Fig. 1

Elevated ADORA2B expression in HNSC and multiple cancer types. Pan-cancer analysis of ADORA2B expression in normal and tumor tissues from TCGA datasets (a). Paired analysis of ADORA2B expression in tumor and adjacent normal tissues from TCGA datasets (b). Comparative analysis of ADORA2B expression across multiple cancer types (c). Boxplot and paired plot of ADORA2B expression in HNSC tumor and normal tissues from TCGA datasets (d, e). ROC curve analysis of ADORA2B expression in HNSC (f). Independent validation of ADORA2B expression in HNSC using GSE78060 (g), GSE13601 (h), and GSE30784 (i) datasets. Abbreviations: TCGA, The Cancer Genome Atlas; HNSC, head and neck squamous cell carcinoma; ROC, receiver operating characteristic. Statistical significance: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns: not significant