Fig. 4

Key genes and their prognostic effects and their associations with ESCC grade and stage. (A-B) The four-gene risk model and its efficiency in predicting ESCC status. (C-F) Independent prognostic effects of the four key genes. (G-H) Expression differences of CCND1, PKP1, JUP, and ANKRD12 among different ESCC clusters and ESCC samples of different grades. (I) Expression comparisons of CCND1, PKP1, JUP, and ANKRD12 among ESCC samples of different tumor stages