Table 1 Doses used in the breast cancer PAINT first-in-human investigation

Dose Level − 1

2 min per 7 mm²

Group C – if 1 DLT out of 3 or 2 DLTs out of 6 (30 min max)

Dose Level 1 (starting dose)

3 min per 7 mm²

Group C, Cohort 1 (30 min max)

Dose Level 2

4 min per 7 mm²

Group C, Cohort 2 (30 min max)

Dose Level 3

5 min per 7 mm²

Group C, Cohort 3 (30 min max)

Group A (15 min max)

Group B (15 min max)