Fig. 2

Lollipop plot for HER2 mutations and their spatial distribution in NSCLC showing mutational hotspots

HER2 mutation were found to be clustered in the tyrosine kinase domain of HER2, especially the exon 20 domain; Y-axes show the number of cases harboring at least one HER2 mutation at a specific amino acid (aa) of HER2, shown along the x-axes. Green-, yellow-, and pink-filled circles indicate missense, splice and inframe indel mutation, respectively. Rec L (green): Receptor L domain; Furin-like (red): furin-like protease domain; GF R IV (blue): growth factor receptor IV domain; Tyr protein kinase (yellow): Tyrosine protein kinase domain