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Table 2 Genetic characteristics of baseline and non-baseline cohorts harboring HER2 Exon20 mutation

From: Genomic and clinical characterization of HER2 exon 20 mutations in non-small cell lung cancer: insights from a multicenter study in South China

Variables

Summary Statistics

P value

Total

(n = 20)

Baseline

(n = 16)

non-Baseline

(n = 4)

Exon 20 ins

   

0.745

 p.Y772_A775dup

14 (70)

7 (43. 8)

2 (50)

1.0

 p.G778_P780dup

5 (40)

3 (18.8)

1 (25.5)

1.0

 p.771insAYVM

3 (15)

2 (12.5)

1 (25.5)

1.0

 p.G776delinsVC

3 (15)

2 (12.5)

1 (25.5)

1.0

 p.G776delinsVV

3 (15)

2 (12.5)

1 (25.5)

1.0

 p.778insGSP

2 (10)

0 (0)

1 (25.5)

0.195

 p.V777delinsVGSP

2 (10)

2 (12.5)

0 (0)

1.0

 p.773_775delinsMMMV

2 (10)

2 (12.5)

0 (0)

1.0

CNV

   

1.0

 Amplification

8 (40)

7 (43.7)

1 (25.5)

 

 Deletion

9 (45)

7 (43.7)

2 (12.5)

 
  1. Summary statistics are shown as mean (SD) or number (%). Baseline refers to patients who have not received prior systemic anti-tumor treatment before genetic sequencing, whereas non-baseline refers to those who have received such treatment before sequencing. CNV, copy number variation. A, alanine; G, glycine; M, methionine; P, proline; S, serine; V, valine; Y, tyrosine. p.771insAYVM, insertion (ins) of the amino acids AYVM at position 771; p.773_775delinsMMMV, deletion (del) of amino acids from position 773 to 775, with insertion of MMMV; p.778insGSP, insertion (ins) of GSP at position 778; p.G776delinsVC, deletion (del) of G at position 776, with insertion (ins) of VC; p.G776delinsVV, deletion (del) of G at position 776, with insertion (ins) of VV; p.G778_P780dup, duplication (dup) of amino acids from position 778 to 780; p.V777delinsVGSP, deletion (del) of V at position 777, with insertion (ins) of VGSP; p.Y772_A775dup, duplication (dup) of amino acids from Y at position 772 to A at position 775
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BMC Cancer

ISSN: 1471-2407

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