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Fig. 5 | BMC Cancer

Fig. 5

From: Adeno-associated virus-clustered regularly interspaced short palindromic repeats/cas9‑mediated ovarian cancer treatment targeting PD-L1

Fig. 5

Effect of multiple doses (9 times/week) of PD-L1 AAV particles on intratumoral lymphocyte infiltration in a mouse peritoneal dissemination model. (A–C) CD4+ T, CD8+ T, and Treg cells (Foxp3) in the tumor microenvironment of mice injected with PD-L1-AAV and control AAV particles on day 74. Representative results from eight independent experiments are shown. Red arrowheads indicate positive cells. Original magnification, ×400. Bar = 50 μm. The number of CD4+ T, CD8+ T, and Treg cells (Foxp3) in peritoneally disseminated tumors. All values are presented as mean ± SE (n = 8 in each group). Statistical significance was determined using an unpaired Student’s t-test. * p < 0.05

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BMC Cancer

ISSN: 1471-2407

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