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Table 2 Association between per 10-point increment CVH score and the risk of cancer in male and female

From: Life’s essential 8 and specific cancer risk and mortality in men and women: a population-based cohort analysis of 332,417 United Kingdom participants

Cancer Type

Male

Female

P for interaction

HR (95%CI)

HR (95%CI)

Overall

0.97 (0.96–0.98) c

0.96 (0.95–0.97) c

0.839

Oral

0.82 (0.76–0.88) c

0.83 (0.75–0.93) c

0.333

Esophageal

0.71 (0.66–0.77) c

0.89 (0.79–1.01)

0.001

EAC

0.69 (0.64–0.76) c

0.78 (0.64–0.95) a

0.228

ESCC

0.78 (0.65–0.94) a

1.07 (0.9–1.27)

0.004

Stomach

0.79 (0.72–0.86) c

0.93 (0.82–1.07)

0.044

Small intestine

0.86 (0.72–1.03)

1.03 (0.85–1.24)

0.284

Colorectal

0.86 (0.83–0.89) c

0.94 (0.9–0.97) b

0.002

Anus

0.95 (0.75–1.2)

1.01 (0.83–1.21)

0.458

Liver

0.64 (0.58–0.7) c

0.83 (0.72–0.95) b

< 0.001

HCC

0.57 (0.51–0.64) c

0.78 (0.57–1.05)

0.02

CAC

0.8 (0.68–0.95) a

0.85 (0.72-1) a

0.575

Pancreatic

0.84 (0.78–0.91) c

0.84 (0.77–0.91) c

0.891

Laryngeal

0.66 (0.56–0.76) c

1.09 (0.51–2.32)

0.134

Lung

0.67 (0.64–0.7) c

0.7 (0.67–0.73) c

0.185

SCLC

0.65 (0.57–0.73) c

0.65 (0.58–0.73) c

0.87

NSCLC

0.68 (0.65–0.72) c

0.72 (0.68–0.76) c

0.062

Melanoma skin

1.08 (1.06–1.1) c

1.09 (1.07–1.11) c

0.686

Mesothelioma

1.03 (0.91–1.15)

0.97 (0.77–1.22)

0.916

Soft tissue

0.99 (0.85–1.16)

0.94 (0.83–1.07)

0.815

Breast

0.91 (0.71–1.17)

0.94 (0.92–0.96) c

0.526

Uterine

NA

0.8 (0.76–0.84) c

 

Ovarian

NA

0.99 (0.93–1.06)

 

Prostate

1.05 (1.03–1.07) c

NA

 

Kidney

0.82 (0.77–0.87) c

0.79 (0.72–0.86) c

0.517

RCC

0.84 (0.78–0.9) c

0.79 (0.72–0.87) c

0.292

TCC

0.77 (0.59-1) a

0.72 (0.5–1.04)

0.936

Bladder

0.79 (0.73–0.85) c

0.91 (0.8–1.03)

0.246

Brain

0.95 (0.87–1.05)

1.04 (0.93–1.17)

0.183

Thyroid

0.93 (0.78–1.12)

0.98 (0.88–1.1)

0.529

Lymphoma

1.01 (0.95–1.07)

1.03 (0.97–1.1)

0.681

HL

0.9 (0.71–1.13)

0.91 (0.71–1.16)

0.97

NHL

1.03 (0.96–1.09)

1.07 (1-1.15) a

0.42

Multiple myeloma

0.99 (0.91–1.09)

0.96 (0.86–1.06)

0.421

Leukemia

0.96 (0.89–1.03)

0.99 (0.9–1.08)

0.524

  1. CVH, cardiovascular disease health; Models were fully adjusted with age, ethnicity, education level, annual household income, Townsend deprivation index, alcohol status, and baseline CVD status. Additionally, for female, the model was further adjusted menopausal status. a: P < 0.05, b: P < 0.01, c: P < 0.001