Table 3 Univariate and multivariate Cox proportional hazard regression model survival analysis of SII/ALB, NLR, PLR for PFS
characteristics | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
HR (95% CI) | P | HR(95% CI) | P | |
Gender(female vs. male) | 1.494(0.596–3.75) | 0.392 | ||
Age(≤ 60 vs. >60 years) | 1.747(0.65–4.7) | 0.269 | ||
Histological types(SCC vs. non-SCC) | 1.653(0.563–4.847) | 0.36 | ||
Smoking history(yes vs. no) | 0.498(0.191–1.297) | 0.153 | ||
ECOG PS (0–1 vs. 2) | 0.131(0.012-1.4) | 0.093 | ||
NRS(4–6 vs. 7–10) | 0.17(0.051–0.559) | 0.004 | 0.327(0.146–0.736) | 0.007 |
Stage(III vs. IV) | 0.051(0.004–0.691) | 0.025 | 0.061(0.021–0.183) | <0.001 |
ICIs tyes(PD-1/PD-L1 vs. others) | 4.859(0.392–60.214) | 0.218 | ||
ICIs lines of treatments(1 vs. ≥2) | 0.093(0.006–1.332) | 0.08 | ||
ICIs combinded medication(Yes or No) | 31.303(0.534-1836.401) | 0.097 | ||
opioids dose(mg/d)(<30 vs.≥30) | 0.656(0.286–1.504) | 0.319 | ||
Adverse reaction(grade1-2 vs. 3–4) | 0.786(0.255–2.425) | 0.675 | ||
PD-L1expression(Positive vs. Negative) | 1.227(0.537-2.8) | 0.628 | ||
EGFR/ALK mutation(Positive vs. Negative) | 0.771(0.343–1.735) | 0.53 | ||
Lung surgery(Yes vs. No) | 1.946(0.882–4.295) | 0.099 | ||
NLR(≤ 3.99 vs. >3.99) | 0.465(0.179–1.205) | 0.115 | ||
PLR(≤ 195.01 vs. >195.01) | 1.25(0.493–3.171) | 0.638 | ||
SII/ALB(≤ 17.79 vs. >17.79) | 0.039(0.007–0.21) | <0.001 | 0.026(0.009–0.075) | <0.001 |