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Table 4 Univariable analyses and multivariable logistic regression analyses for the success of PTC culture in LM patients who underwent PTNB

From: Personalized drug screening of patient-derived tumor-like cell clusters based on specimens obtained from percutaneous transthoracic needle biopsy in patients with lung malignancy: a real-world study

Variables

Univariate analysis

Multivariate analysis

HR

95%CI

P-value

HR

95%CI

P-value

Gender

 Male

0.267

0.053–1.331

0.107

   

 Female

1

     

Age(y)

 ≥65

0.130

0.016–1.081

0.059

   

 <65

1

     

ECOG PS

 <2

1

     

 ≥2

0.333

0.081–1.371

0.128

   

Extrapulmonary metastases

0.333

0.081–1.371

0.128

   

Previous systemic treatments

0.231

0.044–1.209

0.083

   

Tumor diameter

 <3

1

     

 3–6

0.905

0.094–8.716

0.931

   

 ≥6

0.314

0.030–3.285

0.334

   

Diameter of biopsy instruments

 16 G

1

     

 18 G

1.240

0.356–0.432

0.736

   

Intrapulmonary tumor number

 <2

1

     

 ≥2

0.600

0.105–3.413

0.565

   

Location

 Lower or middle lobe

1

     

 Upper lobe

0.413

0.101–1.691

0.219

   

Emphysema

0.150

0.030–0.749

0.021

   

Necrotic area over half of the tumor

0.077

0.017–0.352

0.001

0.121

0.025–0.598

0.010

  1. PTC = Patient-derived tumor-like cell clusters. LM = Lung malignancy. PTNB = Percutaneous transthoracic needle biopsy. HR = Hazard ratio. CI = Confidence interval. ECOG = Eastern Cooperation Oncology Group. PS = Performance status