Fig. 5

Predictive model performance based on baseline serum proteins in the early- and late-stage colon cancer. This figure highlights the performance of the most effective predictive model distinguishing between super and poor survivors in early-stage colon cancer based on 10 baseline serum proteins (ACTA2, ADAMTS1, ADAMTS4, APOH, CCN3, DDR1, DPT, IL15, INSR, and TP53), and late-stage colon cancer based on 8 pre-diagnostic plasma proteins (CLSTN3, EDIL3, LGALS3BP, PKD1, PPP3R1, PSMD1, TNFSF8, and YY1). The models all incorporated sex and age at diagnosis as predictors. The upper panels (A and B) showed models in the early stage. The lower panel (C and D) showed models in the late stage. Left panels (A and C) present results for model performance in super and poor survivors, and right panels (B and D) display validation across patients using imputed data