The role of CDK8 gene polymorphisms in bladder cancer susceptibility and prognosis: a study in the Chinese Han population

Table 3 Distribution of SNPs in CDK8 between patients and controls and their polymorphisms with genetic susceptibility to BC

Model	Genotype	Patients	Controls	Logistic regression
Model	Genotype	n[%]	n[%]	OR(95% CI)	Global P value
rs17083838
Codominant	GG	226[83.4%]	270[70.9%]	1	< 0.001
	AG	40[14.8%]	104[27.3%]	0.50(0.33–0.76)
	AA	5[1.8%]	7[1.8%]	1.06(0.30–3.70)
Dominant	GG	226[83.4%]	270[70.9%]	1	0.002
Dominant	AG/AA	45[16.6%]	111[29.1%]	0.53(0.35–0.80)	0.002
Recessive	GG/AG	266[98.2%]	374[98.2%]	1	0.74
Recessive	AA	5[1.8%]	7[1.8%]	1.23(0.35–4.35)	0.74
Over-dominant	GG/AA	231[85.2%]	277[72.7%]	1	0.001
Over-dominant	AG	40[14.8%]	104[27.3%]	0.50(0.33–0.76)	0.001
Allele	G	492[91%]	644[85%]	1	< 0.001
Allele	A	50[9%]	118[15%]	0.61(0.42–0.88)	< 0.001
rs7992670
Codominant	GG	94[34.7%]	118[31.0%]	1	0.34
	AG	140[51.7%]	196[51.4%]	0.88(0.61–1.28)
	AA	37[13.7%]	67[17.6%]	0.68(0.41–1.14)
Dominant	GG	94[34.7%]	118[31.0%]	1	0.32
Dominant	AG/AA	177[65.3%]	263[69.0%]	0.83(0.59–1.19)	0.32
Recessive	GG/AG	234[86.3%]	314[82.4%]	1	0.18
Recessive	AA	37[13.7%]	67[17.6%]	0.74(0.46–1.16)	0.18
Over-dominant	GG/AA	131[48.3%]	185[48.6%]	1	0.97
Over-dominant	AG	140[51.7%]	196[51.4%]	1.01(0.72–1.41)	0.97
Allele	G	328[61%]	432[57.0%]	1	0.16
Allele	A	214[39%]	330[43.0%]	0.84(0.65–1.08)	0.16

All ORs and their 95% CIs are adjusted for age, sex, and smoking status; the values in boldfaced indicate significant difference (P < 0.005). OR: odds ratio; CI: confidence interval

ISSN: 1471-2407