Fig. 1

Kaplan-Meier survival estimates showing the time to clinical amenorrhea in premenopausal breast cancer patients following chemotherapy. The median time to clinical amenorrhea was 8 months, which indicates that half of patients experience cessation of menstruation within this time. The chance of not attaining clinical amenorrhea decreased as time passed; most patients had clinical amenorrhea with the progression of chemotherapy cycles. The shaded area in the curve is the 95% confidence interval, which is the range of variability in survival estimates. These findings highlight that early onset clinically reported amenorrhea may serve as an initial indicator of chemotherapy-induced ovarian suppression