhea in premenopausal patients with breast cancer treated with chemotherapy - a prospective cohort study

Table 2 Cox proportional hazards regression analysis for time to clinical amenorrhea

Predictor	Coefficient (log HR)	Standard Error	Hazard Ratio (HR)	P value	95% CI for HR
Age	-0.012	0.0414	0.9881	0.7725	[0.9111, 1.0716]
^z,2 Body Mass Index BMI^z,2	0.0317	0.0521	1.0322	0.5432	[0.9320, 1.1431]
Chemotherapy Regimen	-0.2568	0.2216	0.7736	0.2467	[0.5010, 1.1944]
Hormonal Treatment	-0.0787	0.2681	0.9244	0.7692	[0.5466, 1.5632]
Biochemical Amenorrhoea	-0.0808	0.3828	0.9224	0.8329	[0.4356, 1.9533]

Note: None of the predictors, notably age, BMI, chemotherapy regimen, hormonal treatment, and biochemical amenorrhea, demonstrated statistically significant associations with the risk of clinical amenorrhea (all P >.05). Hazard ratios (HR) near 1 imply minimal effect sizes, with 95% confidence intervals including 1, highlighting the lack of significance. For the chemotherapy regimen, the reference group is Regimen A (e.g., anthracycline-based regimen). For hormone treatment, the reference group is “no hormonal treatment.”

ISSN: 1471-2407