Table 3 Association between CVH levels and the risk of cancer occurrence in male and female

Overall

0.95 (0.91–0.98) ^b

0.89 (0.84–0.94) ^c

0.88 (0.84–0.93) ^c

0.85 (0.81–0.9) ^c

Oral

0.7 (0.55–0.9) ^b

0.48 (0.3–0.76) ^b

0.55 (0.37–0.82) ^b

0.45 (0.27–0.74) ^b

Esophageal

0.61 (0.49–0.77) ^c

0.14 (0.07–0.3) ^c

0.58 (0.37–0.9) ^a

0.5 (0.28–0.9) ^a

EAC

0.56 (0.44–0.72) ^c

0.07 (0.02–0.21) ^c

0.47 (0.24–0.92) ^a

0.28 (0.1–0.77) ^a

ESCC

0.88 (0.48–1.6)

0.5 (0.14–1.76)

1.01 (0.48–2.11)

1.04 (0.43–2.51)

Stomach

0.71 (0.54–0.94) ^a

0.24 (0.12–0.51) ^c

0.87 (0.5–1.5)

0.69 (0.34–1.4)

Small intestine

0.89 (0.5–1.59)

0.52 (0.17–1.59)

1.16 (0.49–2.72)

1.75 (0.67–4.59)

Colorectal

0.77 (0.69–0.86) ^c

0.56 (0.46–0.69) ^c

0.89 (0.74–1.06)

0.81 (0.66-1) ^a

Anus

0.93 (0.43–2.02)

0.71 (0.18–2.76)

1.57 (0.57–4.37)

1.17 (0.37–3.72)

Liver

0.42 (0.32–0.54) ^c

0.13 (0.06–0.3) ^c

1.03 (0.55–1.94)

0.87 (0.4–1.87)

HCC

0.36 (0.26–0.5) ^c

0.07 (0.02–0.28) ^c

1.19 (0.27–5.16)

1.03 (0.18–5.86)

CAC

0.54 (0.33–0.88) ^a

0.23 (0.07–0.77) ^a

1.02 (0.49–2.14)

0.77 (0.31–1.93)

Pancreatic

0.71 (0.56–0.9) ^b

0.44 (0.27–0.71) ^c

0.57 (0.43–0.77) ^c

0.4 (0.27–0.61) ^c

Laryngeal

0.43 (0.29–0.64) ^c

0.13 (0.03–0.57) ^b

NA

NA

Lung

0.51 (0.45–0.58) ^c

0.16 (0.1–0.24) ^c

0.49 (0.42–0.56) ^c

0.24 (0.19–0.31) ^c

SCLC

0.46 (0.33–0.65) ^c

0 (0-4.68)

0.44 (0.3–0.64) ^c

0.33 (0.18–0.59) ^b

NSCLC

0.53 (0.46–0.62) ^c

0.18 (0.11–0.28) ^c

0.54 (0.45–0.64) ^c

0.24 (0.18–0.32) ^c

Melanoma skin

1.2 (1.13–1.28) ^c

1.35 (1.24–1.48) ^c

1.12 (1.03–1.23) ^a

1.33 (1.2–1.46) ^c

Mesothelioma

0.99 (0.68–1.45)

1.03 (0.55–1.95)

0.73 (0.31–1.76)

0.81 (0.27–2.42)

Soft tissue

0.73 (0.44–1.2)

1.06 (0.52–2.17)

0.86 (0.49–1.5)

0.93 (0.49–1.78)

Breast

0.89 (0.39–2.03)

0.5 (0.1–2.45)

0.91 (0.83-1)

0.8 (0.72–0.9) ^c

Uterine

NA

NA

0.62 (0.51–0.76) ^c

0.43 (0.33–0.55) ^c

Ovarian

NA

NA

1.16 (0.85–1.59)

1.06 (0.74–1.52)

Prostate

1.15 (1.08–1.24) ^c

1.11 (1-1.23)

NA

NA

Kidney

0.7 (0.57–0.85) ^c

0.47 (0.32–0.7) ^c

0.67 (0.48–0.95) ^a

0.34 (0.21–0.56) ^c

RCC

0.76 (0.6–0.95) ^a

0.52 (0.34–0.8) ^b

0.67 (0.47–0.97) ^a

0.37 (0.22–0.62) ^c

TCC

0.66 (0.3–1.46)

0.74 (0.19–2.83)

0.28 (0.1–0.82) ^a

0.1 (0.01–0.86) ^a

Bladder

0.64 (0.51–0.79) ^c

0.42 (0.27–0.66) ^c

0.8 (0.49–1.29)

0.8 (0.43–1.47)

Brain

0.85 (0.62–1.17)

0.9 (0.55–1.47)

1.15 (0.66-2)

1.37 (0.74–2.53)

Thyroid

0.78 (0.42–1.44)

0.86 (0.35–2.13)

0.99 (0.59–1.67)

0.88 (0.48–1.6)

Lymphoma

1.03 (0.84–1.26)

1.04 (0.76–1.41)

1.01 (0.76–1.35)

1.18 (0.85–1.64)

HL

0.7 (0.34–1.47)

0.71 (0.21–2.33)

0.38 (0.16–0.9) ^a

0.63 (0.23–1.72)

NHL

1.05 (0.85–1.31)

1.12 (0.81–1.54)

1.13 (0.82–1.55)

1.34 (0.93–1.92)

Multiple myeloma

1 (0.73–1.36)

0.99 (0.62–1.59)

1.02 (0.64–1.63)

0.87 (0.5–1.53)

Leukemia

0.83 (0.65–1.06)

0.8 (0.54–1.19)

1.29 (0.82–2.02)

0.98 (0.58–1.67)